Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis

(2015) Marvin M. van Luijn et al.   BRAIN

Biomarkers for antigen immunotherapy in allergy and type 1 diabetes

(2015) Jared M. Odegard et al.   CLINICAL IMMUNOLOGY

Effects of Type 1 Diabetes-Associated IFIH1 Polymorphisms on MDA5 Function and Expression

(2015) Benjamin M. Looney et al.   Current Diabetes Reports

DCIR2+cDC2 DCs and Zbtb32 Restore CD4+T-Cell Tolerance and Inhibit Diabetes

(2015) Jeffrey D. Price et al.   DIABETES

Reduced Expression of the MDA5 GeneIFIH1Prevents Autoimmune Diabetes

(2015) Pamela J. Lincez et al.   DIABETES

CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion

(2015) Francois P. Legoux et al.   IMMUNITY

NOD mice are functionally deficient in the capacity of cross-presentation

(2015) Chin-Nien Lee et al.   IMMUNOLOGY AND CELL BIOLOGY

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

(2015) Jaeyop Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role ofPTPN22Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human

(2015) David J. Rawlings et al.   JOURNAL OF IMMUNOLOGY

Batf3 maintains autoactivation of Irf8 for commitment of a CD8α+ conventional DC clonogenic progenitor

(2015) Gary E Grajales-Reyes et al.   NATURE IMMUNOLOGY

Population dynamics of islet-infiltrating cells in autoimmune diabetes

(2015) Angela M. Magnuson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

(2015) Kenichi Izumi et al.   Nature Communications

The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases

(2015) Jeffrey D. Price et al.   Frontiers in Immunology

Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility

(2014) H. Kallionpaa et al.   DIABETES

Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells

(2014) Rhiannon Kundu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasmacytoid dendritic cells license regulatory T cells, upon iNKT-cell stimulation, to prevent autoimmune diabetes

(2014) Lucie Beaudoin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes

(2014) Stephen T. Ferris et al.   IMMUNITY

Interleukin-2-mediated inhibition of dendritic cell development correlates with decreased CD135 expression and increased monocyte/macrophage precursors

(2014) Alan D. Guerrero et al.   IMMUNOLOGY

Impact of Protective IL-2 Allelic Variants on CD4+Foxp3+ Regulatory T Cell Function In Situ and Resistance to Autoimmune Diabetes in NOD Mice

(2014) E. Sgouroudis et al.   JOURNAL OF IMMUNOLOGY

CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells

(2014) S. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Lnk/Sh2b3Controls the Production and Function of Dendritic Cells and Regulates the Induction of IFN-γ–Producing T Cells

(2014) Taizo Mori et al.   JOURNAL OF IMMUNOLOGY

1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice

(2014) G. B. Ferreira et al.   JOURNAL OF IMMUNOLOGY

An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse

(2014) Juan Liao et al.   PLoS One

CTSH regulates  -cell function and disease progression in newly diagnosed type 1 diabetes patients

(2014) T. Floyel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase

(2014) Songqing Tang et al.   Nature Communications

Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

(2013) Adam D. Barlow et al.   DIABETES

Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes

(2013) Changyun Hu et al.   DIABETES

It's Time to Bring Dendritic Cell Therapy to Type 1 Diabetes

(2013) R. J. Creusot et al.   DIABETES

Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma

(2013) Yanmei Han et al.   HEPATOLOGY

The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells

(2013) Fernando Shahijanian et al.   HUMAN MOLECULAR GENETICS

The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility

(2013) Adam-Nicolas Pelletier et al.   JOURNAL OF AUTOIMMUNITY

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function

(2013) Atsushi Nakamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: ABIN-1 Protects against Psoriasis by Restricting MyD88 Signals in Dendritic Cells

(2013) J. A. Callahan et al.   JOURNAL OF IMMUNOLOGY

Vitamin D Controls Murine and Human Plasmacytoid Dendritic Cell Function

(2013) Nina Karthaus et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L

(2013) Jeffrey D. Price et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4+CD25hi T Cells of Type 1 Diabetic and Multiple Sclerosis Patients

(2013) Karen Cerosaletti et al.   PLoS One

MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity

(2013) Sue Tsai et al.   Frontiers in Immunology

Prevention or acceleration of type 1 diabetes by viruses

(2012) Liana Ghazarian et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs  -Cell Function

(2012) S. A. Long et al.   DIABETES

RNAi screen for kinases and phosphatases that play a role in antigen presentation by dendritic cells

(2012) Catarina F. Moita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Absence of SH2B3 mutation in nonobese diabetic mice

(2012) Y.J. Li et al.   GENETICS AND MOLECULAR RESEARCH

Interleukin-21 Receptor-Mediated Signals Control Autoreactive T Cell Infiltration in Pancreatic Islets

(2012) Tom L. Van Belle et al.   IMMUNITY

Interleukin-27: Balancing Protective and Pathological Immunity

(2012) Christopher A. Hunter et al.   IMMUNITY

Reduced numbers of dendritic cells with a tolerogenic phenotype in the prediabetic pancreas of NOD mice

(2012) Jojanneke M. C. Welzen-Coppens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential effect of CD69 targeting on bystander and antigen-specific T cell proliferation

(2012) Elisenda Alari-Pahissa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

(2012) Wenxian Fu et al.   NATURE IMMUNOLOGY

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial

(2011) Joanna Mitri et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The role of interferon alpha in initiation of type I diabetes in the NOD mouse

(2011) Qing Li et al.   CLINICAL IMMUNOLOGY

IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice

(2011) Ningwen Tai et al.   CLINICAL IMMUNOLOGY

Cellular Mechanisms of Restored  -Cell Tolerance Mediated by Protective Alleles of Idd3 and Idd5

(2011) E. E. Hamilton-Williams et al.   DIABETES

Central Role for Interleukin-2 in Type 1 Diabetes

(2011) M. A. Hulme et al.   DIABETES

An Allele ofIKZF1(Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes

(2011) Austin D.-E. Swafford et al.   DIABETES

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases

(2011) S L Musone et al.   GENES AND IMMUNITY

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

(2011) Lucy J. Davison et al.   HUMAN MOLECULAR GENETICS

The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

(2011) Mirjam Kool et al.   IMMUNITY

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

(2011) Helen M. McGuire et al.   IMMUNITY

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family

(2011) Hélène Bour-Jordan et al.   IMMUNOLOGICAL REVIEWS

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice

(2011) Sue M. Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA sensor–induced type I IFN prevents diabetes caused by a β cell–tropic virus in mice

(2011) Stephen A. McCartney et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo

(2011) Melissa Swiecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytokine Gene Polymorphisms and Human Autoimmune Disease in the Era of Genome-Wide Association Studies

(2011) Koen Vandenbroeck   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

CD69 Modulates Sphingosine-1-Phosphate-Induced Migration of Skin Dendritic Cells

(2011) Amalia Lamana et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR7/9 versus TLR3/MDA5 signaling during virus infections and diabetes

(2011) Melissa Swiecki et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-27 renders DC immunosuppressive by induction of B7-H1

(2011) Svetlana Karakhanova et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dendritic cell-associated lectin 2 (DCAL2) defines a distinct CD8α− dendritic cell subset

(2011) Shinji Kasahara et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells

(2011) A. W. Lau-Kilby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cluster of coregulated genes determines TGF- -induced regulatory T-cell (Treg) dysfunction in NOD mice

(2011) A. M. D'Alise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid dendritic cells: key players in the initiation and regulation of immune responses

(2010) Roberto Lande et al.   Annals of the New York Academy of Sciences

mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS

(2010) H. R. Turnquist et al.   BLOOD

IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes

(2010) Huifen Zhu et al.   Cellular & Molecular Immunology

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

(2010) S A Long et al.   GENES AND IMMUNITY

CTLA-4 is expressed by human monocyte—derived dendritic cells and regulates their functions

(2010) Stefania Laurent et al.   HUMAN IMMUNOLOGY

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

(2010) Kai Wang et al.   HUMAN MOLECULAR GENETICS

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

Development and functional specialization of CD103+dendritic cells

(2010) Maria-Luisa del Rio et al.   IMMUNOLOGICAL REVIEWS

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cell-Directed CTLA-4 Engagement during Pancreatic   Cell Antigen Presentation Delays Type 1 Diabetes

(2010) S. Karumuthil-Melethil et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Merocytic Dendritic Cells Break T Cell Tolerance to   Cell Antigens in Nonobese Diabetic Mouse Diabetes

(2010) J. D. Katz et al.   JOURNAL OF IMMUNOLOGY

C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages

(2010) Mi-Jin Kim et al.   MOLECULES AND CELLS

The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients

(2010) Elena Y Lavrikova et al.   PEDIATRIC DIABETES

Genetically Dependent ERBB3 Expression Modulates Antigen Presenting Cell Function and Type 1 Diabetes Risk

(2010) Hongjie Wang et al.   PLoS One

Novel function for interleukin-7 in dendritic cell development

(2009) T. K. Vogt et al.   BLOOD

Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes

(2009) H Kahles et al.   GENES AND IMMUNITY

Arming Treg Cells at the Inflammatory Site

(2009) Yasmine Belkaid et al.   IMMUNITY

The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8+ Dendritic Cells

(2009) Ariel Savina et al.   IMMUNITY

IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance

(2009) Aya Shiokawa et al.   IMMUNOLOGY LETTERS

Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment

(2009) Tom L. Van Belle et al.   JOURNAL OF AUTOIMMUNITY

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells

(2009) Martin Guimond et al.   NATURE IMMUNOLOGY

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tolerogenic dendritic cells for autoimmune disease and transplantation

(2008) A W Thomson et al.   ANNALS OF THE RHEUMATIC DISEASES

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

(2008) Babacar Cisse et al.   CELL

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4+CD25+FOXP3+ Regulatory T-Cells

(2008) P. Monti et al.   DIABETES

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

(2008) J. S. Allen et al.   DIABETES

STAT4: A risk factor for type 1 diabetes?

(2008) Maria I. Zervou et al.   HUMAN IMMUNOLOGY

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

(2008) Milka Sarris et al.   IMMUNITY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells

(2008) Noriyuki Fujikado et al.   NATURE MEDICINE

A20 is an antigen presentation attenuator and its inhibition overcomes regulatory T cell–mediated suppression

(2008) Xiao-Tong Song et al.   NATURE MEDICINE

Selective delivery of   cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

(2008) A. Mukhopadhaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

(2008) C. Louvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology