Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action

Structure and function of carbonic anhydrases

(2016) C. T. Supuran   BIOCHEMICAL JOURNAL

Advances in structure-based drug discovery of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Discovery

Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

(2016) Francesca Margheri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors

(2016) Chandra Bhushan Mishra et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Isoform-selective inhibitory profile of 2-imidazoline-substituted benzene sulfonamides against a panel of human carbonic anhydrases

(2016) Claudiu T. Supuran et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars

(2016) Adriano Mollica et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Multicomponent chemistry in the synthesis of carbonic anhydrase inhibitors

(2016) Stanislav Kalinin et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases

(2016) Cem Yamali et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells

(2016) Cristina Federici et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

(2016) Jorge R. A. Diaz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Acridine Orange is an Effective Anti-Cancer Drug that Affects Mitochondrial Function in Osteosarcoma Cells

(2015) Caterina Fotia et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment

(2015) Francesca Perut et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors

(2015) Lorenzo Di Cesare Mannelli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Acetazolamide for the treatment of idiopathic intracranial hypertension

(2015) Claudiu T Supuran   Expert Review of Neurotherapeutics

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

(2015) Paul C. McDonald et al.   Oncotarget

Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum —The η-carbonic anhydrases

(2014) Sonia Del Prete et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent advances in the discovery of zinc-binding motifs for the development of carbonic anhydrase inhibitors

(2014) Jean-Yves Winum et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Biochemical characterization of recombinant β-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacteriumPorphyromonas gingivalis

(2014) Sonia Del Prete et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

An overview of the alpha-, beta- and gamma-carbonic anhydrases fromBacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?

(2014) Clemente Capasso et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors

(2013) Giuseppina De Simone et al.   Expert Opinion on Drug Discovery

Anti-infective carbonic anhydrase inhibitors: a patent and literature review

(2013) Clemente Capasso et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiglaucoma carbonic anhydrase inhibitors: a patent review

(2013) Emanuela Masini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Anticancer carbonic anhydrase inhibitors: a patent review (2008 – 2013)

(2013) Simona Maria Monti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antiobesity carbonic anhydrase inhibitors: a literature and patent review

(2013) Andrea Scozzafava et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)

(2013) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture

(2013) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Sulfa and trimethoprim-like drugs – antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors

(2013) Clemente Capasso et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Translational Research of Photodynamic Therapy with Acridine Orange which Targets Cancer Acidity

(2012) Katsuyuki Kusuzaki et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity

(2012) Claudiu T Supuran   EXPERT OPINION ON EMERGING DRUGS

Sulfonamides: a patent review (2008 – 2012)

(2012) Fabrizio Carta et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure-based drug discovery of carbonic anhydrase inhibitors

(2012) Claudiu T. Supuran   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

(2012) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies

(2011) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology

(2011) Francesca Fabrizi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Bacterial Carbonic Anhydrases as Drug Targets: Toward Novel Antibiotics?

(2011) Claudiu T. Supuran   Frontiers in Pharmacology

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

(2010) Fabio Pacchiano et al.   CHEMICAL COMMUNICATIONS

Photodynamic therapy with acridine orange in musculoskeletal sarcomas

(2010) T. Matsubara et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model

(2009) Ludwig Dubois et al.   RADIOTHERAPY AND ONCOLOGY

A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radiodynamic therapy with acridine orange

(2008) Tomoki Nakamura et al.   JOURNAL OF SURGICAL ONCOLOGY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY