MAIT cells and pathogen defense

CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on lsong-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

(2014) Louise Greathead et al.   AIDS

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

(2014) Marielle C. Gold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Low Levels of Peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) Cells Are Found in HIV and HIV/TB Co-Infection

(2014) Emily B. Wong et al.   PLoS One

Will loss of your mucosa-associated invariant T cells weaken your HAART?

(2013) Johan K. Sandberg et al.   AIDS

Commensal microbiota and NKT cells in the control of inflammatory diseases at mucosal surfaces

(2013) Sebastian Zeissig et al.   CURRENT OPINION IN IMMUNOLOGY

MAIT cells, surveyors of a new class of antigen: development and functions

(2013) Lionel Le Bourhis et al.   CURRENT OPINION IN IMMUNOLOGY

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections

(2013) David Grimaldi et al.   INTENSIVE CARE MEDICINE

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

(2013) A. Meierovics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

(2013) Lionel Le Bourhis et al.   PLoS Pathogens

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection

(2012) E. Leeansyah et al.   BLOOD

Early and nonreversible decrease of CD161++/MAIT cells in HIV infection

(2012) C. Cosgrove et al.   BLOOD

Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals

(2012) Kentaro Tsukamoto et al.   IMMUNOGENETICS

Turned on by danger: activation of CD1d-restricted invariant natural killer T cells

(2012) Victoria Lawson   IMMUNOLOGY

Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection

(2012) Wei-Jen Chua et al.   INFECTION AND IMMUNITY

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress

(2012) M C Gold et al.   Mucosal Immunology

Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis

(2011) Asako Chiba et al.   ARTHRITIS AND RHEUMATISM

Human MAIT and CD8   cells develop from a pool of type-17 precommitted CD8+ T cells

(2011) L. J. Walker et al.   BLOOD

CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis

(2011) Viviana Annibali et al.   BRAIN

Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection

(2011) Manfred Brigl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

iNKT Cell Frequency in Peripheral Blood of Caucasian Children and Adolescent: The Absolute iNKT Cell Count is Stable from Birth to Adulthood

(2011) K. Bienemann et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Evaluation of the immunoregulatory activity of intraepithelial lymphocytes in a mouse model of chronic intestinal inflammation

(2010) D. V. Ostanin et al.   INTERNATIONAL IMMUNOLOGY

The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice

(2010) Philippe Georgel et al.   MOLECULAR IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens

(2009) Manfred Brigl et al.   SEMINARS IN IMMUNOLOGY

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE