Polycomb Repressor Complex 2 in Genomic Instability and Cancer

Effect and Mechanism of Curcumin on EZH2 - miR-101 Regulatory Feedback Loop in Multiple Myeloma

(2018) Chuanqing Wu et al.   CURRENT PHARMACEUTICAL DESIGN

Emerging genotype–phenotype relationships in patients with large NF1 deletions

(2017) Hildegard Kehrer-Sawatzki et al.   HUMAN GENETICS

Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome

(2017) Eri Imagawa et al.   HUMAN MUTATION

Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis

(2017) Dan Sarni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

(2017) Claire L. Donohoe et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

(2017) Haikuo Zhang et al.   Nature Communications

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

(2016) Wendy Béguelin et al.   CANCER CELL

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

The novel EZH2 inhibitor, GSK126, suppresses cell migration and angiogenesis via down-regulating VEGF-A

(2016) Ya-Tian Chen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

(2016) Ana S.A. Cohen et al.   HUMAN MUTATION

Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival

(2016) Arjen H G Cleven et al.   MODERN PATHOLOGY

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis

(2016) Sang Ah Yi et al.   MOLECULAR CELL

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

(2016) Xi Jiang et al.   Nature Communications

Developing EZH2-Targeted Therapy for Lung Cancer

(2016) A. E. Frankel et al.   Cancer Discovery

EZH2 promotes cell migration and invasion but not alters cell proliferation by suppressing E-cadherin, partly through association with MALAT-1 in pancreatic cancer

(2016) Ting Han et al.   Oncotarget

Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1

(2016) Guo-Qing Wu et al.   Oncotarget

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

(2016) Nikos Papakonstantinou et al.   Oncotarget

Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma

(2015) Ling Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells

(2015) Tsang-Pai Liu et al.   ANTI-CANCER DRUGS

Activation of EZH2 and SUZ12 Regulated by E2F1 Predicts the Disease Progression and Aggressive Characteristics of Bladder Cancer

(2015) S.-R. Lee et al.   CLINICAL CANCER RESEARCH

Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis

(2015) Michel Wassef et al.   GENES & DEVELOPMENT

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

(2015) Wei Wang et al.   MEDICINAL RESEARCH REVIEWS

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors

(2015) V Gibaja et al.   ONCOGENE

SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin

(2015) Rui Xia et al.   TUMOR BIOLOGY

Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma

(2015) MINFEI JIN et al.   Oncology Letters

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

(2015) Daniel Zingg et al.   Nature Communications

Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer

(2015) Huiming Chen et al.   Oncotarget

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

(2015) Jessamy C. Tiffen et al.   Oncotarget

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height

(2015) Katrina Tatton-Brown et al.   Oncotarget

Dietary protein restriction inhibits tumor growth in human xenograft models

(2015) Luigi Fontana et al.   Oncotarget

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer

(2015) Zhongwu li et al.   Oncotarget

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

(2015) Shou-Hung Tang et al.   Oncotarget

Sugarcoating Polycomb Repression

(2014) C. Peter Verrijzer   DEVELOPMENTAL CELL

O-GlcNAcylation Prevents Aggregation of the Polycomb Group Repressor Polyhomeotic

(2014) Maria Cristina Gambetta et al.   DEVELOPMENTAL CELL

Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer

(2014) Yan-Long Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Overexpression of enhancer of zeste human homolog 2 (EZH2) gene in human cytomegalovirus positive glioblastoma multiforme tissues

(2014) Narges Ahani et al.   MEDICAL ONCOLOGY

Quantitative Nuclear Proteomics Identifies that miR-137-mediated EZH2 Reduction Regulates Resveratrol-induced Apoptosis of Neuroblastoma Cells

(2014) Xiaoqing Ren et al.   MOLECULAR & CELLULAR PROTEOMICS

Long Noncoding RNA ANRIL Promotes Non-Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

(2014) F.-q. Nie et al.   MOLECULAR CANCER THERAPEUTICS

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

(2014) Thomas De Raedt et al.   NATURE

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

(2014) William Lee et al.   NATURE GENETICS

miR-101, downregulated in retinoblastoma, functions as a tumor suppressor in human retinoblastoma cells by targeting EZH2

(2014) QIONG LEI et al.   ONCOLOGY REPORTS

Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents

(2014) Prakash Tiwari et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SUZ12 is involved in progression of non-small cell lung cancer by promoting cell proliferation and metastasis

(2014) Chunhua Liu et al.   TUMOR BIOLOGY

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

(2014) Andrea Piunti et al.   Nature Communications

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

(2014) Goro Sashida et al.   Nature Communications

O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins

(2014) Vanessa Dehennaut et al.   Frontiers in Endocrinology

The myelodysplastic syndrome as a prototypical epigenetic disease

(2013) J.-P. J. Issa   BLOOD

Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101

(2013) Yongjun Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Polycomb repressive complex 2 contributes to DNA double-strand break repair

(2013) Stuart Campbell et al.   CELL CYCLE

SUZ12 Depletion Suppresses the Proliferation of Gastric Cancer Cells

(2013) Yingjun Cui et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

(2013) Tomoya Muto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9

(2013) Min Jiang et al.   MOLECULES

Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer

(2013) Woojin Kim et al.   Nature Chemical Biology

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A687V EZH2 is a gain-of-function mutation found in lymphoma patients

