4.7 Article

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 27, Pages 4118-4120

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b905068j

Keywords

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Funding

  1. Spanish Ministry of Science and Innovation [BFU2006-00404]
  2. Ministry of Health, Spain [ISCIII-RETIC RD06/0020/0026, EU FP6]
  3. ActinoGen [005224]

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We report the generation of novel glycosylated indolocarbazoles by combinatorial biosynthesis, and the identification of two novel potent and selective compounds inhibitors of JAK2 and Ikkb kinases.

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