Mitochondrial aldehyde dehydrogenase and cardiac diseases

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

(2010) Samantha Perez-Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transgenic Overexpression of Aldehyde Dehydrogenase-2 Rescues Chronic Alcohol Intake–Induced Myocardial Hypertrophy and Contractile Dysfunction

(2009) Thomas A. Doser et al.   CIRCULATION

Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart

(2009) Jin Endo et al.   CIRCULATION RESEARCH

Mechanistic Insights Into Nitrite-Induced Cardioprotection Using an Integrated Metabolomic/Proteomic Approach

(2009) David H. Perlman et al.   CIRCULATION RESEARCH

Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism

(2009) Helmut K. Seitz et al.   Genes and Nutrition

Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2

(2009) Matteo Beretta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress

(2009) Shi-Yan Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCɛ) knockout mice

(2009) Grant R. Budas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Aldehyde Dehydrogenase 2 Ameliorates Acute Cardiac Toxicity of Ethanol

(2009) Heng Ma et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lessons From the Besotted Heart⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.

(2009) Joel S. Karliner   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ethanol metabolism in ALDH2 knockout mice – Blood acetate levels

(2009) Ameno Kiyoshi et al.   Legal Medicine

Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex

(2009) Jun Ren et al.   TOXICOLOGY LETTERS

Aldehyde Dehydrogenase 2 in Cardiac Protection: A New Therapeutic Target?

(2009) Grant R. Budas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Alcohol Flushing Response: An Unrecognized Risk Factor for Esophageal Cancer from Alcohol Consumption

(2009) Philip J Brooks et al.   PLOS MEDICINE

Alcohol in Moderation, Cardioprotection, and Neuroprotection: Epidemiological Considerations and Mechanistic Studies

(2008) Michael A. Collins et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

ALDH-2 deficiency increases cardiovascular oxidative stress---Evidence for indirect antioxidative properties

(2008) Philip Wenzel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal

(2008) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Long-Term Nitrate Use in Acute Myocardial Infarction (The Heart Institute of Japan, Department of Cardiology Nitrate Evaluation Program)

(2008) Takao Yamauchi et al.   CARDIOVASCULAR DRUGS AND THERAPY

Oxidative stress and left ventricular remodelling after myocardial infarction

(2008) M. Hori et al.   CARDIOVASCULAR RESEARCH

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

(2008) Satori A Marchitti et al.   Expert Opinion on Drug Metabolism & Toxicology

Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCε signaling and cardioprotection

(2008) Guang-Wu Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of ɛPKC and activation of aldehyde dehydrogenase 2

(2008) Eric N. Churchill et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity

(2008) I. Ohsawa et al.   JOURNAL OF NEUROSCIENCE

Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice

(2008) Akiko Matsumoto et al.   Pharmacogenetics and Genomics

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE

4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

(2007) G. Poli et al.   MEDICINAL RESEARCH REVIEWS