Role of MAIT cells in the immunopathogenesis of inflammatory diseases: New players in old game

IL-12 and IL-7 synergize to control mucosal-associated invariant T-cell cytotoxic responses to bacterial infection

(2018) Joshua C. Wallington et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression and trafficking of MR1

(2017) Rajesh Lamichhane et al.   IMMUNOLOGY

The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells

(2017) Jianyun Liu et al.   IMMUNOLOGY

Invariant natural killer T cells and mucosal-associated invariant T cells in multiple sclerosis

(2017) Elena Bianchini et al.   IMMUNOLOGY LETTERS

MAIT-cells: A tailor-made mate in the ancient battle against infectious diseases?

(2017) Marcela de Lima Moreira et al.   IMMUNOLOGY LETTERS

Decrease of CD69 levels on TCR Vα7.2+CD4+ innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients

(2017) Yean K Yong et al.   Innate Immunity

Deficiencies of Circulating Mucosal-associated Invariant T Cells and Natural Killer T Cells in Patients with Multiple Trauma

(2017) Young-Goun Jo et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Smoking reduces circulating CD26 hi CD161 hi MAIT cells in healthy individuals and patients with multiple sclerosis

(2017) Cecilie Ammitzbøll et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How MR1 Presents a Pathogen Metabolic Signature to Mucosal-Associated Invariant T (MAIT) Cells

(2017) Hamish E.G. McWilliam et al.   TRENDS IN IMMUNOLOGY

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells

(2017) Jeffrey Y. W. Mak et al.   Nature Communications

MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

(2017) Christopher R. Shaler et al.   PLOS BIOLOGY

Challenge of Humans with Wild-type Salmonella enterica Serovar Typhi Elicits Changes in the Activation and Homing Characteristics of Mucosal-Associated Invariant T Cells

(2017) Rosângela Salerno-Goncalves et al.   Frontiers in Immunology

Innate Lymphoid Cells: Immunoregulatory Cells of Mucosal Inflammation

(2017) V. Kumar   European Journal of Inflammation

Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells

(2017) Erica S. Lovelace et al.   PLoS One

Epigenetic silencing of V(D)J recombination is a major determinant for selective differentiation of mucosal-associated invariant t cells from induced pluripotent stem cells

(2017) Yutaka Saito et al.   PLoS One

MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications

(2017) Dominic Paquin-Proulx et al.   PLoS One

Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for NontypeableHaemophilus influenzaeInfection

(2016) Timothy S. C. Hinks et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Immunology of CD1- and MR1-Restricted T Cells

(2016) Lucia Mori et al.   Annual Review of Immunology

The frequency of mucosal-associated invariant T cells is selectively increased in dermatitis herpetiformis

(2016) Jane Li et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis

(2016) Marion Salou et al.   CLINICAL IMMUNOLOGY

Peripheral loss of CD8+CD161++TCRVα7·2+mucosal-associated invariant T cells in chronic hepatitis C virus-infected patients

(2016) Muttiah Barathan et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells

(2016) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T cells are reduced and functionally immature in the peripheral blood of primary Sjögren's syndrome patients

(2016) Jing J. Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy

(2016) Julia Hengst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MAIT, MR1, microbes and riboflavin: a paradigm for the co-evolution of invariant TCRs and restricting MHCI-like molecules?

(2016) Stanislas Mondot et al.   IMMUNOGENETICS

MHC class I-related molecule, MR1, and mucosal-associated invariant T cells

(2016) Katarzyna Franciszkiewicz et al.   IMMUNOLOGICAL REVIEWS

Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease

(2016) Timothy S. C. Hinks   IMMUNOLOGY

The role of mucosal-associated invariant T cells in infectious diseases

(2016) Emily B. Wong et al.   IMMUNOLOGY

Persistent deficiency of circulating mucosal-associated invariant T (MAIT) cells in ANCA-associated vasculitis

(2016) Cécile Braudeau et al.   JOURNAL OF AUTOIMMUNITY

MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection

(2016) Anda I. Meierovics et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis

(2016) Keiichi Haga et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

(2016) Hannah C. Jeffery et al.   JOURNAL OF HEPATOLOGY

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

(2016) Bruno Laugel et al.   JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T cells from patients with tuberculosis exhibit impaired immune response

(2016) Jing Jiang et al.   JOURNAL OF INFECTION

Functional role of mucosal-associated invariant T cells in HIV infection

(2016) Alireza Saeidi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation

(2016) A Gibbs et al.   Mucosal Immunology

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

(2016) J M Greene et al.   Mucosal Immunology

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals

(2016) Z Chen et al.   Mucosal Immunology

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets

(2016) Alka Khaitan et al.   PLoS One

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation

(2016) Liyen Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals

(2016) Pierre Boudinot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-inflammatory interventions—what has worked, not worked, and what may work in the future

(2016) Fatemeh Fattahi et al.   Translational Research

Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease

(2016) Andrew L. Durham et al.   Translational Research

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

(2016) Erin W. Meermeier et al.   Nature Communications

MAIT cells are activated during human viral infections

(2016) Bonnie van Wilgenburg et al.   Nature Communications

Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling

(2016) Jing Jiang et al.   Scientific Reports

Activation, Impaired Tumor Necrosis Factor-α Production, and Deficiency of Circulating Mucosal-Associated Invariant T Cells in Patients with Scrub Typhus

(2016) Seung-Ji Kang et al.   PLoS Neglected Tropical Diseases

The dynamics of mucosal-associated invariant T cells in multiple sclerosis

(2016) Chie Sugimoto et al.   SpringerPlus

Increased tumor infiltration by mucosal-associated invariant T cells correlates with poor survival in colorectal cancer patients

(2015) Luciane Zabijak et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Early innate responses to pathogens: pattern recognition by unconventional human T-cells

(2015) Anna Rita Liuzzi et al.   CURRENT OPINION IN IMMUNOLOGY

MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response toMycobacterium tuberculosis

(2015) Marielle C. Gold et al.   IMMUNOLOGICAL REVIEWS

Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease

(2015) Eitaro Hiejima et al.   INFLAMMATORY BOWEL DISEASES

Mucosal-associated invariant T cell–rich congenic mouse strain allows functional evaluation

(2015) Yue Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

(2015) Isabelle Magalhaes et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

(2015) Azad Rahimpour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-γ

(2015) Patrik Sundström et al.   JOURNAL OF IMMUNOLOGY

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites

(2015) Isaac G. Sakala et al.   JOURNAL OF IMMUNOLOGY

Deficiencies of Circulating Mucosal-associated Invariant T Cells and Natural Killer T Cells in Patients with Acute Cholecystitis

(2015) Jung-Chul Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection

(2015) James E. Ussher et al.   MEDICINE

CD161intCD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut

(2015) J R Fergusson et al.   Mucosal Immunology

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Innate immunity in diabetes and diabetic nephropathy

(2015) Jun Wada et al.   Nature Reviews Nephrology

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection

(2015) Edwin Leeansyah et al.   PLoS Pathogens

Mucosal-Associated Invariant T Cells in Inflammatory Bowel Diseases: Bystanders, Defenders, or Offenders?

(2015) Emmanuel Treiner   Frontiers in Immunology

CD1d- and MR1-Restricted T Cells in Sepsis

(2015) Peter A. Szabo et al.   Frontiers in Immunology

Role of Innate T Cells in Anti-Bacterial Immunity

(2015) Yifang Gao et al.   Frontiers in Immunology

MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases

(2015) Lauren J. Howson et al.   Frontiers in Immunology

Mucosal-Associated Invariant T Cell Is a Potential Marker to Distinguish Fibromyalgia Syndrome from Arthritis

(2015) Chie Sugimoto et al.   PLoS One

CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on lsong-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

(2014) Louise Greathead et al.   AIDS

Expression of MAIT Cells in Blood and Genital Mucosa of HIV Infected and Uninfected Women

(2014) Anna Gibbs et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

MAIT cells and pathogen defense

(2014) Siobhán C. Cowley   CELLULAR AND MOLECULAR LIFE SCIENCES

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

(2014) N.-E. Serriari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Advances in the understanding and treatment of systemic complications in Sjögrenʼs syndrome

(2014) Pilar Brito-Zerón et al.   CURRENT OPINION IN RHEUMATOLOGY

CD8+MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis

(2014) Anne Willing et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MAIT cells are depleted early but retain functional cytokine expression in HIV infection

(2014) Caroline S Fernandez et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of CCR2 in Inflammatory Conditions of the Central Nervous System

(2014) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Innate Immunity in Sepsis Pathogenesis and Its Modulation: New Immunomodulatory Targets Revealed

(2014) V. Kumar et al.   JOURNAL OF CHEMOTHERAPY

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

(2014) Marielle C. Gold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

(2014) Sidonia B.G. Eckle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microbe-Specific Unconventional T Cells Induce Human Neutrophil Differentiation into Antigen Cross-Presenting Cells

(2014) Martin S. Davey et al.   JOURNAL OF IMMUNOLOGY

Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus

(2014) Young-Nan Cho et al.   JOURNAL OF IMMUNOLOGY

The IL-17A-Producing CD8 + T-Cell Population in Psoriatic Lesional Skin Comprises Mucosa-Associated Invariant T Cells and Conventional T Cells

