CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

Molecular mechanism of Ena/VASP-mediated actin-filament elongation

(2011) Dennis Breitsprecher et al.   EMBO JOURNAL

mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation

(2011) Wah Ing Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing branched actin filaments in lamellipodia by electron tomography

(2011) Changsong Yang et al.   NATURE CELL BIOLOGY

Filopodia initiation

(2011) Changsong Yang et al.   Cell Adhesion & Migration

Individual Actin Filaments in a Microfluidic Flow Reveal the Mechanism of ATP Hydrolysis and Give Insight Into the Properties of Profilin

(2011) Antoine Jégou et al.   PLOS BIOLOGY

The Eps8/IRSp53/VASP Network Differentially Controls Actin Capping and Bundling in Filopodia Formation

(2011) Federico Vaggi et al.   PLoS Computational Biology

I-BAR domain proteins: linking actin and plasma membrane dynamics

(2010) Hongxia Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

VASP is a processive actin polymerase that requires monomeric actin for barbed end association

(2010) Scott D. Hansen et al.   JOURNAL OF CELL BIOLOGY

IRSp53 Links the Enterohemorrhagic E. coli Effectors Tir and EspFU for Actin Pedestal Formation

(2009) Stefanie M. Weiss et al.   Cell Host & Microbe

Filopodia: Complex models for simple rods

(2009) Jan Faix et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity

(2009) Corinna Sawallisch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY

VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis

(2009) N. F. Neel et al.   JOURNAL OF CELL SCIENCE

A novel flow cytometric assay to quantify interactions between proteins and membrane lipids

(2009) Koen Temmerman et al.   JOURNAL OF LIPID RESEARCH

F- and G-Actin Concentrations in Lamellipodia of Moving Cells

(2009) Stefan A. Koestler et al.   PLoS One

Coordination of Membrane and Actin Cytoskeleton Dynamics during Filopodia Protrusion

(2009) Changsong Yang et al.   PLoS One

The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair

(2009) T. S. Stappenbeck et al.   SCIENCE

I-BAR domains, IRSp53 and filopodium formation

(2009) Sohail Ahmed et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)

(2009) Elisabetta Menna et al.   PLOS BIOLOGY

Capping Protein Increases the Rate of Actin-Based Motility by Promoting Filament Nucleation by the Arp2/3 Complex

(2008) Orkun Akin et al.   CELL

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation

(2008) Dennis Breitsprecher et al.   EMBO JOURNAL

The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics

(2008) Kim Buay Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ena/VASP Proteins Capture Actin Filament Barbed Ends

(2008) Lejla Pasic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2

(2008) W. Abou-Kheir et al.   JOURNAL OF CELL SCIENCE

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

(2008) Giorgio Scita et al.   TRENDS IN CELL BIOLOGY

Reorganisation of the dendritic actin network during cancer cell migration and invasion

(2007) Danijela Vignjevic et al.   SEMINARS IN CANCER BIOLOGY