Article
Oncology
Jing Zhao, Huiling Cao, Wenfan Zhang, Yongjuan Fan, Shujuan Shi, Rong Wang
Summary: SOX14 hypermethylation is significantly increased in cervical cancer tissues compared to normal tissues, showing potential as a diagnostic biomarker with high sensitivity and specificity. It has the ability to distinguish between normal, cervical intraepithelial neoplasia, and cancer samples, making it a valuable tool for early detection of cervical cancer.
Article
Multidisciplinary Sciences
Sophie Cowman, Barry Pizer, Violaine See
Summary: This study investigated the impact of chronic hypoxia on DNA repair gene expression in glioblastoma cell lines, revealing that hypoxia primarily resulted in downregulation of DNA repair genes, with the extent of downregulation depending on the severity of hypoxia. Some downregulations were directly controlled by HIF activity, indicating that multiple molecular mechanisms are involved in hypoxia-induced reprogramming of DNA repair gene transcription.
Article
Biochemistry & Molecular Biology
Weiyu Ni, Haitao Zhang, Zixuan Mei, Hongyi Zhou, Yizheng Wu, Wenbin Xu, Yan Ma, Wentao Yang, Yi Liang, Tianyuan Gu, Yingfeng Su, Shunwu Fan, Shuying Shen, Ziang Hu
Summary: This study identified a hypoxia-activated long noncoding RNA involved in cartilage homeostasis and demonstrated its function in maintaining matrix homeostasis through regulating DNA repair pathway in chondrocytes.
Review
Genetics & Heredity
Shuying Wu, He Zhu, Yishi Wu, Cong Wang, Xuefeng Duan, Tianmin Xu
Summary: Despite advancements in screening and vaccination, cervical cancer remains a significant global health burden. The standard treatment for cervical cancer includes surgery, radiation therapy, and chemotherapy. However, many advanced-stage patients have poor outcomes due to radioresistance. Recent studies have shown that long noncoding RNAs (lncRNAs) play a role in regulating cancer radiosensitivity through various mechanisms. This review aims to summarize the molecular mechanisms of lncRNAs in cervical cancer and radiosensitivity, providing potential targets for cervical cancer radiotherapy in clinical settings.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Xin Wang, Chen Cao, Xiangyu Tan, Xueyao Liao, Xiaofang Du, Xueqian Wang, Ting Liu, Danni Gong, Zheng Hu, Xun Tian
Summary: SETD8 mutation is frequently associated with cisplatin resistance in cervical cancer. Knockdown of SETD8 increases cervical cancer cell sensitivity to cisplatin by reducing 53BP1 binding to DNA breaks and inhibiting the non-homologous end joining repair pathway. Furthermore, SETD8 expression is correlated with cisplatin resistance and poor prognosis in cervical cancer patients. The small molecule inhibitor UNC0379 enhances cisplatin sensitivity in vitro and in vivo.
CELL AND BIOSCIENCE
(2023)
Review
Cell Biology
Wojciech M. Ciszewski, Katarzyna Sobierajska, Anna Stasiak, Waldemar Wagner
Summary: The presence of high levels of L-lactate in the cancer microenvironment has a characteristic feature, which can affect cancer cells through its receptoric and epigenetic modes of action and may be associated with drug resistance. Increased DNA repair capacity and enhanced drug efflux are important mechanisms for ineffective radiotherapy and drug-based therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Xinghao Wang, Chen Xu, Hongzan Sun
Summary: This study explores the effect of DNA damage repair-related genes on immune function in cervical cancer patients, and establishes a prognosis model based on these genes. The immune score and key genes related to immune cell infiltration are analyzed. The study finds that DNA damage repair-related genes can effectively predict the prognosis in cervical cancer.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Ya-Fei Hu, Hai-Jie Hu, Heng-Chung Kung, Tian-Run Lv, Jun Yu, Fu-Yu Li
Summary: The efficacy of platinum-based chemotherapy (PtCh) for pancreatic cancer (PC) patients with DNA damage repair gene mutations (DDRm) remains uncertain. This study analyzed multiple studies and found that DDRm was associated with a longer overall survival (OS) in advanced-stage PC patients, regardless of PtCh exposure. The first-line PtCh (1L-PtCh) also improved progression-free survival (PFS) in advanced-stage PC with DDRm. However, for resected PC patients, the presence of DDRm did not significantly impact OS, whether they received PtCh or not. Further prospective trials are needed to verify the prognostic value of DDRm.
