Dyrk1A phosphorylates parkin at Ser-131 and negatively regulates its ubiquitin E3 ligase activity

New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome

(2014) Joongkyu Park et al.   Experimental Neurobiology

Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity

(2013) Ji-Yun Chung et al.   LABORATORY INVESTIGATION

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP

(2012) J. Park et al.   JOURNAL OF CELL SCIENCE

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

(2012) Ji Won Um et al.   JOURNAL OF NEUROSCIENCE RESEARCH

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Posttranslational Modifications as Versatile Regulators of Parkin Function

(2011) E. Rubio de la Torre et al.   CURRENT MEDICINAL CHEMISTRY

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

(2010) Joongkyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

(2010) Young Shin Ryu et al.   JOURNAL OF NEUROCHEMISTRY

Parkin Directly Modulates 26S Proteasome Activity

(2010) J. W. Um et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

(2010) H. S. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

(2009) Ventzislava A. Hristova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

(2008) Jerzy Wegiel et al.   ACTA NEUROPATHOLOGICA

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY