Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

ROCK1 feedback regulation of the upstream small GTPase RhoA

(2012) Alan T. Tang et al.   CELLULAR SIGNALLING

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

(2012) Benjamin F. Voight et al.   PLoS Genetics

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

(2011) A. Barker et al.   DIABETES

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

(2011) R. J. Strawbridge et al.   DIABETES

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

(2011) V. Lyssenko et al.   DIABETES

Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions

(2011) Mutsuko Ohnishi et al.   FASEB JOURNAL

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese

(2011) Bin Cui et al.   PLoS One

Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11 -hydroxysteroid dehydrogenase

(2011) J. Schmid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Weighted False Discovery Rate Control Procedure Reveals Alleles at FOXA2 that Influence Fasting Glucose Levels

(2010) Chao Xing et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes

(2010) Kwang-Hoon Chun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

GWAMA: software for genome-wide association meta-analysis

(2010) Reedik Mägi et al.   BMC BIOINFORMATICS

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

Association of Genetic Risk Variants With Expression of Proximal Genes Identifies Novel Susceptibility Genes for Cardiovascular Disease

(2010) Lasse Folkersen et al.   Circulation-Cardiovascular Genetics

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

(2010) E. Ingelsson et al.   DIABETES

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

(2010) Yun Li et al.   GENETIC EPIDEMIOLOGY

Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension

(2010) Ryosuke Oguro et al.   Geriatrics & Gerontology International

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Variants in FAM13A are associated with chronic obstructive pulmonary disease

(2010) Michael H Cho et al.   NATURE GENETICS

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

(2010) Iris M Heid et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing

(2010) Hansoo Park et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Genotype Imputation

(2009) Yun Li et al.   Annual Review of Genomics and Human Genetics

A multivariate regression approach to association analysis of a quantitative trait network

(2009) S. Kim et al.   BIOINFORMATICS

KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects

(2009) Yasuhiko Shimoyama et al.   CLINICA CHIMICA ACTA

A Novel Hypomorphic PDX1 Mutation Responsible for Permanent Neonatal Diabetes With Subclinical Exocrine Deficiency

(2009) M. Nicolino et al.   DIABETES

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

(2009) Soumya Raychaudhuri et al.   NATURE GENETICS

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

(2009) Dana B Hancock et al.   NATURE GENETICS

Statistical Estimation of Correlated Genome Associations to a Quantitative Trait Network

(2009) Seyoung Kim et al.   PLoS Genetics

A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels

(2009) J. Brent Richards et al.   PLoS Genetics

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

(2009) Soumya Raychaudhuri et al.   PLoS Genetics

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

CCAAT/Enhancer Binding Protein α (C/EBPα) in Adipose Tissue Regulates Genes in Lipid and Glucose Metabolism and a Genetic Variation in C/EBPα Is Associated with Serum Levels of Triglycerides

(2008) Louise E. Olofsson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians

(2008) Rubina Tabassum et al.   JOURNAL OF HUMAN GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

(2008) Kirsi H Pietiläinen et al.   PLOS MEDICINE

Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene

(2007) David M. Irwin et al.   Comparative Biochemistry and Physiology D-Genomics & Proteomics