DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

Frontotemporal Dementia Phenotype Associated with MAPT Gene Duplication

(2017) Anne Rovelet-Lecrux et al.   JOURNAL OF ALZHEIMERS DISEASE

Ageing of people with Down’s syndrome

(2016) Venusia Covelli et al.   INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH

DYRK protein kinases

(2015) Ulf Soppa et al.   CURRENT BIOLOGY

DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model

(2015) N. Kurabayashi et al.   EMBO REPORTS

Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A

(2015) Lucas M Bronicki et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DYRK1A mutations in two unrelated patients

(2015) Lyse Ruaud et al.   European Journal of Medical Genetics

Synthesis and molecular modelling studies of 8-arylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors

(2015) Yvonnick Loidreau et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Genetic dissection of the Down syndrome critical region

(2015) Xiaoling Jiang et al.   HUMAN MOLECULAR GENETICS

Dyrk1A phosphorylates parkin at Ser-131 and negatively regulates its ubiquitin E3 ligase activity

(2015) Eunju Im et al.   JOURNAL OF NEUROCHEMISTRY

A novel DYRK1A (Dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologiesin vitro

(2015) Séverine Coutadeur et al.   JOURNAL OF NEUROCHEMISTRY

Chromatin-wide Profiling of DYRK1A Reveals a Role as a Gene-Specific RNA Polymerase II CTD Kinase

(2015) Chiara Di Vona et al.   MOLECULAR CELL

Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID

(2015) B W M van Bon et al.   MOLECULAR PSYCHIATRY

DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

(2015) Ramzi Abbassi et al.   PHARMACOLOGY & THERAPEUTICS

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ

(2015) Rie Sonamoto et al.   Scientific Reports

DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

(2015) Sònia Najas et al.   EBioMedicine

Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors

(2015) Katharina Rüben et al.   PLoS One

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

(2015) Pavel V. Belichenko et al.   PLoS One

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1and Cyclin D1 and induces cell cycle exit and neuronal differentiation

(2014) Ulf Soppa et al.   CELL CYCLE

DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies

(2014) Walter Becker et al.   CNS & Neurological Disorders-Drug Targets

Human CDC2-Like Kinase 1 (CLK1): A Novel Target for Alzheimer’s Disease

(2014) Princi Jain et al.   CURRENT DRUG TARGETS

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II

(2014) Alicia Foucourt et al.   MOLECULES

Domains of genome-wide gene expression dysregulation in Down’s syndrome

(2014) Audrey Letourneau et al.   NATURE

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

(2014) Benoit Souchet et al.   NEUROBIOLOGY OF DISEASE

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome

(2014) Susana García-Cerro et al.   PLoS One

DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors

(2014) Cristina Grau et al.   Frontiers in Cellular Neuroscience

Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4

(2014) Christian Schmitt et al.   ACS Medicinal Chemistry Letters

Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells

(2014) Chen Chen et al.   Nature Communications

Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase

(2014) Chun-Kan Chen et al.   Nature Communications

Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011

(2014) Kyla H Thomas et al.   BMC Pharmacology & Toxicology

New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome

(2014) Joongkyu Park et al.   Experimental Neurobiology

Cellular targets for the beneficial actions of tea polyphenols

(2013) Mario Lorenz   AMERICAN JOURNAL OF CLINICAL NUTRITION

Synthesis of novel 7-substituted pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases

(2013) Emmanuel Deau et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315

(2013) Thomas C. Coombs et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

People with intellectual disability: What do we know about adulthood and life expectancy?