FRONTIERS IN ONCOLOGY
(2023)
Article
Peripheral Vascular Disease
Xiao-Jing Chen, Wen-Fei Wei, Zi-Ci Wang, Nisha Wang, Chu-Hong Guo, Chen-Fei Zhou, Luo-Jiao Liang, Sha Wu, Li Liang, Wei Wang
Summary: A novel lymphatic pattern LVEM encapsulating lymphatic vessels by TAMs in the hypoxic TME promotes metastasis of CSCC. IL-10 derived from hypoxic TAMs induces Sp1 upregulation in LECs, facilitating LVEM formation and a positive feedback loop that strengthens LNM. Knockdown of Sp1 or blockage of CCL1 disrupts LVEM formation and attenuates LNM.
Article
Microbiology
Walason Abjaude, Bruna Prati, Veridiana Munford, Aline Montenegro, Vanesca Lino, Suellen Herbster, Tatiana Rabachini, Lara Termini, Carlos Frederico Martins Menck, Enrique Boccardo
Summary: Infection with certain types of HPV can lead to various cancers, including cervical cancer. The DNA repair machinery plays a crucial role in both HPV replication and tumor cell survival. In this study, we identified that inhibition of the ATM/CHK2/BRCA1 pathway selectively affects the proliferation of cervical cancer cells, suggesting a potential therapeutic target for cervical cancer and other HPV-associated tumors.
Article
Cell Biology
Jian-Xian Lin, Ning-Zi Lian, You-Xin Gao, Qiao-Ling Zheng, Ying-Hong Yang, Yu-Bin Ma, Zhi-Song Xiu, Qing-Zhu Qiu, Hua-Gen Wang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Jia-Bin Wang, Chang-Ming Huang
Summary: LHPP expression is significantly decreased in gastric cancer tissues and is associated with poor prognosis and chemotherapy sensitivity. The study also found that LHPP is regulated by m6A methylation and regulates the metabolism of gastric cancer by changing the acetylation level. These findings suggest that LHPP may serve as a potential predictive biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yang Yang, Yaling Li, Ruiqun Qi, Lan Zhang
Summary: This study presented a 5-gene signature prognostic system based on the hypoxic pathway of cervical cancer, which can independently evaluate the prognostic risk of patients and has been experimentally validated. These signature genes can regulate the biological functions of cervical cancer cells, providing potential targets for the treatment of cervical cancer patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
J. Pascual, G. Attard, F-C Bidard, G. Curigliano, L. De Mattos-Arruda, M. Diehn, A. Italiano, J. Lindberg, J. D. Merker, C. Montagut, N. Normanno, K. Pantel, G. Pentheroudakis, S. Popat, J. S. Reis-Filho, J. Tie, J. Seoane, N. Tarazona, T. Yoshino, N. C. Turner
Summary: Circulating tumour DNA (ctDNA) assays conducted on plasma are proving to be valuable tools for identifying actionable mutations in patients with advanced cancer and for detecting molecular residual disease or relapse in early-stage cancer. However, tissue-based testing is still preferred due to the limitations of ctDNA assays.
ANNALS OF ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zuhir Bodalal, Nino Bogveradze, Leon C. ter Beek, Jose G. van den Berg, Joyce Sanders, Ingrid Hofland, Stefano Trebeschi, Kevin B. W. Groot Lipman, Koen Storck, Eun Kyoung Hong, Natalya Lebedyeva, Monique Maas, Regina G. H. Beets-Tan, Fernando M. Gomez, Ieva Kurilova
Summary: This retrospective proof-of-principle study explores the potential of MRI-derived imaging markers in predicting tumour hypoxia non-invasively in patients with colorectal liver metastases (CLM). The results suggest that MRI-derived imaging markers can predict tumour hypoxia.
INSIGHTS INTO IMAGING
(2023)
Article
Medicine, General & Internal
Neeraj Agarwal, Arun A. Azad, Joan Carles, Andre P. Fay, Nobuaki Matsubara, Daniel Heinrich, Cezary Szczylik, Ugo De Giorgi, Jae Young Joung, Peter C. C. Fong, Eric Voog, Robert J. Jones, Neal Shore, Curtis Dunshee, Stefanie Zschaebitz, Jan Oldenburg, Xun Lin, Cynthia G. Healy, Nicola Di Santo, Fabian Zohren, Karim Fizazi
Summary: This study compared the efficacy and safety of talazoparib plus enzalutamide versus enzalutamide alone in patients with metastatic castration-resistant prostate cancer. The results showed that the combination of talazoparib and enzalutamide significantly improved radiographic progression-free survival compared to enzalutamide alone, with clinically meaningful benefits.
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)