Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

(2014) Lourdes Encinas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates

(2014) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Real-Time Detection of Transcription Factors Using Target-Converted Helicase-Dependent Amplification Assay with Zero-Background Signal

(2013) Anping Cao et al.   ANALYTICAL CHEMISTRY

Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry

(2013) Gang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

(2013) Jeremy S. Disch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endonucleolytic Inhibition Assay of DNA/Fok I Transducer as a Sensitive Platform for Homogeneous Fluorescence Detection of Small Molecule–Protein Interactions

(2012) Zhen Zhen et al.   ANALYTICAL CHEMISTRY

Protein Detection Based on Small Molecule-Linked DNA

(2012) Ya Cao et al.   ANALYTICAL CHEMISTRY

Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA

(2012) Xiaofeng Wei et al.   CHEMICAL COMMUNICATIONS

Terminal Protection of Small Molecule-Linked DNA: A Versatile Biosensor Platform for Protein Binding and Gene Typing Assay

(2011) Zhan Wu et al.   ANALYTICAL CHEMISTRY

Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

(2011) Nina Svensen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

20 years of DNA-encoded chemical libraries

(2011) Luca Mannocci et al.   CHEMICAL COMMUNICATIONS

Small-molecule discovery from DNA-encoded chemical libraries

(2011) Ralph E. Kleiner et al.   CHEMICAL SOCIETY REVIEWS

Decoding a PNA Encoded Peptide Library by PCR: The Discovery of New Cell Surface Receptor Ligands

(2011) Nina Svensen et al.   CHEMISTRY & BIOLOGY

DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles

(2011) Jean Pierre Daguer et al.   Chemical Science

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

(2010) Fabian Buller et al.   ACS Chemical Biology

Sensitive and Visual Detection of Sequence-Specific DNA-Binding Protein via a Gold Nanoparticle-Based Colorimetric Biosensor

(2010) Li-Juan Ou et al.   ANALYTICAL CHEMISTRY

DNA as a Versatile Chemical Component for Catalysis, Encoding, and Stereocontrol

(2010) Scott K. Silverman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selecting chemicals: the emerging utility of DNA-encoded libraries

(2010) Matthew A. Clark   CURRENT OPINION IN CHEMICAL BIOLOGY

In VitroSelection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

(2010) Ralph E. Kleiner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment

(2010) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition

(2009) Fabian Buller et al.   CHEMISTRY & BIOLOGY

Reactivity-Dependent PCR: Direct, Solution-Phasein VitroSelection for Bond Formation

(2009) David J. Gorin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

(2009) Margit Haahr Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Terminal Protection of Small-Molecule-Linked DNA for Sensitive Electrochemical Detection of Protein Binding via Selective Carbon Nanotube Assembly

(2009) Zhan Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions

(2008) Fabian Buller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable forin VitroSelection

(2008) Brian N. Tse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA