Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

(2013) Ludovic Sauguet et al.   Nature Communications

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

(2012) Jianjun Pan et al.   STRUCTURE

Size matters in activation/inhibition of ligand-gated ion channels

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Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

(2011) Tanya L. Wallace et al.   BIOCHEMICAL PHARMACOLOGY

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

(2011) Shu-Xing Li et al.   NATURE NEUROSCIENCE

A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors

(2011) Marijke Brams et al.   PLOS BIOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

General Anesthetics Have Additive Actions on Three Ligand Gated Ion Channels

(2009) Andrew Jenkins et al.   ANESTHESIA AND ANALGESIA

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

(2009) Ryan E Hibbs et al.   EMBO JOURNAL

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Positive Allosteric Modulation of the  7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment

(2008) D. Bertrand et al.   MOLECULAR PHARMACOLOGY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

An automated system for intracellular and intranuclear injection

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