Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

(2015) Moreno Wichert et al.   Nature Chemistry

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules

(2015) J.-P. Daguer et al.   Chemical Science

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

(2014) Christopher S. Kollmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A DNA-templated synthesis of encoded small molecules by DNA self-assembly

(2014) Cheng Cao et al.   CHEMICAL COMMUNICATIONS

Nucleic Acid-tagged Peptides: Encoding Libraries and Controlling Dimerization and Conformation

(2014) Kalyan K. Sadhu et al.   CHIMIA

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

(2014) Lourdes Encinas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

(2013) Jeremy S. Disch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multistep DNA-Templated Synthesis Using a Universal Template

(2013) Yizhou Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library

(2012) Markus Leimbacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

(2011) Nina Svensen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Decoding a PNA Encoded Peptide Library by PCR: The Discovery of New Cell Surface Receptor Ligands

(2011) Nina Svensen et al.   CHEMISTRY & BIOLOGY

DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles

(2011) Jean Pierre Daguer et al.   Chemical Science

Isolation of a Small-Molecule Inhibitor of the Antiapoptotic Protein Bcl-xL from a DNA-Encoded Chemical Library

(2010) Samu Melkko et al.   ChemMedChem

In VitroSelection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

(2010) Ralph E. Kleiner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

(2009) Margit Haahr Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA