Molecular and genetic parameters defining T-cell clonal selection

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Functions of Notch Signaling in the Immune System: Consensus and Controversies

(2010) Julie S. Yuan et al.   Annual Review of Immunology

Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis

(2010) Jennifer Thompson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD45-Csk Phosphatase-Kinase Titration Uncouples Basal and Inducible T Cell Receptor Signaling during Thymic Development

(2010) Julie Zikherman et al.   IMMUNITY

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

(2010) Weiming Ouyang et al.   IMMUNITY

Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

(2010) Takeshi Nitta et al.   IMMUNITY

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

(2010) Jeremy Juang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel TCR Transgenic Model Reveals That Negative Selection Involves an Immediate, Bim-Dependent Pathway and a Delayed, Bim-Independent Pathway

(2010) Damian Kovalovsky et al.   PLoS One

Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection

(2010) I. K. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds

(2010) M. Saini et al.   Science Signaling

Untangling the T branch of the hematopoiesis tree

(2009) Anthony W Chi et al.   CURRENT OPINION IN IMMUNOLOGY

Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens

(2009) Q. Hu et al.   JOURNAL OF IMMUNOLOGY

 -Catenin/Tcf Determines the Outcome of Thymic Selection in Response to   TCR Signaling

(2009) D. Kovalovsky et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Extracellular Signal-Related Kinase Is Not Required for Negative Selection of Developing T Cells

(2009) M. A. McGargill et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of Nur77 by the MEK-ERK-RSK Cascade Induces Mitochondrial Translocation and Apoptosis in T Cells

(2009) A. Wang et al.   JOURNAL OF IMMUNOLOGY

A Novel Gene Essential for the Development of Single Positive Thymocytes

(2009) K. Kakugawa et al.   MOLECULAR AND CELLULAR BIOLOGY

An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

(2009) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Themis, a T cell–specific protein important for late thymocyte development

(2009) Renaud Lesourne et al.   NATURE IMMUNOLOGY

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

(2009) Andy L Johnson et al.   NATURE IMMUNOLOGY

Themis imposes new law and order on positive selection

(2009) Paul M Allen   NATURE IMMUNOLOGY

Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

(2009) Guo Fu et al.   NATURE IMMUNOLOGY

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

(2009) T. Nitta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in the naive polyclonal repertoire

(2009) H. H. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

(2009) M. S. Patrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Peptide-MHC Complex Positively Selects a Diverse and Specific CD8 T Cell Repertoire

(2009) B. Wang et al.   SCIENCE

Non-redundant function of the MEK5–ERK5 pathway in thymocyte apoptosis

(2008) Sue J Sohn et al.   EMBO JOURNAL

ERK5 regulation in naïve T-cell activation and survival

(2008) Olga Ananieva et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Low Ligand Requirement for Deletion and Lack of Synapses in Positive Selection Enforce the Gauntlet of Thymic T Cell Maturation

(2008) Peter J.R. Ebert et al.   IMMUNITY

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

(2008) Jennifer Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

(2008) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multisite Phosphorylation Regulates Bim Stability and Apoptotic Activity

(2008) Anette Hübner et al.   MOLECULAR CELL

The proline-rich sequence of CD3ε controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

(2008) Michaël Mingueneau et al.   NATURE IMMUNOLOGY

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

(2008) A. Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central tolerance: what have we learned from mice?

(2008) Tom M. McCaughtry et al.   Seminars in Immunopathology