The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold

An Internally Modulated, Thermostable, pH-sensitive Cys Loop Receptor from the Hydrothermal Vent WormAlvinella pompejana

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Mechanism of activation of the prokaryotic channel ELIC by propylamine: A single-channel study

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The Role of Intracellular Linkers in Gating and Desensitization of Human Pentameric Ligand-Gated Ion Channels

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Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel

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Stabilization of the GluCl Ligand-Gated Ion Channel in the Presence and Absence of Ivermectin

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Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

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Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography

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Desensitization Mechanism in Prokaryotic Ligand-gated Ion Channel

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Myasthenic syndrome AChRα C-loop mutant disrupts initiation of channel gating

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The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

(2012) Andrew J. Thompson et al.   NEUROPHARMACOLOGY

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

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Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations

(2012) Iwan Zimmermann et al.   PLOS BIOLOGY

Structure of the M2 Transmembrane Segment of GLIC, a Prokaryotic Cys Loop Receptor Homologue fromGloeobacter violaceus, Probed by Substituted Cysteine Accessibility

(2011) Rishi B. Parikh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes

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Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC

(2011) Iwan Zimmermann et al.   PLOS BIOLOGY

Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Bridging the Gap between Structural Models of Nicotinic Receptor Superfamily Ion Channels and Their Corresponding Functional States

(2010) Giovanni Gonzalez-Gutierrez et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

(2010) Ricarda J C Hilf et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Decremental Response to High-Frequency Trains of Acetylcholine Pulses but Unaltered Fractional Ca2+Currents in a Panel of “Slow-Channel Syndrome” Nicotinic Receptor Mutants

(2009) Sergio Elenes et al.   JOURNAL OF GENERAL PHYSIOLOGY

Detection and trapping of intermediate states priming nicotinic receptor channel opening

(2009) Nuriya Mukhtasimova et al.   NATURE

Haemonchus contortus Acetylcholine Receptors of the DEG-3 Subfamily and Their Role in Sensitivity to Monepantel

(2009) Lucien Rufener et al.   PLoS Pathogens

Protons Act as a Transmitter for Muscle Contraction in C. elegans

(2008) Asim A. Beg et al.   CELL

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE