The Importance of Dendritic Cells in Maintaining Immune Tolerance

Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases

(2016) Paulina García-González et al.   AUTOIMMUNITY REVIEWS

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

(2016) Lucie Leveque-El mouttie et al.   BLOOD

Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells

(2016) Tae Jin Yun et al.   Cell Metabolism

Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses

(2016) Katrin D Mayer-Barber et al.   Cellular & Molecular Immunology

Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes

(2016) Karan Kohli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

(2016) Laurence Ardouin et al.   IMMUNITY

Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells

(2016) Andrew Jones et al.   IMMUNITY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation

(2016) Jakob Loschko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymic Dendritic Cell Subsets Display Distinct Efficiencies and Mechanisms of Intercellular MHC Transfer

(2016) Charles J. Kroger et al.   JOURNAL OF IMMUNOLOGY

Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1

(2016) M. Jubayer Rahman et al.   JOURNAL OF IMMUNOLOGY

Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment

(2016) Chie Hotta-Iwamura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Autoimmune manifestations in aged mice arise from early-life immune dysregulation

(2016) T. I. Mahmoud et al.   Science Translational Medicine

Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity

(2016) Tomofumi Uto et al.   Nature Communications

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

(2016) Samuele Calabro et al.   Cell Reports

Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice

(2016) Alex Steimle et al.   Journal of Immunology Research

Stromal-Derived Factor-1α and Interleukin-7 Treatment Improves Homeostatic Proliferation of Naïve CD4+ T Cells after Allogeneic Stem Cell Transplantation

(2015) Simon-David Gauthier et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

DCIR2+cDC2 DCs and Zbtb32 Restore CD4+T-Cell Tolerance and Inhibit Diabetes

(2015) Jeffrey D. Price et al.   DIABETES

NOD mice are functionally deficient in the capacity of cross-presentation

(2015) Chin-Nien Lee et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulatory dendritic cells in autoimmunity: A comprehensive review

(2015) Juan Liu et al.   JOURNAL OF AUTOIMMUNITY

Donor colonic CD103+dendritic cells determine the severity of acute graft-versus-host disease

(2015) Motoko Koyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance

(2015) Zicheng Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal CD103+CD11b− dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells

(2015) A R B M Muzaki et al.   Mucosal Immunology

The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases

(2015) Jeffrey D. Price et al.   Frontiers in Immunology

Th17 cells in inflammation and autoimmunity

(2014) Ram Pyare Singh et al.   AUTOIMMUNITY REVIEWS

Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation

(2014) S. Salem et al.   BLOOD

Molecular Signatures Differentiate Immune States in Type 1 Diabetic Families

(2014) Yi-Guang Chen et al.   DIABETES

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice

(2014) Gisela M. Vaitaitis et al.   DIABETOLOGIA

Regulation of the tolerogenic function of steady-state DCs

(2014) Hans Christian Probst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes

(2014) Stephen T. Ferris et al.   IMMUNITY

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine

(2014) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells

(2014) S. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Central Nervous System Plasmacytoid Dendritic Cells Regulate the Severity of Relapsing Experimental Autoimmune Encephalomyelitis

(2014) S. L. Bailey-Bucktrout et al.   JOURNAL OF IMMUNOLOGY

Infection of Myeloid Dendritic Cells with Listeria monocytogenes Leads to the Suppression of T Cell Function by Multiple Inhibitory Mechanisms

(2014) A. Popov et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Regulate Breach of Self-Tolerance in Autoimmune Arthritis

(2014) S. L. Jongbloed et al.   JOURNAL OF IMMUNOLOGY

Type I Interferon in Human Autoimmunity

(2014) Timothy B. Niewold   Frontiers in Immunology

Metabolic Influences That Regulate Dendritic Cell Function in Tumors

(2014) Han Dong et al.   Frontiers in Immunology

Molecular programming of steady-state dendritic cells: impact on autoimmunity and tumor immune surveillance

(2013) Dylan J. Johnson et al.   Annals of the New York Academy of Sciences

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility

(2013) Adam-Nicolas Pelletier et al.   JOURNAL OF AUTOIMMUNITY

Specialized role of migratory dendritic cells in peripheral tolerance induction

(2013) Juliana Idoyaga et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+regulatory T cell development via the CD27–CD70 pathway

(2013) Jonathan M. Coquet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vivo Ablation of Plasmacytoid Dendritic Cells Inhibits Autoimmunity through Expansion of Myeloid-Derived Suppressor Cells

(2013) M. Ioannou et al.   JOURNAL OF IMMUNOLOGY

Analysis of APC Types Involved in CD4 Tolerance and Regulatory T Cell Generation Using Reaggregated Thymic Organ Cultures

(2013) L. Guerri et al.   JOURNAL OF IMMUNOLOGY

CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L

(2013) Jeffrey D. Price et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse

(2013) Javier A. Carrero et al.   PLoS One

Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity

(2013) B. M. Janelsins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells

(2012) C. Vitali et al.   BLOOD

Zbtb46expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

(2012) Ansuman T. Satpathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage

(2012) Matthew M. Meredith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10–producing suppressive CD4+T cells

(2012) Dapeng Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppressors of Cytokine Signaling Promote Fas-Induced Apoptosis through Downregulation of NF- B and Mitochondrial Bfl-1 in Leukemic T Cells

(2012) J. Oh et al.   JOURNAL OF IMMUNOLOGY

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

(2012) Leonid A Pobezinsky et al.   NATURE IMMUNOLOGY

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

DEC-205 is a cell surface receptor for CpG oligonucleotides

(2012) M. H. Lahoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells a double-edge sword in autoimmune responses

(2012) Giada Amodio et al.   Frontiers in Immunology

Cross-Presentation of Cell-Associated Antigens by Mouse Splenic Dendritic Cell Populations

(2012) Robert I. Thacker et al.   Frontiers in Immunology

Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity

(2012) Christian T. Mayer et al.   Frontiers in Immunology

Regulatory dendritic cells: there is more than just immune activation

(2012) Susanne V. Schmidt et al.   Frontiers in Immunology

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

(2011) F.-X. Hubert et al.   BLOOD

The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

(2011) Mirjam Kool et al.   IMMUNITY

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance

(2010) Ivan Zanoni et al.   AUTOIMMUNITY

Skin-draining lymph nodes contain dermis-derived CD103- dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells

(2010) M. Guilliams et al.   BLOOD

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

(2010) G. Matteoli et al.   GUT

Features of the dendritic cell lineage

(2010) Ralph M. Steinman et al.   IMMUNOLOGICAL REVIEWS

Molecular and genetic parameters defining T-cell clonal selection

(2010) Nathalie Labrecque et al.   IMMUNOLOGY AND CELL BIOLOGY

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MHC class II–restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell–mediated autoimmunity

(2010) Magali Irla et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Merocytic Dendritic Cells Break T Cell Tolerance to   Cell Antigens in Nonobese Diabetic Mouse Diabetes

(2010) J. D. Katz et al.   JOURNAL OF IMMUNOLOGY

Functional Redundancy between Thymic CD8 + and Sirp + Conventional Dendritic Cells in Presentation of Blood-Derived Lysozyme by MHC Class II Proteins

(2010) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity

(2010) Simon S Jensen et al.   Journal of Inflammation-London

Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates

(2010) G. Obermoser et al.   LUPUS

Sequential Role of Plasmacytoid Dendritic Cells and Regulatory T Cells in Oral Tolerance

(2009) Bertrand Dubois et al.   GASTROENTEROLOGY

Interferons and autoimmune disorders

(2009) Olivier Meyer   JOINT BONE SPINE

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial Contribution of Thymic Sirp + Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner

(2009) T. Baba et al.   JOURNAL OF IMMUNOLOGY

FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells

(2009) A. Schildknecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-  production

(2008) F. Meyer-Wentrup et al.   BLOOD

Dendritic cells and cytokines in human inflammatory and autoimmune diseases

(2008) P BLANCO et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY

Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome

(2008) Tal Birnberg et al.   IMMUNITY

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

(2008) Peter D. Hughes et al.   IMMUNITY

Mechanisms and Consequences of Dendritic Cell Migration

(2008) David Alvarez et al.   IMMUNITY

Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity

(2008) Jack Hutcheson et al.   IMMUNITY

HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase–dependent mechanism

(2008) Olivier Manches et al.   JOURNAL OF CLINICAL INVESTIGATION

CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease

(2008) Husein Hadeiba et al.   NATURE IMMUNOLOGY

Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells

(2008) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-  initiates type 1 diabetes in nonobese diabetic mice

(2008) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

(2008) A. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

(2008) Scott H Robbins et al.   GENOME BIOLOGY