(2013) A.M.W. Coppus   Developmental Disabilities Research Reviews

Atypical aging in down syndrome

(2013) Warren B. Zigman   Developmental Disabilities Research Reviews

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

(2013) Youssef Hibaoui et al.   EMBO Molecular Medicine

Mechanism of dual specificity kinase activity of DYRK1A

(2013) Agnes Walte et al.   FEBS Journal

Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells

(2013) N. Kurabayashi et al.   GENES & DEVELOPMENT

Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome

(2013) Ariadna Laguna et al.   HUMAN MOLECULAR GENETICS

Development of DANDYs, New 3,5-Diaryl-7-azaindoles Demonstrating Potent DYRK1A Kinase Inhibitory Activity

(2013) Stéphanie Gourdain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)

(2013) Wojciech Kaczmarski et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle

(2013) Jia-Yun Chen et al.   MOLECULAR CELL

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A

(2013) Meritxell Pons-Espinal et al.   NEUROBIOLOGY OF DISEASE

Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates

(2013) Woo-Joo Song et al.   NEUROSCIENCE LETTERS

Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion

(2013) Yuying Liu et al.   NUCLEIC ACIDS RESEARCH

Dyrk1A Is Dynamically Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome

(2013) Gloria Arque et al.   PLoS One

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

(2013) Meera Soundararajan et al.   STRUCTURE

Recent developments of protein kinase inhibitors as potential AD therapeutics

(2013) Volkmar Tell et al.   Frontiers in Cellular Neuroscience

Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

(2012) Breland Smith et al.   ACS Chemical Neuroscience

Copy number variations involving the microtubule-associated protein tau in human diseases: Figure 1

(2012) Anne Rovelet-Lecrux et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons

(2012) M. Martinez de Lagran et al.   CEREBRAL CORTEX

Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP

(2012) J. Park et al.   JOURNAL OF CELL SCIENCE

TheDYRK1Agene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy

(2012) Jean-Benoît Courcet et al.   JOURNAL OF MEDICAL GENETICS

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

(2012) Bozena Mazur-Kolecka et al.   JOURNAL OF NEUROSCIENCE RESEARCH

DYRK1A Kinase Inhibitors with Emphasis on Cancer

(2012) A. Ionescu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Dyrk1A, a Serine/Threonine Kinase, is Involved in ERK and Akt Activation in the Brain of Hyperhomocysteinemic Mice

(2012) Sabiha Abekhoukh et al.   MOLECULAR NEUROBIOLOGY

DYRK1A: A master regulatory protein controlling brain growth

(2012) Fayçal Guedj et al.   NEUROBIOLOGY OF DISEASE

Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome

(2012) Xavier Altafaj et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation by Dyrk1A of Clathrin Coated Vesicle-Associated Proteins: Identification of the Substrate Proteins and the Effects of Phosphorylation

(2012) Noriko Murakami et al.   PLoS One

Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders

(2012) B. J. O'Roak et al.   SCIENCE

Synaptic Vesicle Endocytosis

(2012) Y. Saheki et al.   Cold Spring Harbor Perspectives in Biology

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

(2012) Vassilios Myrianthopoulos et al.   ACS Medicinal Chemistry Letters

DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation

(2011) Yoshihiko Miyata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)

(2011) Andrew S. Rosenthal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

(2011) Oleg Fedorov et al.   CHEMISTRY & BIOLOGY

Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly

(2011) BWM van Bon et al.   CLINICAL GENETICS

Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling

(2011) B. Hammerle et al.   DEVELOPMENT

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents

(2011) Pamela Kassis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A kinase shRNA screen links LATS2 and the pRB tumor suppressor

(2011) K. Tschop et al.   GENES & DEVELOPMENT

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

Synthesis, Protein Kinase Inhibitory Potencies, and in Vitro Antiproliferative Activities of Meridianin Derivatives

(2011) Francis Giraud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dyrk1a activates antioxidant NQO1 expression through an ERK1/2–Nrf2 dependent mechanism

(2011) Christophe Noll et al.   MOLECULAR GENETICS AND METABOLISM

Overexpression of Dyrk1A Causes the Defects in Synaptic Vesicle Endocytosis

(2011) Yoonju Kim et al.   NEUROSIGNALS

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

(2011) W. Qian et al.   NUCLEIC ACIDS RESEARCH

β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

(2011) Danielle Frost et al.   PLoS One

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

(2011) Raymond Wong et al.   Retrovirology

Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins

(2011) Terry S. Elton et al.   RNA Biology

Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

(2010) Tatyana Adayev et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome

(2010) Arnaud Duchon et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

(2010) Tao Yu et al.   BRAIN RESEARCH

Cdc2-like Kinase 2 Is an Insulin-Regulated Suppressor of Hepatic Gluconeogenesis

(2010) Joseph T. Rodgers et al.   Cell Metabolism

Non-ATP Competitive Protein Kinase Inhibitors

(2010) L. Garuti et al.   CURRENT MEDICINAL CHEMISTRY

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

(2010) Sergi Aranda et al.   FASEB JOURNAL

MNB/DYRK1A as a multiple regulator of neuronal development

(2010) Francisco J. Tejedor et al.   FEBS Journal

Activation, regulation, and inhibition of DYRK1A

(2010) Walter Becker et al.   FEBS Journal

The role of DYRK1A in neurodegenerative diseases

(2010) Jerzy Wegiel et al.   FEBS Journal

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

(2010) Xiumei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

(2010) Joongkyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

(2010) Young Shin Ryu et al.   JOURNAL OF NEUROCHEMISTRY

Dyrk1A Overexpression Inhibits Proliferation and Induces Premature Neuronal Differentiation of Neural Progenitor Cells

(2010) O. Yabut et al.   JOURNAL OF NEUROSCIENCE

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

DYRK1A and Glycogen Synthase Kinase 3 , a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping

(2010) N. Kurabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome

(2010) Andrea Contestabile et al.   PROGRESS IN NEUROBIOLOGY

Astrocytes and human cognition: Modeling information integration and modulation of neuronal activity

(2010) Alfredo Pereira et al.   PROGRESS IN NEUROBIOLOGY

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

Dyrk1A Binds to Multiple Endocytic Proteins Required for Formation of Clathrin-Coated Vesicles

(2009) Noriko Murakami et al.   BIOCHEMISTRY

QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

(2009) Kyung Ah Koo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)

(2009) Bryan T. Mott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

(2009) Julien Laffaire et al.   BMC GENOMICS

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

(2009) César Sánchez et al.   CHEMICAL COMMUNICATIONS

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

(2009) Nora Göckler et al.   FEBS Journal

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

(2009) Aude-Marie Lepagnol-Bestel et al.   HUMAN MOLECULAR GENETICS

ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage

(2009) Naoe Taira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonprimed and DYRK1A-primed GSK3 -phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons

(2009) T. M. E. Scales et al.   JOURNAL OF CELL SCIENCE

Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A

(2009) J. Fernandez-Martinez et al.   JOURNAL OF CELL SCIENCE

Heteroaromatic Rings of the Future

(2009) William R. Pitt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres

(2009) Randal X. Moldrich et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice

(2009) Glòria Arqué et al.   NEUROBIOLOGY OF DISEASE

Aneuploidy: From a Physiological Mechanism of Variance to Down Syndrome

(2009) Mara Dierssen et al.   PHYSIOLOGICAL REVIEWS

Tea catechins’ affinity for human cannabinoid receptors

(2009) G. Korte et al.   PHYTOMEDICINE

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome

(2008) Jon Ortiz-Abalia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly

(2008) Rikke S. Møller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1

(2008) Barbara Maenz et al.   BMC MOLECULAR BIOLOGY

The Protein Kinase DYRK1A Regulates Caspase-9-Mediated Apoptosis during Retina Development

(2008) Ariadna Laguna et al.   DEVELOPMENTAL CELL

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development

(2008) Barbara Hämmerle et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

(2008) Anne Seifert et al.   FEBS Journal

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

(2008) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome

(2008) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex†

(2008) Aude Echalier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sprouty2-Mediated Inhibition of Fibroblast Growth Factor Signaling Is Modulated by the Protein Kinase DYRK1A

(2008) S. Aranda et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome

(2008) X. Altafaj et al.   NEUROBIOLOGY OF DISEASE

The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

(2008) J.H. Sitz et al.   NEUROSCIENCE

Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

(2008) Glòria Arqué et al.   PLoS One

Cellular reactions to gene dosage imbalance: genomic, transcriptomic and proteomic effects

(2008) Reiner A. Veitia et al.   TRENDS IN GENETICS

NFAT signaling in neural development and axon growth

(2007) Tuan Nguyen et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY