TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

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Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver

(2014) Juandy Jo et al.   PLoS Pathogens

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

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Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

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IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells

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Lipoteichoic acid of Enterococcus faecalis induces the expression of chemokines via TLR2 and PAFR signaling pathways

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Early and nonreversible decrease of CD161++/MAIT cells in HIV infection

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ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes

(2012) Chunyan Zhang et al.   Cellular & Molecular Immunology

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

(2012) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161hi CD8 + semi-invariant T cells

(2011) C. J. Turtle et al.   BLOOD

Human MAIT and CD8   cells develop from a pool of type-17 precommitted CD8+ T cells

(2011) L. J. Walker et al.   BLOOD

Endogenous MHC-Related Protein 1 Is Transiently Expressed on the Plasma Membrane in a Conformation That Activates Mucosal-Associated Invariant T Cells

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HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control

(2011) H. N. Kloverpris et al.   JOURNAL OF VIROLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

Endotoxin tolerance: new mechanisms, molecules and clinical significance

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Flagellin is the principal inducer of the antimicrobial peptide S100A7c (psoriasin) in human epidermal keratinocytes exposed to Escherichia coli

(2008) Arby Abtin et al.   FASEB JOURNAL

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells

(2008) Shouxiong Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE