Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers

Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ

(2017) M Escoll et al.   ONCOGENE

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

(2017) A Noto et al.   ONCOGENE

The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy

(2016) Marco Napoli et al.   BRITISH JOURNAL OF CANCER

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

MCM7and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer

(2016) Federica Lo Sardo et al.   CARCINOGENESIS

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

(2016) Toshiro Moroishi et al.   CELL

The Hippo pathway, p53 and cholesterol

(2016) Yael Aylon et al.   CELL CYCLE

YAP/TAZ as therapeutic targets in cancer

(2016) Francesca Zanconato et al.   CURRENT OPINION IN PHARMACOLOGY

Shikonin regulates C-MYC and GLUT1 expression through the MST1-YAP1-TEAD1 axis

(2016) Karel Vališ et al.   EXPERIMENTAL CELL RESEARCH

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

(2016) Yael Aylon et al.   GENES & DEVELOPMENT

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Targeting mutant p53 through the mevalonate pathway

(2016) William Freed-Pastor et al.   NATURE CELL BIOLOGY

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

(2016) Andrew G. Cox et al.   NATURE CELL BIOLOGY

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

(2016) Alejandro Parrales et al.   NATURE CELL BIOLOGY

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

(2016) Giulia Santinon et al.   TRENDS IN CELL BIOLOGY

The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair

(2016) Emma Fallahi et al.   Genes

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis

(2016) Xuetian Yue et al.   Cell Discovery

Oncogenic Intra-p53 Family Member Interactions in Human Cancers

(2016) Maria Ferraiuolo et al.   Frontiers in Oncology

Structure and apoptotic function of p73

(2015) Mi-Kyung Yoon et al.   BMB Reports

PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53

(2015) Mona Sobhani et al.   CANCER BIOLOGY & THERAPY

Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis

(2015) Chantal Bou-Hanna et al.   CANCER LETTERS

Abstract 4444: Small molecule drug Verteporfin inhibits TAZ/YAP-driven signaling and tumorigenicity of breast cancer cells

(2015) Han Sun et al.   CANCER RESEARCH

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53

(2015) Shengliang Zhang et al.   CANCER RESEARCH

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulateVEGFR2in breast cancer cells

(2015) Neil T. Pfister et al.   GENES & DEVELOPMENT

P63 in health and cancer

(2015) Stefania Gonfloni et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities

(2015) Madhusudhan Kollareddy et al.   Nature Communications

Wnt activated β-catenin and YAP proteins enhance the expression of non-coding RNA component of RNase MRP in colon cancer cells

(2015) Jinjoo Park et al.   Oncotarget

Analysis of p53 Transactivation Domain Mutants Reveals Acad11 as a Metabolic Target Important for p53 Pro-Survival Function

(2015) Dadi Jiang et al.   Cell Reports

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

(2015) Minchul Kim et al.   Cell Reports

BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

(2015) Xuetian Yue et al.   eLife

Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

(2015) Yusuke Oku et al.   FEBS Open Bio

Mutant p53: One, No One, and One Hundred Thousand

(2015) Dawid Walerych et al.   Frontiers in Oncology

Targeting Oncogenic Mutant p53 for Cancer Therapy

(2015) Alejandro Parrales et al.   Frontiers in Oncology

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

(2015) Fabio Valenti et al.   Oncotarget

Chemopreventive Effects of the p53-Modulating Agents CP-31398 and Prima-1 in Tobacco Carcinogen-Induced Lung Tumorigenesis in A/J Mice

(2015) Chinthalapally V. Rao et al.   NEOPLASIA

Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents

(2014) M N Saha et al.   BRITISH JOURNAL OF CANCER

Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells

(2014) Amjad Ali et al.   CANCER LETTERS

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

Lats2 is critical for the pluripotency and proper differentiation of stem cells

(2014) Y Aylon et al.   CELL DEATH AND DIFFERENTIATION

Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells

(2014) Wenjun Yu et al.   CELLULAR SIGNALLING

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

Mutant p53 reactivation by small molecules makes its way to the clinic

(2014) Vladimir J.N. Bykov et al.   FEBS LETTERS

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

(2014) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients

(2013) F. Ganci et al.   ANNALS OF ONCOLOGY

Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53

(2013) Nan Bai et al.   CANCER BIOLOGY & THERAPY

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

YAP/TEAD-Mediated Transcription Controls Cellular Senescence

(2013) Q. Xie et al.   CANCER RESEARCH

ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence

(2013) F Fausti et al.   CELL DEATH AND DIFFERENTIATION

Prima-1 induces apoptosis in bladder cancer cell lines by activating p53

(2013) CB Piantino et al.   Clinics

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

(2013) Steven G. Chaulk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma By Induction of p73 and Noxa

(2013) Manujendra N. Saha et al.   MOLECULAR CANCER THERAPEUTICS

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells

(2013) S Masciarelli et al.   ONCOGENE

Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET

(2013) R. Shalom-Feuerstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Hippo pathway and implications for anticancer drug development

(2013) Hyun Woo Park et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells

(2013) Amjad Ali et al.   Nature Communications

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

(2013) Qian Wu et al.   Cell Reports

PML Surfs into HIPPO Tumor Suppressor Pathway

(2013) Sabrina Strano et al.   Frontiers in Oncology

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop

(2012) Fabio Valenti et al.   CELL CYCLE

TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin

(2012) Nuo Yang et al.   CELL CYCLE

Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model

(2012) Fábio T. Watanabe et al.   Clinics

The p53 family grows old

(2012) E. R. Flores et al.   GENES & DEVELOPMENT

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

A new role of p53 in regulating lipid metabolism

(2012) Xingwu Wang et al.   Journal of Molecular Cell Biology

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

(2011) S Donzelli et al.   CELL DEATH AND DIFFERENTIATION

PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53

(2011) R. Zandi et al.   CLINICAL CANCER RESEARCH

Hippo signaling inDrosophila: Recent advances and insights

(2011) Binnaz Kucuk Staley et al.   DEVELOPMENTAL DYNAMICS

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation

(2011) Chad Deisenroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53

(2010) Perry Stambolsky et al.   CANCER CELL

The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs

(2010) Silvia Di Agostino et al.   CELL CYCLE

Improving pharmacological rescue of p53 function: RITA targets mutant p53

(2010) Javier E. Girardini et al.   CELL CYCLE

The retinal dehydrogenase/reductaseretSDR1/DHRS3gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes

(2010) Ralf D. Kirschner et al.   CELL CYCLE

Id2gene is a transcriptional target of the protein complex mutant p53/E2F1

(2010) Giulia Fontemaggi et al.   CELL CYCLE

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

(2010) P. Karpowicz et al.   DEVELOPMENT

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

(2010) Y. Aylon et al.   GENES & DEVELOPMENT

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP

(2010) A. M. Vigneron et al.   GENES & DEVELOPMENT

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

(2009) Maria A. Lebedeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms

(2009) Brittney Jung-Hynes et al.   FASEB JOURNAL

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

(2009) Giulia Fontemaggi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Deregulating EMT and Senescence: Double Impact by a Single Twist

(2008) Marjon A. Smit et al.   CANCER CELL

The Hippo–YAP pathway: new connections between regulation of organ size and cancer

(2008) Bin Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

YAP and p73: A Complex Affair

(2008) Julian Downward et al.   MOLECULAR CELL

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL

Twist and p53 reciprocally regulate target genes via direct interaction

(2008) M Shiota et al.   ONCOGENE

The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like

(2008) L. A. Baena-Lopez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA