PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53

PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance

(2014) B. Tessoulin et al.   BLOOD

Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma

(2013) D N T Aryee et al.   BRITISH JOURNAL OF CANCER

The Bone Marrow Microenvironment in Waldenström Macroglobulinemia

(2013) Amit Agarwal et al.   Clinical Lymphoma Myeloma & Leukemia

PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma By Induction of p73 and Noxa

(2013) Manujendra N. Saha et al.   MOLECULAR CANCER THERAPEUTICS

Waldenström Macroglobulinemia: 2012 update on diagnosis, risk stratification, and management

(2012) Morie A. Gertz   AMERICAN JOURNAL OF HEMATOLOGY

Molecular pathogenesis of Waldenstrom's macroglobulinemia

(2012) E. Braggio et al.   HAEMATOLOGICA

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Waldenström macroglobulinemia: my way

(2012) Morie Gertz   LEUKEMIA & LYMPHOMA

Waldenström Macroglobulinemia

(2011) Saad P. Shaheen et al.   ADVANCES IN ANATOMIC PATHOLOGY

Establishment and characterization of a novel Waldenstrom macroglobulinemia cell line, MWCL-1

(2011) L. S. Hodge et al.   BLOOD

PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo

(2011) Wenjie Bao et al.   CELL CYCLE

PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53

(2011) R. Zandi et al.   CLINICAL CANCER RESEARCH

Reactivation of p53 mutants by p53 reactivation and induction of massive apoptosis in thyroid cancer cells

(2011) Rosa Linda Messina et al.   INTERNATIONAL JOURNAL OF CANCER

APR-246 exhibits anti-leukemic activity and synergism with conventional chemotherapeutic drugs in acute myeloid leukemia cells

(2010) Dina Ali et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines

(2010) Stephen M. Ansell et al.   MAYO CLINIC PROCEEDINGS

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis

(2009) J M R Lambert et al.   ONCOGENE

Mutated and non-mutated TP53 as targets in the treatment of leukaemia

(2008) H. Nahi et al.   BRITISH JOURNAL OF HAEMATOLOGY

PRIMA-1met radiosensitizes prostate cancer cells independent of their MTp53-status

(2008) Stéphane Supiot et al.   RADIOTHERAPY AND ONCOLOGY