(2014) Marcel B.M. Teunissen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

(2014) A Kurioka et al.   Mucosal Immunology

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-Infection

(2014) Emily B. Wong et al.   PLoS One

Reduced Mucosal Associated Invariant T-Cells Are Associated with Increased Disease Severity and Pseudomonas aeruginosa Infection in Cystic Fibrosis

(2014) Daniel J. Smith et al.   PLoS One

Frequent involvement of central nervous system in primary Sjögren syndrome

(2014) Isabel Moreira et al.   RHEUMATOLOGY INTERNATIONAL

The Decrease in Number and Change in Phenotype of Mucosal-Associated Invariant T cells in the Elderly and Differences in Men and Women of Reproductive Age

(2014) J. Novak et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

(2014) Marco Lepore et al.   Nature Communications

Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver

(2014) Juandy Jo et al.   PLoS Pathogens

Mucosal-Associated Invariant T-Cells: New Players in Anti-Bacterial Immunity

(2014) James E. Ussher et al.   Frontiers in Immunology

MAIT cells, surveyors of a new class of antigen: development and functions

(2013) Lionel Le Bourhis et al.   CURRENT OPINION IN IMMUNOLOGY

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Circulating mucosal-associated invariant T cell levels and their cytokine levels in healthy adults

(2013) O-Jin Lee et al.   EXPERIMENTAL GERONTOLOGY

Innate lymphoid cells: New paradigm in immunology of inflammation

(2013) Vijay Kumar   IMMUNOLOGY LETTERS

Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections

(2013) David Grimaldi et al.   INTENSIVE CARE MEDICINE

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Double Positive Thymocytes Select Mucosal-Associated Invariant T Cells

(2013) N. Seach et al.   JOURNAL OF IMMUNOLOGY

IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells

(2013) X.-Z. Tang et al.   JOURNAL OF IMMUNOLOGY

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

(2013) Lionel Le Bourhis et al.   PLoS Pathogens

IL-17 cytokines in immunity and inflammation

(2013) Wei Jin et al.   Emerging Microbes & Infections

CD3+CD8+CD161high Tc17 cells are depleted in HIV-infection

(2012) Julie Christine Gaardbo et al.   AIDS

2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

(2012) J. C. Jennette et al.   ARTHRITIS AND RHEUMATISM

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection

(2012) E. Leeansyah et al.   BLOOD

Early and nonreversible decrease of CD161++/MAIT cells in HIV infection

(2012) C. Cosgrove et al.   BLOOD

Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection

(2012) Stephen J. Polyak et al.   HEPATOLOGY

Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals

(2012) Kentaro Tsukamoto et al.   IMMUNOGENETICS

Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection

(2012) Wei-Jen Chua et al.   INFECTION AND IMMUNITY

Analysis of stem-cell-like properties of human CD161++IL-18R + memory CD8+ T cells

(2012) S. H. C. Havenith et al.   INTERNATIONAL IMMUNOLOGY

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress

(2012) M C Gold et al.   Mucosal Immunology

Co-dependents: MR1-restricted MAIT cells and their antimicrobial function

(2012) Marielle C. Gold et al.   NATURE REVIEWS MICROBIOLOGY

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silibinin Inhibits HIV-1 Infection by Reducing Cellular Activation and Proliferation

(2012) Janela McClure et al.   PLoS One

Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis

(2011) Asako Chiba et al.   ARTHRITIS AND RHEUMATISM

Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161hi CD8 + semi-invariant T cells

(2011) C. J. Turtle et al.   BLOOD

Human MAIT and CD8   cells develop from a pool of type-17 precommitted CD8+ T cells

(2011) L. J. Walker et al.   BLOOD

CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis

(2011) Viviana Annibali et al.   BRAIN

Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis

(2011) Yusei Miyazaki et al.   INTERNATIONAL IMMUNOLOGY

Mucosal associated invariant T cells and the immune response to infection

(2011) Marielle C. Gold et al.   MICROBES AND INFECTION

Mucosal-associated invariant T cells: unconventional development and function

(2011) Lionel Le Bourhis et al.   TRENDS IN IMMUNOLOGY

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Neutrophils: Cinderella of innate immune system

(2010) V. Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mast cells: Emerging sentinel innate immune cells with diverse role in immunity

(2010) V. Kumar et al.   MOLECULAR IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

(2009) Cameron J. Turtle et al.   IMMUNITY

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

Invariant V 7.2-J 33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells

(2008) A. Peterfalvi et al.   INTERNATIONAL IMMUNOLOGY

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE