Journal
CHEMBIOCHEM
Volume 15, Issue 14, Pages 2058-2065Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201402280
Keywords
DNA display; glycan array; glycopeptides; microarrays; multivalency; PNA
Funding
- European Research Council [ERC 201749]
- Swiss National Science Foundation [200021_143247]
- Swiss National Science Foundation (SNF) [200021_143247] Funding Source: Swiss National Science Foundation (SNF)
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Identification of selective and synthetically tractable ligands to glycan-binding proteins is important in glycoscience. Carbohydrate arrays have had a tremendous impact on profiling glycan-binding proteins and as analytical tools. We report a highly miniaturized synthetic format to access nucleic-acid-encoded hetero-glycoconjugate libraries with an unprecedented diversity in the combinations of glycans, linkers, and capping groups. Novel information about plant and bacterial lectin specificity was obtained by microarray profiling, and we show that a ligand identified on the array can be converted to a high-affinity soluble ligand by straightforward chemistry.
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