The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis

18F-FDG PET reveals unique features of large vessel inflammation in patients with Takayasu’s arteritis

(2017) Elena Incerti et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Pentraxin 3 deletion aggravates allergic inflammation through a T H 17-dominant phenotype and enhanced CD4 T-cell survival

(2017) Jyoti Balhara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera

(2017) Federico Lussana et al.   Journal of Hematology & Oncology

Anti-pentraxin 3 auto-antibodies might be protective in lupus nephritis: a large cohort study

(2017) Mo Yuan et al.   RENAL FAILURE

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage

(2017) Andrea Doni et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

FDG Uptake by Prosthetic Arterial Grafts in Large Vessel Vasculitis Is Not Specific for Active Disease

(2017) Taryn Youngstein et al.   JACC-Cardiovascular Imaging

Editorial: Regulation of Inflammation, Its Resolution and Therapeutic Targeting

(2017) Mariagrazia Uguccioni et al.   Frontiers in Immunology

Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation

(2016) F. Bonacina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cell death, clearance and immunity in the skeletal muscle

(2016) C Sciorati et al.   CELL DEATH AND DIFFERENTIATION

PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition

(2016) Cecilia Garlanda et al.   CURRENT OPINION IN IMMUNOLOGY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Complement in removal of the dead - balancing inflammation

(2016) Myriam Martin et al.   IMMUNOLOGICAL REVIEWS

Pentraxins in the activation and regulation of innate immunity

(2016) Kenji Daigo et al.   IMMUNOLOGICAL REVIEWS

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

(2016) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunization with pentraxin 3 (PTX3) leads to anti-PTX3 antibody production and delayed lupus-like nephritis in NZB/NZW F1 mice

(2016) Mariele Gatto et al.   JOURNAL OF AUTOIMMUNITY

The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling

(2016) Barbara Bottazzi et al.   JOURNAL OF HEPATOLOGY

Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling

(2016) Claudia Cappuzzello et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Atypical chemokine receptors in cancer: friends or foes?

(2016) Matteo Massara et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo

(2016) Jai-Nien Tung et al.   JOURNAL OF NEURO-ONCOLOGY

Clearance of Cell Remnants and Regeneration of Injured Muscle Depend on Soluble Pattern Recognition Receptor PTX3

(2016) Michela Vezzoli et al.   MOLECULAR MEDICINE

Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

(2016) Claudia Z. Han et al.   NATURE

The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

(2016) Elena Magrini et al.   TRENDS IN MOLECULAR MEDICINE

The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs

(2016) Kenji Daigo et al.   Frontiers in Immunology

Regulatory Role of IL-1R8 in Immunity and Disease

(2016) Martina Molgora et al.   Frontiers in Immunology

Detection of Anti-Pentraxin-3 Autoantibodies in ANCA-Associated Vasculitis

(2016) Amélie Simon et al.   PLoS One

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy

(2015) Roberto Ronca et al.   CANCER CELL

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

(2015) Eduardo Bonavita et al.   CELL

Macrophage polarization in pathology

(2015) Antonio Sica et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Elevations of inflammatory markers PTX3 and sST2 after resuscitation from cardiac arrest are associated with multiple organ dysfunction syndrome and early death

(2015) Giuseppe Ristagno et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

PTX3Polymorphisms and Invasive Mold Infections After Solid Organ Transplant: Figure 1.

(2015) Agnieszka Wójtowicz et al.   CLINICAL INFECTIOUS DISEASES

PTX3, Anti-PTX3, and Anti-C1q Autoantibodies in Lupus Glomerulonephritis

(2015) Nicola Bassi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3

(2015) Anna Paeschke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Apoptotic cell recognition receptors and scavenger receptors

(2015) Kristen K. Penberthy et al.   IMMUNOLOGICAL REVIEWS

Elevated Expression of Pentraxin 3 in Anti-neutrophil Cytoplasmic Antibody-associated Glomerulonephritis with Normal Serum C-reactive Protein

(2015) Risa Ishida et al.   INTERNAL MEDICINE

Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients

(2015) Maurizio Infante et al.   INTERNATIONAL JOURNAL OF CANCER

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode

(2015) Andrea Doni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Fractalkine-Receptor Axis Improves Human Colorectal Cancer Prognosis by Limiting Tumor Metastatic Dissemination

(2015) Marco Erreni et al.   JOURNAL OF IMMUNOLOGY

Transcriptomic correlates of organ failure extent in sepsis

(2015) Raquel Almansa et al.   JOURNAL OF INFECTION

Genetic variation in PTX3 and plasma levels associated with hepatocellular carcinoma in patients with HCV

(2015) R. F. Carmo et al.   JOURNAL OF VIRAL HEPATITIS

Plasma Pentraxin 3 Differentiates Nonalcoholic Steatohepatitis (NASH) from Non-NASH

(2015) Salih Boga et al.   Metabolic Syndrome and Related Disorders

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

(2015) F Guo et al.   ONCOGENE

PTX3 gene activation in EGF-induced head and neck cancer cell metastasis

(2015) Wei-Chiao Chang et al.   Oncotarget

PTX3 acts as an extrinsic oncosuppressor

(2015) Eduardo Bonavita et al.   Oncotarget

Optimizing outcome in SLE: treating-to-target and definition of treatment goals

(2014) Andrea Doria et al.   AUTOIMMUNITY REVIEWS

Abnormal blood biomarkers in early pregnancy are associated with preeclampsia: a meta-analysis

(2014) Rebecca E. Allen et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection

(2014) Sébastien Jaillon et al.   IMMUNITY

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

(2014) L. Deban et al.   JOURNAL OF IMMUNOLOGY

Serum amyloid P: a systemic regulator of the innate immune response

(2014) Nehemiah Cox et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation

(2014) Cristina Cunha et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory Biomarkers in Atherosclerosis: Pentraxin 3 Can Become a Novel Marker of Plaque Vulnerability

(2014) Akihiro Shindo et al.   PLoS One

Persistent Lung Inflammation and Fibrosis in Serum Amyloid P Component (Apcs-/-) Knockout Mice

(2014) Darrell Pilling et al.   PLoS One

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

(2014) K. Daigo et al.   Science Signaling

Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis

(2014) Enrico Tombetti et al.   ARTHRITIS RESEARCH & THERAPY

Incremental Prognostic Significance of the Elevated Levels of Pentraxin 3 in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction

(2014) Junichi Matsubara et al.   Journal of the American Heart Association

Phenotypic Transitions of Macrophages Orchestrate Tissue Repair

(2013) Margaret L. Novak et al.   AMERICAN JOURNAL OF PATHOLOGY

Myeloproliferative neoplasms and thrombosis

(2013) T. Barbui et al.   BLOOD

Clinical impact of pentraxin family expression on prognosis of pancreatic carcinoma

(2013) S Kondo et al.   BRITISH JOURNAL OF CANCER

Intravascular immunity as a key to systemic vasculitis: a work in progress, gaining momentum

(2013) G. A. Ramirez et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Macrophages: Supportive cells for tissue repair and regeneration

(2013) Bénédicte Chazaud   IMMUNOBIOLOGY

The Acute-Phase Protein PTX3 is an Essential Mediator of Glial Scar Formation and Resolution of Brain Edema after Ischemic Injury

(2013) Beatriz Rodriguez-Grande et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Biology of Human Pentraxin 3 (PTX3) in Acute and Chronic Kidney Disease

(2013) Marijn M. Speeckaert et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Ficolin-1-PTX3 Complex Formation Promotes Clearance of Altered Self-Cells and Modulates IL-8 Production

(2013) Y. J. Ma et al.   JOURNAL OF IMMUNOLOGY

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

(2013) Marco Locatelli et al.   JOURNAL OF NEUROIMMUNOLOGY

Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer

(2013) Roberto Ronca et al.   JOURNAL OF PATHOLOGY

Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury

(2013) Maciej Lech et al.   KIDNEY INTERNATIONAL

Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome

(2013) Simone Bastrup-Birk et al.   PLoS One

Long Pentraxin 3/Tumor Necrosis Factor-Stimulated Gene-6 Interaction

(2012) Daria Leali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pentraxins and Fc receptors

(2012) Jinghua Lu et al.   IMMUNOLOGICAL REVIEWS

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Atypical Hemolytic Uremic Syndrome-Associated Variants and Autoantibodies Impair Binding of Factor H and Factor H-Related Protein 1 to Pentraxin 3

(2012) A. Kopp et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies

(2012) Michael Knoflach et al.   PLoS One

Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps

(2012) Kenji Daigo et al.   Frontiers in Immunology

Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: Relevance for recent optic nerve ischemia

(2011) Mattia Baldini et al.   ARTHRITIS AND RHEUMATISM

Pentraxin 3: A novel and independent prognostic marker in ischemic stroke

(2011) Wi-Sun Ryu et al.   ATHEROSCLEROSIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Immune inhibitory receptors: Essential regulators of phagocyte function

(2011) Tessa A. M. Steevels et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pathogen Recognition by the Long Pentraxin PTX3

(2011) Federica Moalli et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early and Transient Release of Leukocyte Pentraxin 3 during Acute Myocardial Infarction

(2011) N. Maugeri et al.   JOURNAL OF IMMUNOLOGY

The chemokine system and cancer

(2011) Frances R Balkwill   JOURNAL OF PATHOLOGY

Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis

(2011) Alexander S. Savchenko et al.   PATHOLOGY INTERNATIONAL

Lack of the Long Pentraxin PTX3 Promotes Autoimmune Lung Disease but not Glomerulonephritis in Murine Systemic Lupus Erythematosus

(2011) Maciej Lech et al.   PLoS One

Human Pentraxin 3 Binds to the Complement Regulator C4b-Binding Protein

(2011) Anne Braunschweig et al.   PLoS One

The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling

(2011) A. Inforzato et al.   TISSUE ANTIGENS

Aberrant methylation of the 3q25 tumor suppressor genePTX3in human esophageal squamous cell carcinoma

(2011) Jun-Xiong Wang   WORLD JOURNAL OF GASTROENTEROLOGY

IgG anti-pentraxin 3 antibodies in systemic lupus erythematosus

(2010) N. Bassi et al.   ANNALS OF THE RHEUMATIC DISEASES

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

(2010) O. Klimchenko et al.   BLOOD

Role of complement and Fc  receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus

(2010) F. Moalli et al.   BLOOD

Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

(2010) G. Germano et al.   CANCER RESEARCH

PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients

(2010) M Chiarini et al.   GENES AND IMMUNITY

Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3

(2010) T. Barbui et al.   HAEMATOLOGICA

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

(2010) Ying Jie Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

(2010) Kodi S. Ravichandran   JOURNAL OF EXPERIMENTAL MEDICINE

Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancer

(2010) Federica Marchesi et al.   JOURNAL OF NEUROIMMUNOLOGY

Regulation of leukocyte recruitment by the long pentraxin PTX3

(2010) Livija Deban et al.   NATURE IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Takayasu arteritis—advances in diagnosis and management

(2010) Justin C. Mason   Nature Reviews Rheumatology

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

First trimester PTX3 levels in women who subsequently develop preeclampsia and fetal growth restriction

(2009) Irene Cetin et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis

(2009) Francesco Carlucci et al.   ARTHRITIS AND RHEUMATISM

Molecular mechanisms of late apoptotic/necrotic cell clearance

(2009) I K H Poon et al.   CELL DEATH AND DIFFERENTIATION

Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis

(2009) Giuseppe Danilo Norata et al.   CIRCULATION

Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations

(2009) Kazumi Yamasaki et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The chemokine system in cancer biology and therapy

(2009) Alberto Mantovani et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Chemokines and chemokine receptors: an overview

(2009) Raffaella Bonecchi   Frontiers in Bioscience-Landmark

Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations

(2009) Azubuike I. Okemefuna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Serum Amyloid P Inhibits Fibrosis Through Fc R-Dependent Monocyte-Macrophage Regulation in Vivo

(2009) A. P. Castano et al.   Science Translational Medicine

Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH)

(2008) Masato Yoneda et al.   BMC GASTROENTEROLOGY

Endogenous PTX3 translocates at the membrane of late apoptotic human neutrophils and is involved in their engulfment by macrophages

(2008) S Jaillon et al.   CELL DEATH AND DIFFERENTIATION

Cardioprotective Function of the Long Pentraxin PTX3 in Acute Myocardial Infarction

(2008) Monica Salio et al.   CIRCULATION

Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome

(2008) R. W. Tothill et al.   CLINICAL CANCER RESEARCH

Pentraxins, humoral innate immunity and tissue injury

(2008) Angelo A Manfredi et al.   CURRENT OPINION IN IMMUNOLOGY

Pattern recognition receptors in the immune response against dying cells

(2008) Pascale Jeannin et al.   CURRENT OPINION IN IMMUNOLOGY

Cell Death: Tipping the Balance of Autoimmunity and Tissue Repair

(2008) Angelo Manfredi et al.   CURRENT PHARMACEUTICAL DESIGN

Structural Characterization of PTX3 Disulfide Bond Network and Its Multimeric Status in Cumulus Matrix Organization

(2008) Antonio Inforzato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance inMycobacterium tuberculosisinfection

(2008) Diana Di Liberto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure

(2007) Satoshi Suzuki et al.   AMERICAN HEART JOURNAL

Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE−/− mice

(2007) Glenys A. Tennent et al.   ATHEROSCLEROSIS