Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

(2009) Kyung Ah Koo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

(2009) Aude-Marie Lepagnol-Bestel et al.   HUMAN MOLECULAR GENETICS

DYRK1A Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy

(2009) Christian Kuhn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology

(2009) Tao Liu et al.   GENOME BIOLOGY

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

(2008) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly

(2008) Rikke S. Møller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Protein Kinase DYRK1A Regulates Caspase-9-Mediated Apoptosis during Retina Development

(2008) Ariadna Laguna et al.   DEVELOPMENTAL CELL

The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development

(2008) Barbara Hämmerle et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

(2008) Anne Seifert et al.   FEBS Journal

The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

(2008) J.H. Sitz et al.   NEUROSCIENCE

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY