Apoptotic cell recognition receptors and scavenger receptors

Emerging roles for scavenger receptor SREC-I in immunity

(2015) Ayesha Murshid et al.   CYTOKINE

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1

(2015) Aaron M. Fond et al.   JOURNAL OF CLINICAL INVESTIGATION

Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells

(2015) N. Ruiz-Lafuente et al.   Biology Open

Apoptotic Cells Induce NF-κB and Inflammasome Negative Signaling

(2015) Amir Grau et al.   PLoS One

Scavenger Receptor SREC-I Mediated Entry of TLR4 into Lipid Microdomains and Triggered Inflammatory Cytokine Release in RAW 264.7 Cells upon LPS Activation

(2015) Ayesha Murshid et al.   PLoS One

Myeloid Cell–Specific ATP-Binding Cassette Transporter A1 Deletion Has Minimal Impact on Atherogenesis in Atherogenic Diet–Fed Low-Density Lipoprotein Receptor Knockout Mice

(2014) Xin Bi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Standardizing Scavenger Receptor Nomenclature

(2014) M. PrabhuDas et al.   JOURNAL OF IMMUNOLOGY

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

(2014) N. Ipseiz et al.   JOURNAL OF IMMUNOLOGY

Essential Role of Elmo1 in Dock2-Dependent Lymphocyte Migration

(2014) C. Stevenson et al.   JOURNAL OF IMMUNOLOGY

Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion

(2014) Afnan Abu-Thuraia et al.   MOLECULAR AND CELLULAR BIOLOGY

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

(2014) Ronald S. Flannagan et al.   MOLECULAR BIOLOGY OF THE CELL

Diversification of TAM receptor tyrosine kinase function

(2014) Anna Zagórska et al.   NATURE IMMUNOLOGY

The Scavenger Receptor MARCO Modulates TLR-Induced Responses in Dendritic Cells

(2014) Haydn T. Kissick et al.   PLoS One

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates

(2014) N. Hamoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia

(2014) Fargol Mazaheri et al.   Nature Communications

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

LDL Receptor–Related Protein-1

(2013) Steven L. Gonias et al.   AMERICAN JOURNAL OF PATHOLOGY

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids

(2013) K Lauber et al.   CELL DEATH AND DIFFERENTIATION

Involvement of small GTPase RhoA in the regulation of superoxide production in BV2 cells in response to fibrillar Aβ peptides

(2013) Mi-Young Moon et al.   CELLULAR SIGNALLING

Multimolecular Signaling Complexes Enable Syk-Mediated Signaling of CD36 Internalization

(2013) Bryan Heit et al.   DEVELOPMENTAL CELL

The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons

(2013) V Lanoue et al.   MOLECULAR PSYCHIATRY

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

(2013) Zaida G Ramirez-Ortiz et al.   NATURE IMMUNOLOGY

CD36 Recruits α5β1 Integrin to Promote Cytoadherence of P. falciparum-Infected Erythrocytes

(2013) Shevaun P. Davis et al.   PLoS Pathogens

Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages

(2012) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG

(2012) Kazuhiko Namekata et al.   GENES TO CELLS

Jedi-1 and MEGF10 Signal Engulfment of Apoptotic Neurons through the Tyrosine Kinase Syk

(2012) J. L. Scheib et al.   JOURNAL OF NEUROSCIENCE

Cross Talk between Engulfment Receptors Stabilin-2 and Integrin  v 5 Orchestrates Engulfment of Phosphatidylserine-Exposed Erythrocytes

(2012) S. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

(2012) Ignacio J. Juncadella et al.   NATURE

Genetic Dissection of TAM Receptor-Ligand Interaction in Retinal Pigment Epithelial Cell Phagocytosis

(2012) Tal Burstyn-Cohen et al.   NEURON

Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis

(2012) Y. Hirose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

(2011) Mei He et al.   EMBO REPORTS

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

(2011) Nuria Martínez-Martín et al.   IMMUNITY

The RhoG/ELMO1/Dock180 Signaling Module Is Required for Spine Morphogenesis in Hippocampal Neurons

(2011) Jeong-Yoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras-related GTPases Rap1 and RhoA Collectively Induce the Phagocytosis of Serum-opsonized Zymosan Particles in Macrophages

(2011) Jae-Gyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoG is required for both FcγR- and CR3-mediated phagocytosis

(2011) George Tzircotis et al.   JOURNAL OF CELL SCIENCE

A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans

(2011) Hye Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1)

(2011) Miranda L. Curtiss et al.   MOLECULAR IMMUNOLOGY

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

PTTG induces EMT through integrin αVβ3-focal adhesion kinase signaling in lung cancer cells

(2011) P P Shah et al.   ONCOGENE

Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

(2011) Soumita Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis

(2010) Laurent Yvan-Charvet et al.   CIRCULATION RESEARCH

DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4

(2010) Fumiyuki Sanematsu et al.   CIRCULATION RESEARCH

Engulfment of Apoptotic Cells in C. elegans Is Mediated by Integrin α/SRC Signaling

(2010) Tsung-Yuan Hsu et al.   CURRENT BIOLOGY

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

(2010) Nora B Caberoy et al.   EMBO JOURNAL

MEGF10 functions as a receptor for the uptake of amyloid-β

(2010) Thoudam Debraj Singh et al.   FEBS LETTERS

Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo

(2010) Michael R. Elliott et al.   NATURE

Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor

(2010) Xiaochen Wang et al.   NATURE CELL BIOLOGY

Rac1 regulates cardiovascular development and postnatal function of endothelium

(2010) Lorna R. Fiedler   Cell Adhesion & Migration

Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences

(2009) R. William Vandivier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette Smoke Impairs Clearance of Apoptotic Cells through Oxidant-dependent Activation of RhoA

(2009) Tiffany R. Richens et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse

(2009) Yoichiro Uchida et al.   HEPATOLOGY

Signalling Pathway Involving GULP, MAPK and Rac1 for SR-BI-Induced Phagocytosis of Apoptotic Cells

(2009) Y. Osada et al.   JOURNAL OF BIOCHEMISTRY

Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages

(2009) S.-Y. Park et al.   JOURNAL OF CELL SCIENCE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor

(2009) Hsiao-Huei Wu et al.   NATURE NEUROSCIENCE

LRP1 Controls cPLA2 Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export

(2009) Li Zhou et al.   PLoS One

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

Undertaker, a Drosophila Junctophilin, Links Draper-Mediated Phagocytosis and Calcium Homeostasis

(2008) Leigh Cuttell et al.   CELL

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment

(2008) Seung-Yoon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages

(2008) Jill C. Todt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epidermal Growth Factor-Like Domain Repeat of Stabilin-2 Recognizes Phosphatidylserine during Cell Corpse Clearance

(2008) S.-Y. Park et al.   MOLECULAR AND CELLULAR BIOLOGY

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo

(2008) M. Laurin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain

(2008) Suhita Gayen Betal et al.   Translational Research