Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1

(2016) Timothy S.C. Hinks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response toMycobacterium tuberculosis

(2015) Marielle C. Gold et al.   IMMUNOLOGICAL REVIEWS

Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease

(2015) Timothy Stopford Christopher Hinks   INFLAMMATORY BOWEL DISEASES

Reduced Numbers and Proapoptotic Features of Mucosal-associated Invariant T Cells as a Characteristic Finding in Patients with Inflammatory Bowel Disease

(2015) Eitaro Hiejima et al.   INFLAMMATORY BOWEL DISEASES

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

(2015) Timothy S.C. Hinks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mucosal-associated invariant T cell–rich congenic mouse strain allows functional evaluation

(2015) Yue Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

(2015) Isabelle Magalhaes et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

(2015) Azad Rahimpour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity

(2015) Eirin Carolan et al.   JOURNAL OF IMMUNOLOGY

Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data

(2015) Timothy Hinks et al.   LANCET

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

(2014) N.-E. Serriari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

MAIT cells are depleted early but retain functional cytokine expression in HIV infection

(2014) Caroline S Fernandez et al.   IMMUNOLOGY AND CELL BIOLOGY

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus

(2014) Young-Nan Cho et al.   JOURNAL OF IMMUNOLOGY

Systemic lupus erythematosus

(2014) Larissa Lisnevskaia et al.   LANCET

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

MAITs, MR1 and vitamin B metabolites

(2013) Richard W Birkinshaw et al.   CURRENT OPINION IN IMMUNOLOGY

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission

(2013) Mirjana Rajilić-Stojanović et al.   INFLAMMATORY BOWEL DISEASES

Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection

(2013) D O'Shea et al.   INTERNATIONAL JOURNAL OF OBESITY

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Double Positive Thymocytes Select Mucosal-Associated Invariant T Cells

(2013) N. Seach et al.   JOURNAL OF IMMUNOLOGY

IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells

(2013) X.-Z. Tang et al.   JOURNAL OF IMMUNOLOGY

Immunopathogenic mechanisms of systemic autoimmune disease

(2013) Marie Wahren-Herlenius et al.   LANCET

Persistent Changes in Circulating and Intestinal γδ T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease

(2013) Margaret R. Dunne et al.   PLoS One

MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

(2013) A. Meierovics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

(2013) Onisha Patel et al.   Nature Communications

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

(2013) Lionel Le Bourhis et al.   PLoS Pathogens

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection

(2012) E. Leeansyah et al.   BLOOD

Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP

(2012) S. Gerart et al.   BLOOD

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination

(2012) Hui Yee Greenaway et al.   IMMUNOBIOLOGY

Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals

(2012) Kentaro Tsukamoto et al.   IMMUNOGENETICS

Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection

(2012) Wei-Jen Chua et al.   INFECTION AND IMMUNITY

Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn’s disease

(2012) Akira Andoh et al.   JOURNAL OF GASTROENTEROLOGY

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress

(2012) M C Gold et al.   Mucosal Immunology

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

(2011) Tina Herbst et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis

(2011) Asako Chiba et al.   ARTHRITIS AND RHEUMATISM

Human MAIT and CD8   cells develop from a pool of type-17 precommitted CD8+ T cells

(2011) L. J. Walker et al.   BLOOD

Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis

(2011) Yusei Miyazaki et al.   INTERNATIONAL IMMUNOLOGY

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion

(2011) Anna Lluis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)

(2010) J. P. Schmid et al.   BLOOD

The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis

(2010) Jiehua Chen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

(2010) Philippe Georgel et al.   MOLECULAR IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk of invasive pneumococcal infections among working age adults with asthma

(2010) P. Klemets et al.   THORAX

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results

(2009) C. Crim et al.   EUROPEAN RESPIRATORY JOURNAL

The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus

(2009) B. C.-H. Kwan et al.   RHEUMATOLOGY

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

(2008) Chun Kwok Wong et al.   CLINICAL IMMUNOLOGY

Invariant V 7.2-J 33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells

(2008) A. Peterfalvi et al.   INTERNATIONAL IMMUNOLOGY

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of IL-13 and NK T cells in experimental and human ulcerative colitis

(2008) I J Fuss et al.   Mucosal Immunology

Virus Infection, Asthma, and Chronic Obstructive Pulmonary Disease

(2008) Ratko Djukanović et al.   NEW ENGLAND JOURNAL OF MEDICINE