The nuclear lamina in health and disease

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder

(2016) Yuexia Wang et al.   JOURNAL OF CELL SCIENCE

A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds

(2016) Nard Kubben et al.   METHODS

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stress

(2015) Michael J. Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

(2015) Jop Kind et al.   CELL

Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping

(2015) Sigal Shachar et al.   CELL

Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos

(2015) Adriana Gonzalez-Sandoval et al.   CELL

Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing

(2015) D T Warren et al.   CELL DEATH AND DIFFERENTIATION

Nuclear membrane diversity: underlying tissue-specific pathologies in disease?

(2015) Howard J Worman et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear envelope and striated muscle diseases

(2015) Maria Chatzifrangkeskou et al.   CURRENT OPINION IN CELL BIOLOGY

DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome

(2015) Susana Gonzalo et al.   CURRENT OPINION IN CELL BIOLOGY

Nuclear lamins are not required for lamina-associated domain organization in mouse embryonic stem cells

(2015) M. Amendola et al.   EMBO REPORTS

Ameliorating pathogenesis by removing an exon containing a missense mutation: a potential exon-skipping therapy for laminopathies

(2015) J Scharner et al.   GENE THERAPY

Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins

(2015) Sandra Vidak et al.   GENES & DEVELOPMENT

Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B

(2015) Torunn Rønningen et al.   GENOME RESEARCH

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes

(2015) Elisa Cesarini et al.   JOURNAL OF CELL BIOLOGY

Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins

(2015) Jennifer C. Harr et al.   JOURNAL OF CELL BIOLOGY

A little sugar goes a long way: The cell biology of O-GlcNAc

(2015) Michelle R. Bond et al.   JOURNAL OF CELL BIOLOGY

Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans

(2015) A. Morales-Martinez et al.   JOURNAL OF CELL SCIENCE

Age-Related Lipid Metabolic Signature in HumanLMNA-Lipodystrophic Stem Cell-Derived Adipocytes

(2015) Patricia Sánchez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription

(2015) Honglei Zhao et al.   MOLECULAR CELL

Nuclear architecture dictates HIV-1 integration site selection

(2015) Bruna Marini et al.   NATURE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

(2015) Alexandre Chojnowski et al.   eLife

Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts

(2014) Diana Gabriel et al.   AGING CELL

Progeria: A Paradigm for Translational Medicine

(2014) Leslie B. Gordon et al.   CELL

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

Impact of Farnesylation Inhibitors on Survival in Hutchinson-Gilford Progeria Syndrome

(2014) Leslie B. Gordon et al.   CIRCULATION

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Phosphoinositide 3-Kinase Beta Protects Nuclear Envelope Integrity by Controlling RCC1 Localization and Ran Activity

(2014) Javier Redondo-Muñoz et al.   MOLECULAR AND CELLULAR BIOLOGY

BAF-1 mobility is regulated by environmental stresses

(2014) Daniel Z. Bar et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic identification of pathological lamin A interactors

(2014) Travis A. Dittmer et al.   MOLECULAR BIOLOGY OF THE CELL

Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations

(2014) Eivind Lund et al.   NUCLEIC ACIDS RESEARCH

Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells

(2014) Pierre Therizols et al.   SCIENCE

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

(2014) D. Larrieu et al.   SCIENCE

Nuclear Envelope Lamin-A Couples Actin Dynamics with Immunological Synapse Architecture and T Cell Activation

(2014) J. M. Gonzalez-Granado et al.   Science Signaling

Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

(2014) Indroneal Banerjee et al.   PLoS Genetics

Induced Pluripotent Stem Cells Reveal Functional Differences Between Drugs Currently Investigated in Patients With Hutchinson-Gilford Progeria Syndrome

(2014) Sophie Blondel et al.   Stem Cells Translational Medicine

Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans

(2014) Cristina González-Aguilera et al.   GENOME BIOLOGY

Stochastic genome-nuclear lamina interactions

(2014) Jop Kind et al.   Nucleus

Chromatin Position Effects Assayed by Thousands of Reporters Integrated in Parallel

(2013) Waseem Akhtar et al.   CELL

Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures

(2013) Brandon H. Toyama et al.   CELL

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

Genome Architecture: Domain Organization of Interphase Chromosomes

(2013) Wendy A. Bickmore et al.   CELL

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

(2013) Ricardo Villa-Bellosta et al.   CIRCULATION

Prelamin A Accelerates Vascular Calcification Via Activation of the DNA Damage Response and Senescence-Associated Secretory Phenotype in Vascular Smooth Muscle Cells

(2013) Yiwen Liu et al.   CIRCULATION RESEARCH

Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes

(2013) E. Lund et al.   GENOME RESEARCH

Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity

(2013) Marie-Elodie Cattin et al.   HUMAN MOLECULAR GENETICS

O-Linked β-N-Acetylglucosamine (O-GlcNAc) Regulates Emerin Binding to Barrier to Autointegration Factor (BAF) in a Chromatin- and Lamin B-enriched “Niche”

(2013) Jason M. Berk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Identification of mitochondrial dysfunction in Hutchinson–Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

(2013) José Rivera-Torres et al.   Journal of Proteomics

Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria

(2013) M. X. Ibrahim et al.   SCIENCE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery

(2013) Nikolaj Zuleger et al.   GENOME BIOLOGY

Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability

(2013) Arindam Das et al.   Nucleus

Lamins as mediators of oxidative stress

(2012) Tom Sieprath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

(2012) Joseph M. Zullo et al.   CELL

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery

(2012) Benjamin D. Towbin et al.   CELL

Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria

(2012) Baohua Liu et al.   Cell Metabolism

Nuclear damages and oxidative stress: new perspectives for laminopathies

(2012) G. Lattanzi et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

(2012) W. Meuleman et al.   GENOME RESEARCH

Lamin B Receptor Recognizes Specific Modifications of Histone H4 in Heterochromatin Formation

(2012) Yasuhiro Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sp1 Transcription Factor Interaction with Accumulated Prelamin A Impairs Adipose Lineage Differentiation in Human Mesenchymal Stem Cells: Essential Role of Sp1 in the Integrity of Lipid Vesicles

(2012) Garbiñe Ruiz de Eguino et al.   Stem Cells Translational Medicine

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

(2011) Vanja Pekovic et al.   AGING CELL

A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair

(2011) Ignacio Gonzalez-Suarez et al.   EMBO JOURNAL

Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

(2011) V. Cenni et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

(2011) Shane A. Richards et al.   HUMAN MOLECULAR GENETICS

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Suppression of Proliferative Defects Associated with Processing-defective Lamin A Mutants by hTERT or Inactivation of p53

(2008) Brian A. Kudlow et al.   MOLECULAR BIOLOGY OF THE CELL