A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Published 2012 View Full Article
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Title
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Authors
Keywords
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Journal
FEBS LETTERS
Volume 586, Issue 19, Pages 3448-3451
Publisher
Wiley
Online
2012-07-29
DOI
10.1016/j.febslet.2012.07.066
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Note: Only part of the references are listed.- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
- (2012) M. T. McCabe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
- (2012) J. G. Lohr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
- (2011) Tim J. Wigle et al. FEBS LETTERS
- EZH2 Y641 mutations in follicular lymphoma
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- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
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- Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
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- EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
- (2010) I. Velichutina et al. BLOOD
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation
- (2010) Paul A. Del Rizzo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
- (2010) Gillian L. Dalgliesh et al. NATURE
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
- (2010) C. J. Sneeringer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling
- (2008) J. I. Martin-Subero et al. BLOOD
- Roles of the EZH2 histone methyltransferase in cancer epigenetics
- (2008) Jeffrey A. Simon et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Repression of E-cadherin by the polycomb group protein EZH2 in cancer
- (2008) Q Cao et al. ONCOGENE
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