Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties

Chemical Biology Probes from Advanced DNA-encoded Libraries

(2016) Hazem Salamon et al.   ACS Chemical Biology

Novel PTP1B inhibitors identified by DNA display of fragment pairs

(2016) Sofia Barluenga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical Space of DNA-Encoded Libraries

(2016) Raphael M. Franzini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library

(2015) Raphael M. Franzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules

(2015) Jean-Pierre Daguer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

(2015) Raphael M. Franzini et al.   CHEMICAL COMMUNICATIONS

Novel selection methods for DNA-encoded chemical libraries

(2015) Alix I Chan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

PNA-encoded chemical libraries

(2015) Claudio Zambaldo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel encoding methods for DNA-templated chemical libraries

(2015) Gang Li et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

(2015) Florent Samain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Photoaffinity labeling of transcription factors by DNA-templated crosslinking

(2015) Ying Liu et al.   Chemical Science

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules

(2015) J.-P. Daguer et al.   Chemical Science

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

(2015) Alexander Litovchick et al.   Scientific Reports

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion byPseudomonas aeruginosa

(2014) Alexandre Novoa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets

(2014) Peng Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

(2014) Christopher S. Kollmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PNA-Encoded Synthesis (PES) of a 10 000-Member Hetero-Glycoconjugate Library and Microarray Analysis of Diverse Lectins

(2014) Alexandre Novoa et al.   CHEMBIOCHEM

A DNA-templated synthesis of encoded small molecules by DNA self-assembly

(2014) Cheng Cao et al.   CHEMICAL COMMUNICATIONS

Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates

(2014) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

(2014) Aidan G Gilmartin et al.   Nature Chemical Biology

Irreversible kinase inhibitors gain traction

(2013) Katharine Sanderson   NATURE REVIEWS DRUG DISCOVERY

Selective affinity-based probe for oncogenic kinases suitable for live cell imaging

(2013) Claudio Zambaldo et al.   Chemical Science

Expanding the Scope of PNA-Encoded Synthesis (PES): Mtt-Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity-Generating Reactions

(2012) Dalila Chouikhi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library

(2012) Markus Leimbacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate-Based Inhibitors

(2012) Loek T. M. van Wandelen et al.   ChemMedChem

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles

(2012) George Georghiou et al.   Nature Chemical Biology

Highly Parallel Translation of DNA Sequences into Small Molecules

(2012) Rebecca M. Weisinger et al.   PLoS One

Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

(2011) Nina Svensen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

(2011) Mihai Ciobanu et al.   CHEMICAL COMMUNICATIONS

Decoding a PNA Encoded Peptide Library by PCR: The Discovery of New Cell Surface Receptor Ligands

(2011) Nina Svensen et al.   CHEMISTRY & BIOLOGY

Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent Inhibitors

(2011) Emeline Leproult et al.   JOURNAL OF MEDICINAL CHEMISTRY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries

(2011) Jean-Pierre Daguer et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles

(2011) Jean Pierre Daguer et al.   Chemical Science

Combinatorial Self-Assembly of Glycan Fragments into Microarrays

(2010) Kuo-Ting Huang et al.   CHEMBIOCHEM

In Vivo Efficacy of Natural Product-Inspired Irreversible Kinase Inhibitors

(2010) Sofia Barluenga et al.   CHEMBIOCHEM

In VitroSelection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

(2010) Ralph E. Kleiner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases

(2009) Rajamalleswaramma Jogireddy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Covalent Modifiers: An Orthogonal Approach to Drug Design

(2009) Michele H. Potashman et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

(2009) Margit Haahr Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

A Portable Albumin Binder from a DNA-Encoded Chemical Library

(2008) Christoph E. Dumelin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions

(2008) Fabian Buller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

(2008) Stephen D. Barrett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular modeling and crystal structure of ERK2–hypothemycin complexes

(2008) Giulio Rastelli et al.   JOURNAL OF STRUCTURAL BIOLOGY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA