Activation, regulation, and inhibition of DYRK1A

The role of DYRK1A in neurodegenerative diseases

(2010) Jerzy Wegiel et al.   FEBS Journal

Direct Association of Sprouty-related Protein with an EVH1 Domain (SPRED) 1 or SPRED2 with DYRK1A Modifies Substrate/Kinase Interactions

(2010) Dan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenovirus Type 5 E1A and E6 Proteins of Low-Risk Cutaneous Beta-Human Papillomaviruses Suppress Cell Transformation through Interaction with FOXK1/K2 Transcription Factors

(2010) J. Komorek et al.   JOURNAL OF VIROLOGY

DYRK1A and Glycogen Synthase Kinase 3 , a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping

(2010) N. Kurabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of a Domain That Transiently Converts Class 2 DYRKs into Intramolecular Tyrosine Kinases

(2010) R. Kinstrie et al.   Science Signaling

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

(2009) Kyung Ah Koo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)

(2009) Bryan T. Mott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regulation of MBK-2/DYRK by CDK-1 and the Pseudophosphatases EGG-4 and EGG-5 during the Oocyte-to-Embryo Transition

(2009) Ken Chih-Chien Cheng et al.   CELL

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans

(2009) Jean M. Parry et al.   CURRENT BIOLOGY

Advances in the development of kinase inhibitor therapeutics for Alzheimer's disease

(2009) Mary J. Savage et al.   DRUG DEVELOPMENT RESEARCH

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

(2009) Nora Göckler et al.   FEBS Journal

Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

(2009) Youngkyun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DYRK1A Is a Novel Negative Regulator of Cardiomyocyte Hypertrophy

(2009) Christian Kuhn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonprimed and DYRK1A-primed GSK3 -phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons

(2009) T. M. E. Scales et al.   JOURNAL OF CELL SCIENCE

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Truncation of the Down Syndrome Candidate Gene DYRK1A in Two Unrelated Patients with Microcephaly

(2008) Rikke S. Møller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The selectivity of inhibitors of protein kinase CK2: an update

(2008) Mario A. Pagano et al.   BIOCHEMICAL JOURNAL

Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1

(2008) Barbara Maenz et al.   BMC MOLECULAR BIOLOGY

The Protein Kinase DYRK1A Regulates Caspase-9-Mediated Apoptosis during Retina Development

(2008) Ariadna Laguna et al.   DEVELOPMENTAL CELL

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

(2008) Anne Seifert et al.   FEBS Journal

Increased Dosage of Dyrk1A Alters Alternative Splicing Factor (ASF)-regulated Alternative Splicing of Tau in Down Syndrome

(2008) Jianhua Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-γ Expression and Adipocyte Differentiation

(2008) Kye Won Park et al.   MOLECULAR ENDOCRINOLOGY

The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4

(2008) J.H. Sitz et al.   NEUROSCIENCE