CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

(2015) Tomoyoshi Yamano et al.   IMMUNITY

Aire controls gene expression in the thymic epithelium with ordered stochasticity

(2015) Matthew Meredith et al.   NATURE IMMUNOLOGY

Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells

(2015) Philip Brennecke et al.   NATURE IMMUNOLOGY

The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus

(2015) Zicheng Hu et al.   Frontiers in Immunology

Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

(2014) Stephen N. Sansom et al.   GENOME RESEARCH

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus

(2014) Justin S.A. Perry et al.   IMMUNITY

CCR4 and its ligands: from bench to bedside

(2014) O. Yoshie et al.   INTERNATIONAL IMMUNOLOGY

Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive   T Cells in the Adult Thymus

(2014) J. E. Cowan et al.   JOURNAL OF IMMUNOLOGY

An Overview of the Intrathymic Intricacies of T Cell Development

(2014) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns

(2014) J. O. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution

(2014) Sanghee Ki et al.   Cell Reports

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic control of  1 integrin adhesion by the plexinD1-sema3E axis

(2013) Y. I. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection

(2013) Ivan Lilyanov Dzhagalov et al.   PLOS BIOLOGY

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease

(2012) SuJin Hwang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

(2012) Yoshihiro Ueda et al.   Nature Communications

Chemotactic Migration of T Cells towards Dendritic Cells Promotes the Detection of Rare Antigens

(2012) Renske M. A. Vroomans et al.   PLoS Computational Biology

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

(2011) F.-X. Hubert et al.   BLOOD

Control of central and peripheral tolerance by Aire

(2011) Todd C. Metzger et al.   IMMUNOLOGICAL REVIEWS

Cytokine crosstalk for thymic medulla formation

(2010) Takeshi Nitta et al.   CURRENT OPINION IN IMMUNOLOGY

Functional Redundancy between Thymic CD8 + and Sirp + Conventional Dendritic Cells in Presentation of Blood-Derived Lysozyme by MHC Class II Proteins

(2010) D. F. Atibalentja et al.   JOURNAL OF IMMUNOLOGY

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

Differential Contribution of Chemotaxis and Substrate Restriction to Segregation of Immature and Mature Thymocytes

(2009) Lauren I. Richie Ehrlich et al.   IMMUNITY

The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

(2009) Christian Koble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crucial Contribution of Thymic Sirp + Conventional Dendritic Cells to Central Tolerance against Blood-Borne Antigens in a CCR2-Dependent Manner

(2009) T. Baba et al.   JOURNAL OF IMMUNOLOGY

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

(2009) T. Nitta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

(2008) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic cells in the thymus contribute to T-regulatory cell induction

(2008) A. I. Proietto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unbiased analysis, enrichment and purification of thymic stromal cells

(2007) Daniel H.D. Gray et al.   JOURNAL OF IMMUNOLOGICAL METHODS