(2012) Christina R. Majer et al.   FEBS LETTERS

EZH2 couples pancreatic regeneration to neoplastic progression

(2012) J. Mallen-St. Clair et al.   GENES & DEVELOPMENT

Polycomb (PcG) Proteins, BMI1 and SUZ12, Regulate Arsenic-induced Cell Transformation

(2012) Hong-Gyum Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)

(2012) Yi-Che Changchien et al.   Journal of Translational Medicine

SUZ12 Promotes Human Epithelial Ovarian Cancer by Suppressing Apoptosis via Silencing HRK

(2012) H. Li et al.   MOLECULAR CANCER RESEARCH

Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells

(2012) A. Avan et al.   MOLECULAR CANCER THERAPEUTICS

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

linking metabolism to epigenetics through O-GlcNAcylation

(2012) John A. Hanover et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PRC2/EED-EZH2 Complex Is Up-Regulated in Breast Cancer Lymph Node Metastasis Compared to Primary Tumor and Correlates with Tumor Proliferation In Situ

(2012) Hongxiang Yu et al.   PLoS One

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

(2012) M. T. McCabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

(2012) W. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in EZH2 Cause Weaver Syndrome

(2011) William T. Gibson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Malignant Rhabdoid Tumors Express Stem Cell Factors, Which Relate To the Expression of EZH2 and Id Proteins

(2011) Sriram Venneti et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

New mutations and pathogenesis of myeloproliferative neoplasms

(2011) W. Vainchenker et al.   BLOOD

Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications

(2011) Roberta Ciarapica et al.   BMC Medicine

Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer

(2011) Huqun et al.   CANCER

Histone Methyltransferase EZH2 Induces Akt-Dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer

(2011) M. E. Gonzalez et al.   CANCER RESEARCH

(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells

(2011) S. R. Choudhury et al.   CARCINOGENESIS

Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage

(2011) Z Wu et al.   CELL DEATH AND DIFFERENTIATION

Double-strand break-induced transcriptional silencing is associated with loss of tri-methylation at H3K4

(2011) Doris M. Seiler et al.   CHROMOSOME RESEARCH

Cooperation between Polycomb and androgen receptor during oncogenic transformation

(2011) J. C. Zhao et al.   GENOME RESEARCH

EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies

(2011) M.-Y. Cai et al.   GUT

Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy

(2011) D. Sasaki et al.   HAEMATOLOGICA

Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma

(2011) Cheng Wang et al.   MOLECULAR CARCINOGENESIS

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

Deregulated Expression of the Polycomb-Group Protein SUZ12 Target Genes Characterizes Mantle Cell Lymphoma

(2010) Daniel Martín-Pérez et al.   AMERICAN JOURNAL OF PATHOLOGY

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

(2010) Jindan Yu et al.   CANCER CELL

The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer

(2010) Liudmila L. Kodach et al.   CARCINOGENESIS

EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-β1 and is a predictor of outcome in ovarian carcinoma patients

(2010) Zhi-Yue Rao et al.   CARCINOGENESIS

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

(2010) Martin Sauvageau et al.   Cell Stem Cell

Androgens Suppress EZH2 Expression Via Retinoblastoma (RB) and p130-Dependent Pathways: A Potential Mechanism of Androgen-Refractory Progression of Prostate Cancer

(2010) Laura R. Bohrer et al.   ENDOCRINOLOGY

Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells

(2010) Wen-Feng Hua et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma

(2010) Adam D. Toll et al.   HUMAN PATHOLOGY

MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β

(2010) Paul Cao et al.   Molecular Cancer

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

(2010) Gorica Nikoloski et al.   NATURE GENETICS

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

ETS Transcription Factors Control Transcription of EZH2 and Epigenetic Silencing of the Tumor Suppressor Gene Nkx3.1 in Prostate Cancer

(2010) Paolo Kunderfranco et al.   PLoS One

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

(2010) C. J. Sneeringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

(2010) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

(2010) Valter D. Longo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis

(2010) Cheng-Gang Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis

(2009) Ø Fluge et al.   BRITISH JOURNAL OF CANCER

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells

(2009) M. Hussain et al.   CANCER RESEARCH

The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival

(2009) S. Balasubramanian et al.   CARCINOGENESIS

Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells

(2009) Manjari Dimri et al.   CARCINOGENESIS

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Activation of the Enhancer of Zeste Homologue 2 Gene by the Human Papillomavirus E7 Oncoprotein

(2008) D. Holland et al.   CANCER RESEARCH

Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells

(2008) Satoshi Fujii et al.   CANCER SCIENCE

Weaver Syndrome and Neuroblastoma

(2008) Don Coulter et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma

(2008) Motoko Sasaki et al.   LABORATORY INVESTIGATION

Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo

(2008) K. Sarma et al.   MOLECULAR AND CELLULAR BIOLOGY

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

(2008) Zehui Hong et al.   NUCLEIC ACIDS RESEARCH

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

(2008) Q Cao et al.   ONCOGENE

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

(2008) Heather M. O'Hagan et al.   PLoS Genetics