Mechanism of dual specificity kinase activity of DYRK1A

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

(2013) Francesca Siepi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

(2013) Meera Soundararajan et al.   STRUCTURE

Deep Evolutionary Conservation of an Intramolecular Protein Kinase Activation Mechanism

(2012) Jingfen Han et al.   PLoS One

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

(2012) Vera V. Saul et al.   Journal of Molecular Cell Biology

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

(2011) Oleg Fedorov et al.   CHEMISTRY & BIOLOGY

Form of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hippocampal progenitors, and some cholinergic axon terminals

(2011) E. Kida et al.   NEUROSCIENCE

MNB/DYRK1A as a multiple regulator of neuronal development

(2010) Francisco J. Tejedor et al.   FEBS Journal

Activation, regulation, and inhibition of DYRK1A

(2010) Walter Becker et al.   FEBS Journal

Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity

(2010) Chrisovalantis Papadopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Mutants of the TCR-Mediated p38α Alternative Activation Site Show Changes in the Phosphorylation Lip and DEF Site Formation

(2010) Netanel Tzarum et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of a Domain That Transiently Converts Class 2 DYRKs into Intramolecular Tyrosine Kinases

(2010) R. Kinstrie et al.   Science Signaling

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

Insights into protein kinase regulation and inhibition by large scale structural comparison

(2009) Jeyanthy Eswaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)

(2009) Bryan T. Mott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

(2009) Nora Göckler et al.   FEBS Journal

Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation

(2009) P. A. Lochhead   Science Signaling

The selectivity of inhibitors of protein kinase CK2: an update

(2008) Mario A. Pagano et al.   BIOCHEMICAL JOURNAL

Constitutive Activity of JNK2α2 Is Dependent on a Unique Mechanism of MAPK Activation

(2008) Ryan T. Nitta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY