The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

(2014) Yoav D. Shaul et al.   CELL

Neural crest stem cells in melanoma development

(2014) Olga Shakhova   CURRENT OPINION IN ONCOLOGY

Ezh2 is required for neural crest-derived cartilage and bone formation

(2014) D. Schwarz et al.   DEVELOPMENT

EZH2 expands breast stem cells through activation of NOTCH1 signaling

(2014) M. E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling

(2014) B. Sanchez-Laorden et al.   Science Signaling

Directed Phenotype Switching as an Effective Antimelanoma Strategy

(2013) Magalí Sáez-Ayala et al.   CANCER CELL

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming

(2013) Neha Tiwari et al.   CANCER CELL

MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2

(2013) Chonglin Luo et al.   CANCER LETTERS

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis

(2013) Marieta Caganova et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Tumor adaptation and resistance to RAF inhibitors

(2013) Piro Lito et al.   NATURE MEDICINE

Why is melanoma so metastatic?

(2013) Russell R. Braeuer et al.   Pigment Cell & Melanoma Research

A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors

(2013) Melissa L. Harris et al.   PLoS Genetics

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

(2012) S. Tanaka et al.   BLOOD

Testing the cancer stem cell hypothesis in melanoma: The clinics will tell

(2012) Olga Shakhova et al.   CANCER LETTERS

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Neural crest delamination and migration: From epithelium-to-mesenchyme transition to collective cell migration

(2012) Eric Theveneau et al.   DEVELOPMENTAL BIOLOGY

Neural crest progenitors and stem cells: From early development to adulthood

(2012) Elisabeth Dupin et al.   DEVELOPMENTAL BIOLOGY

Epigenetic alterations in hematopoietic malignancies

(2012) Young Rock Chung et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

miR-137 Inhibits the Invasion of Melanoma Cells through Downregulation of Multiple Oncogenic Target Genes

(2012) Chonglin Luo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

(2012) Olga Shakhova et al.   NATURE CELL BIOLOGY

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

(2012) M. T. McCabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of human polycomb repressive complex 2

(2012) Claudio Ciferri et al.   eLife

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

(2011) Piul Rabbani et al.   CELL

EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression

(2011) T. Fan et al.   MOLECULAR CANCER RESEARCH

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

(2010) Martin Sauvageau et al.   Cell Stem Cell

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status

(2010) Marie C. Zipser et al.   Pigment Cell & Melanoma Research

Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia

(2009) Xin Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional significance of eIF5A and its hypusine modification in eukaryotes

(2009) M. H. Park et al.   AMINO ACIDS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Stage-Specific Control of Neural Crest Stem Cell Proliferation by the Small Rho GTPases Cdc42 and Rac1

(2009) Sebastian Fuchs et al.   Cell Stem Cell

Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition

(2009) Yusuke Hirabayashi et al.   NEURON

WDR19 Expression is Increased in Prostate Cancer Compared with Normal Cells, but Low-Intensity Expression in Cancers is Associated with Shorter Time to Biochemical Failures and Local Recurrence

(2008) B. Lin et al.   CLINICAL CANCER RESEARCH

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE