linking metabolism to epigenetics through O-GlcNAcylation

Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans

(2016) Mohammad M. Rahman et al.   Aging-US

Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation

(2012) Jessica E Rexach et al.   Nature Chemical Biology

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis

(2012) Mary Katherine Tarrant et al.   Nature Chemical Biology

Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response

(2011) In-Hyun Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Versatile Sugar Transferase Makes the Cut

(2011) John A. Hanover   CELL

O-GlcNAc Transferase Catalyzes Site-Specific Proteolysis of HCF-1

(2011) Francesca Capotosti et al.   CELL

O-Linked-N-Acetylglucosamine Cycling and Insulin Signaling Are Required for the Glucose Stress Response inCaenorhabditis elegans

(2011) Michelle A. Mondoux et al.   GENETICS

Evolutionary diversity and developmental regulation of X-chromosome inactivation

(2011) Martin Escamilla-Del-Arenal et al.   HUMAN GENETICS

Modification of Histones by Sugar β-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated

(2011) Suisheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome

(2011) C. N. Keembiyehetty et al.   JOURNAL OF CELL SCIENCE

Chemical Arsenal for the Study of O-GlcNAc

(2011) Eun J. Kim   MOLECULES

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

(2011) Michael B. Lazarus et al.   NATURE

Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway

(2011) S. Daou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells

(2011) S. A. Myers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

(2011) B. D. Muegge et al.   SCIENCE

Elevated O-GlcNAc-dependent signaling through inducible mOGT expression selectively triggers apoptosis

(2010) Sang-Hoon Shin et al.   AMINO ACIDS

Glucose-induced expression of MIP-1 genes requires O-GlcNAc transferase in monocytes

(2010) Toshihiro Chikanishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human OGA binds substrates in a conserved peptide recognition groove

(2010) Marianne Schimpl et al.   BIOCHEMICAL JOURNAL

The Exon Junction Complex Controls the Splicing of mapk and Other Long Intron-Containing Transcripts in Drosophila

(2010) Dariel Ashton-Beaucage et al.   CELL

Hooking Up with Oct4

(2010) Ihor R. Lemischka   Cell Stem Cell

An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells

(2010) Debbie L.C. van den Berg et al.   Cell Stem Cell

An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease

(2010) Mercedes Pardo et al.   Cell Stem Cell

The significance, development and progress of high-throughput combinatorial histone code analysis

(2010) Nicolas L. Young et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetics Gets Sweeter: O-GlcNAc Joins the “Histone Code”

(2010) John A. Hanover   CHEMISTRY & BIOLOGY

Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes

(2010) Tracey Gloster et al.   Current Signal Transduction Therapy

Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells

(2010) M. Dejosez et al.   GENES & DEVELOPMENT

BlockingO-Linked GlcNAc Cycling inDrosophilaInsulin-producing Cells Perturbs Glucose-Insulin Homeostasis

(2010) Osamu Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAc Transferase Regulates Mitotic Chromatin Dynamics

(2010) Kaoru Sakabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity

(2010) D. C. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -N-acetylglucosamine (O-GlcNAc) is part of the histone code

(2010) K. Sakabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAc cycling: Emerging roles in development and epigenetics

(2010) Dona C. Love et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of nucleotide sugar transporters in development of eukaryotes

(2010) Li Liu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Control of α-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities

(2009) Thomas M. Kristie et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

O-GlcNAc protein modification in plants: Evolution and function

(2009) Neil E. Olszewski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress

(2009) Chutikarn Butkinaree et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine

(2009) John A. Hanover et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ExcessiveO-GlcNAcylation of proteins suppresses spontaneous cardiogenesis in ES cells

(2009) Hoe-Suk Kim et al.   FEBS LETTERS

O-GlcNAc cycling: Implications for neurodegenerative disorders

(2009) Brooke D. Lazarus et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis

(2009) Ryoji Fujiki et al.   NATURE

The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

(2009) Mary E. Donohoe et al.   NATURE

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

(2009) Keisuke Nimura et al.   NATURE

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)

(2009) D. A. R. Sinclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of protein O-GlcNAcylation sites using electron transfer dissociation mass spectrometry on native peptides

(2009) R. J. Chalkley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role of the Glycosyltransferase Sxc/Ogt in Polycomb Repression

(2009) Maria Cristina Gambetta et al.   SCIENCE

Ronin Is Essential for Embryogenesis and the Pluripotency of Mouse Embryonic Stem Cells

(2008) Marion Dejosez et al.   CELL

Intron Delays and Transcriptional Timing during Development

(2008) Ian A. Swinburne et al.   DEVELOPMENTAL CELL

O-Linked β-N-Acetylglucosaminyltransferase Substrate Specificity Is Regulated by Myosin Phosphatase Targeting and Other Interacting Proteins

(2008) Win D. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAc Regulates FoxO Activation in Response to Glucose

(2008) Michael P. Housley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

Hepatic Glucose Sensing via the CREB Coactivator CRTC2

(2008) R. Dentin et al.   SCIENCE