A novel DYRK1A (Dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologiesin vitro

DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies

(2014) Walter Becker et al.   CNS & Neurological Disorders-Drug Targets

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology

(2014) Claire H. Michel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model

(2012) J. Brouillette et al.   JOURNAL OF NEUROSCIENCE

Leucettines, a family of pharmacological inhibitors of DYRKs & CLKs kinases derived from the marine sponge Leucettamine B

(2012) T Tahtouh et al.   PLANTA MEDICA

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

(2011) Mansour Debdab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

(2011) W. Qian et al.   NUCLEIC ACIDS RESEARCH

β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

(2011) Danielle Frost et al.   PLoS One

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

The role of DYRK1A in neurodegenerative diseases

(2010) Jerzy Wegiel et al.   FEBS Journal

Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression

(2010) Yun Li et al.   NEUROPHARMACOLOGY

DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort

(2009) José Luis Vázquez-Higuera et al.   BMC Medical Genetics

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

(2009) Nora Göckler et al.   FEBS Journal

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

(2008) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

Tau as a biomarker of neurodegenerative diseases

(2008) Susanna Schraen-Maschke et al.   Biomarkers in Medicine

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

(2008) Nicolas Sergeant et al.   Expert Review of Proteomics

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

(2008) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Etazolate, a neuroprotective drug linking GABAAreceptor pharmacology to amyloid precursor protein processing

(2008) Maryline Marcade et al.   JOURNAL OF NEUROCHEMISTRY

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY