Systemic iron homeostasis and erythropoiesis

Characterization of Putative Erythroid Regulators of Hepcidin in Mouse Models of Anemia

(2017) Cornel S. G. Mirciov et al.   PLoS One

Hematopoietic deletion of transferrin receptor 2 in mice leads to a block in erythroid differentiation during iron-deficient anemia

(2016) Gautam Rishi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B

(2016) Céline Besson-Fournier et al.   BLOOD

Hepcidin in the diagnosis of iron disorders

(2016) D. Girelli et al.   BLOOD

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

(2016) A. Nai et al.   BLOOD

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

(2016) Susanna Canali et al.   BLOOD

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

(2016) Philipp-Sebastian Koch et al.   BLOOD

Isocitrate treatment of acute anemia of inflammation in a mouse model

(2016) Airie Kim et al.   BLOOD CELLS MOLECULES AND DISEASES

Hepcidin regulation in the anemia of inflammation

(2016) Chia-Yu Wang et al.   CURRENT OPINION IN HEMATOLOGY

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

(2016) Susanna Canali et al.   ENDOCRINOLOGY

The mutual control of iron and erythropoiesis

(2016) C. Camaschella et al.   International Journal of Laboratory Hematology

Iron and the liver

(2016) Antonello Pietrangelo   LIVER INTERNATIONAL

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

Pharmacological Targeting of the Hepcidin/Ferroportin Axis

(2016) Giada Sebastiani et al.   Frontiers in Pharmacology

Regulation of hepcidin expression by inflammation-induced activin B

(2016) Yohei Kanamori et al.   Scientific Reports

Beyond soluble transferrin receptor: Old challenges and new horizons

(2015) Kristian Harms et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Hepcidin: regulation of the master iron regulator

(2015) Gautam Rishi et al.   BIOSCIENCE REPORTS

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia

(2015) C. Guida et al.   BLOOD

TfR2 links iron metabolism and erythropoiesis

(2015) K. Pantopoulos   BLOOD

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

(2015) A. Pagani et al.   HAEMATOLOGICA

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

(2015) Chloé Latour et al.   HEPATOLOGY

Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation

(2015) Paul J. Schmidt   JOURNAL OF BIOLOGICAL CHEMISTRY

Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin

(2015) Patricia Kent et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein

(2015) Eleanor G Healey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

(2015) A. Pagani et al.   HAEMATOLOGICA

Mechanistic and regulatory aspects of intestinal iron absorption

(2014) Sukru Gulec et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6

(2014) C. Mayeur et al.   BLOOD

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype

(2014) S. Zumerle et al.   BLOOD

The second transferrin receptor regulates red blood cell production in mice

(2014) A. Nai et al.   BLOOD

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

(2014) X.-g. Wu et al.   BLOOD

Global transcriptome analyses of human and murine terminal erythroid differentiation

(2014) X. An et al.   BLOOD

Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

(2014) Yatrik M. Shah et al.   GASTROENTEROLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

The IRP/IRE system in vivo: insights from mouse models

(2014) Nicole Wilkinson et al.   Frontiers in Pharmacology

Primitive and definitive erythropoiesis in mammals

(2014) James Palis   Frontiers in Physiology

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2  mRNA translation

(2013) N. Wilkinson et al.   BLOOD

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response

(2013) Chanté L. Richardson et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

In Situ Proximity Ligation Assays Indicate That Hemochromatosis Proteins Hfe and Transferrin Receptor 2 (Tfr2) Do Not Interact

(2013) Gautam Rishi et al.   PLoS One

Multi-Copper Oxidases and Human Iron Metabolism

(2013) Ganna Vashchenko et al.   Nutrients

Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption

(2013) Bruno Galy et al.   Cell Reports

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2

(2012) Paul J. Schmidt et al.   AMERICAN JOURNAL OF HEMATOLOGY

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice

(2012) G. Casanovas et al.   HAEMATOLOGICA

Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

(2012) Zhuzhen Zhang et al.   HEPATOLOGY

N- and C-terminal Transactivation Domains of GATA1 Protein Coordinate Hematopoietic Program

(2012) Hiroshi Kaneko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis

(2012) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockout Mouse Models of Iron Homeostasis

(2011) Robert E. Fleming et al.   Annual Review of Nutrition

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

(2011) D. Meynard et al.   BLOOD

Chronic IFN-  production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

(2011) S. F. Libregts et al.   BLOOD

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

(2011) A. Pagani et al.   BLOOD

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

(2011) Matthew Taylor et al.   GASTROENTEROLOGY

Conditional disruption of mouse HFE2 gene: Maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin

(2011) Konstantinos Gkouvatsos et al.   HEPATOLOGY

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II

(2011) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis

(2010) H. Forejtnikova et al.   BLOOD

Iron control of erythroid development by a novel aconitase-associated regulatory pathway

(2010) G. C. Bullock et al.   BLOOD

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

(2010) A.-S. Zhang et al.   BLOOD

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution

(2010) G. Kovtunovych et al.   BLOOD

Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption

(2010) Liviu Vanoaica et al.   Cell Metabolism

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

(2010) Ivana De Domenico et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

(2009) T. Tanno et al.   BLOOD

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

(2009) Junwei Gao et al.   Cell Metabolism

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

(2009) D. R. Ashby et al.   HAEMATOLOGICA

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I

(2008) H. Tamary et al.   BLOOD

Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

(2008) B.-M. Zhu et al.   BLOOD

Hfe Acts in Hepatocytes to Prevent Hemochromatosis

(2008) Maja Vujić Spasić et al.   Cell Metabolism

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS