Exosomes as Novel Regulators of Adult Neurogenic Niches

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

(2015) Bence György et al.   Annual Review of Pharmacology and Toxicology

Targeting Cancer Stem Cells: Promises and Challenges

(2015) Jan Dominik Kuhlmann et al.   Anti-Cancer Agents in Medicinal Chemistry

RNA interference machinery-mediated gene regulation in mouse adult neural stem cells

(2015) Filippo M. Cernilogar et al.   BMC NEUROSCIENCE

Diagnostic and therapeutic potentials of exosomes in CNS diseases

(2015) Ivana Kawikova et al.   BRAIN RESEARCH

Classic and novel stem cell niches in brain homeostasis and repair

(2015) Ruihe Lin et al.   BRAIN RESEARCH

Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism

(2015) Stefania Raimondo et al.   Cell Communication and Signaling

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

(2015) Thanh-Huyen Tran et al.   CLINICAL IMMUNOLOGY

It Takes a Village: Constructing the Neurogenic Niche

(2015) Christopher S. Bjornsson et al.   DEVELOPMENTAL CELL

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease

(2015) Dimitrios Kapogiannis et al.   FASEB JOURNAL

Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: Aldolase C As a Potential Biomarker

(2015) Estibaliz Ampuero et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response

(2015) Ley-Hian Low et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Can Parkinson’s disease be cured by stimulating neurogenesis?

(2015) Thomas Foltynie   JOURNAL OF CLINICAL INVESTIGATION

Detection of exosomal prions in blood by immunochemistry techniques

(2015) Francesca Properzi et al.   JOURNAL OF GENERAL VIROLOGY

miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction

(2015) M. E. Woodbury et al.   JOURNAL OF NEUROSCIENCE

Regional and Stage-Specific Effects of Prospectively Purified Vascular Cells on the Adult V-SVZ Neural Stem Cell Lineage

(2015) E. E. Crouch et al.   JOURNAL OF NEUROSCIENCE

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

The vascular niche in adult neurogenesis

(2015) Tamar Licht et al.   MECHANISMS OF DEVELOPMENT

Interplay Between Exosomes, microRNAs and Toll-Like Receptors in Brain Disorders

(2015) Vera Paschon et al.   MOLECULAR NEUROBIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Molecular mechanisms in the regulation of adult neurogenesis during stress

(2015) Martin Egeland et al.   NATURE REVIEWS NEUROSCIENCE

miR-29c in urinary exosomes as predictor of early renal fibrosis in lupus nephritis

(2015) Cristina Solé et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Transiently impaired neurogenesis in MPTP mouse model of Parkinson's disease

(2015) Xi Jun He et al.   NEUROTOXICOLOGY

The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks

(2015) Dasiel O. Borroto-Escuela et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice

(2015) Hong Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

(2015) Toshihide Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF

(2015) Elizabeth D. Kirby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of exosomes during epithelial–mesenchymal transition and cancer progression

(2015) David W. Greening et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network

(2015) Márcia C. T. Santos et al.   STEM CELLS

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

An updated role of microRNA-124 in central nervous system disorders: a review

(2015) Yang Sun et al.   Frontiers in Cellular Neuroscience

Adult Neurogenesis in Humans

(2015) Olaf Bergmann et al.   Cold Spring Harbor Perspectives in Biology

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

Neurogenesis in the Adult Hippocampus

(2015) Gerd Kempermann et al.   Cold Spring Harbor Perspectives in Biology

miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes

(2015) C Mollinari et al.   Cell Death & Disease

Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia

(2015) Insaf Bahrini et al.   Scientific Reports

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

Postnatal Loss of Hap1 Reduces Hippocampal Neurogenesis and Causes Adult Depressive-Like Behavior in Mice

(2015) Jianxing Xiang et al.   PLoS Genetics

Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation

(2015) Brigid Ryan et al.   Frontiers in Molecular Neuroscience

Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival

(2015) Laurent Muller et al.   OncoImmunology

Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function

(2015) Jian Zhang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

(2015) Seiji Yamamoto et al.   Scientific Reports

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Plasma biomarker discovery in preeclampsia using a novel differential isolation technology for circulating extracellular vesicles

(2014) Kok Hian Tan et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

The interaction between microglia and neural stem/precursor cells

(2014) Peng Su et al.   BRAIN RESEARCH BULLETIN

Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways

(2014) Timothy H. Ung et al.   CANCER SCIENCE

Axonal Control of the Adult Neural Stem Cell Niche

(2014) Cheuk Ka Tong et al.   Cell Stem Cell

Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression

(2014) Jaclyn Nicole Le Grand et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exosomes in Neurologic and Psychiatric Disorders

(2014) Irene Tsilioni et al.   CLINICAL THERAPEUTICS

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Serotonin stimulates secretion of exosomes from microglia cells

(2014) Konstantin Glebov et al.   GLIA

Astrocytes shed extracellular vesicles that contain fibroblast growth factor-2 and vascular endothelial growth factor

(2014) Patrizia Proia et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neural stem cell-derived exosomes mediate viral entry

(2014) Brian Sims et al.   International Journal of Nanomedicine

The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release

(2014) C. A. Escudero et al.   JOURNAL OF CELL SCIENCE

Exosomes from Bronchoalveolar Fluid of Tolerized Mice Prevent Allergic Reaction

(2014) N. Prado et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer

(2014) J. M. Pitt et al.   JOURNAL OF IMMUNOLOGY

Exosomes as mediators of neuroinflammation

(2014) Archana Gupta et al.   Journal of Neuroinflammation

Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

(2014) Davide Chiasserini et al.   Journal of Proteomics

Thrombospondin 4 deficiency in mouse impairs neuronal migration in the early postnatal and adult brain

(2014) F. Girard et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells

(2014) Elin J Ekström et al.   Molecular Cancer

Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

(2014) Chiara Cossetti et al.   MOLECULAR CELL

Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?

(2014) Arian Aryani et al.   MOLECULAR NEUROBIOLOGY

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis

(2014) Patricia Paez-Gonzalez et al.   NATURE NEUROSCIENCE

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth

(2014) Bruce A. Edgar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Prospective Identification and Purification of Quiescent Adult Neural Stem Cells from Their In Vivo Niche

(2014) Paolo Codega et al.   NEURON

Endothelial NT-3 Delivered by Vasculature and CSF Promotes Quiescence of Subependymal Neural Stem Cells through Nitric Oxide Induction

(2014) Ana C. Delgado et al.   NEURON

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Extracellular-vesicle type of volume transmission and tunnelling-nanotube type of wiring transmission add a new dimension to brain neuro-glial networks

(2014) L. F. Agnati et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation

(2014) D. Frohlich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

(2014) D. M. Pegtel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulation and Function of Adult Neurogenesis: From Genes to Cognition

(2014) James B. Aimone et al.   PHYSIOLOGICAL REVIEWS

Embryonic Cerebrospinal Fluid Nanovesicles Carry Evolutionarily Conserved Molecules and Promote Neural Stem Cell Amplification

(2014) David M. Feliciano et al.   PLoS One

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease

(2014) Branislav R Filipovic   WORLD JOURNAL OF GASTROENTEROLOGY

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

Extracellular Vesicles in Multiple Sclerosis: What are They Telling Us?

(2014) Matías Sáenz-Cuesta et al.   Frontiers in Cellular Neuroscience

GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity

(2014) Stephanie Z. Young et al.   Frontiers in Cellular Neuroscience

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Dll4-containing exosomes induce capillary sprout retraction in a 3D microenvironment

(2014) Soheila Sharghi-Namini et al.   Scientific Reports

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

(2014) Kirsten Ridder et al.   PLOS BIOLOGY

Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity

(2014) Martin Regensburger et al.   NEURAL PLASTICITY

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

(2014) Amanda Sierra et al.   NEURAL PLASTICITY

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

(2014) Francesc Baixauli et al.   Frontiers in Immunology

Plasma Exosomes as Markers of Therapeutic Response in Patients with Acute Myeloid Leukemia

(2014) Chang-Sook Hong et al.   Frontiers in Immunology

Functions and Therapeutic Roles of Exosomes in Cancer

(2014) Jacob A. Tickner et al.   Frontiers in Oncology

Exosomes as a novel way of interneuronal communication

(2013) Mathilde Chivet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The stem cell secretome and its role in brain repair

(2013) Denise Drago et al.   BIOCHIMIE

Exosomes: mediators of communication in eukaryotes

(2013) María A Lopez-Verrilli et al.   BIOLOGICAL RESEARCH

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment

(2013) Mauricio Sandoval et al.   BRAIN RESEARCH

Tuning the cell fate of neurons and glia by microRNAs

(2013) Shan Bian et al.   CURRENT OPINION IN NEUROBIOLOGY

Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

(2013) D. A. Berg et al.   DEVELOPMENT

Classical and unconventional pathways of vesicular release in microglia

(2013) Ilaria Prada et al.   GLIA

Oligodendrocyte-microglia cross-talk in the central nervous system

(2013) Laura Peferoen et al.   IMMUNOLOGY

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes from Retinal Astrocytes Contain Antiangiogenic Components That Inhibit Laser-induced Choroidal Neovascularization

(2013) Amir Reza Hajrasouliha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Disruption of CDH2/N-Cadherin–Based Adherens Junctions Leads to Apoptosis of Ependymal Cells and Denudation of Brain Ventricular Walls

(2013) Cristian Oliver et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

(2013) Anuradha Kalani et al.   MOLECULAR NEUROBIOLOGY

Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

(2013) Ceren Korkut et al.   NEURON

MicroRNAs as Neuronal Fate Determinants

(2013) Malin Åkerblom et al.   NEUROSCIENTIST

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients

(2013) Meredith G. Banigan et al.   PLoS One

Astrocytic Adenosine 5′-Triphosphate Release Regulates the Proliferation of Neural Stem Cells in the Adult Hippocampus

(2013) Xiong Cao et al.   STEM CELLS

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

The brain’s best friend: microglial neurotoxicity revisited

(2013) Sabine Hellwig et al.   Frontiers in Cellular Neuroscience

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

MicroRNAs as Biomarkers for Ischemic Heart Disease

(2013) Lucas N. L. Van Aelst et al.   Journal of Cardiovascular Translational Research

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

(2013) Kyongman An et al.   Molecular Brain

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders

(2013) Heechul Jun et al.   NEURAL PLASTICITY

Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging

(2013) Elias Gebara et al.   Frontiers in Neuroscience

Astrocytes acquire morphological and functional characteristics of ependymal cells following disruption of ependyma in hydrocephalus

(2012) Ruth Roales-Buján et al.   ACTA NEUROPATHOLOGICA

Wnt3a induces exosome secretion from primary cultured rat microglia

(2012) Claudie Hooper et al.   BMC NEUROSCIENCE

The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond

(2012) Mauro W. Zappaterra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Brain pericyte plasticity as a potential drug target in CNS repair

(2012) Simona Lange et al.   DRUG DISCOVERY TODAY

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

(2012) L. Bozoyan et al.   JOURNAL OF NEUROSCIENCE

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

(2012) M. Akerblom et al.   JOURNAL OF NEUROSCIENCE

Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging

(2012) J. Vukovic et al.   JOURNAL OF NEUROSCIENCE

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

(2012) Jonathan M Street et al.   Journal of Translational Medicine

Neurotrophin production in brain pericytes during hypoxia: A role of pericytes for neuroprotection

(2012) Koji Ishitsuka et al.   MICROVASCULAR RESEARCH

Importance of RNA isolation methods for analysis of exosomal RNA: Evaluation of different methods

(2012) Maria Eldh et al.   MOLECULAR IMMUNOLOGY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

Get on the exosome bus with ALIX

(2012) James H. Hurley et al.   NATURE CELL BIOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

(2012) Randolph S Ashton et al.   NATURE NEUROSCIENCE

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Intercellular communication: diverse structures for exchange of genetic information

(2012) Maria Mittelbrunn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Molecular Characterisation of Transport Mechanisms at the Developing Mouse Blood–CSF Interface: A Transcriptome Approach

(2012) Shane A. Liddelow et al.   PLoS One

Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis

(2012) M. V. Gomez-Gaviro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Negatively Regulate Neurogenesis Through the Jagged1-Mediated Notch Pathway

(2012) Ulrika Wilhelmsson et al.   STEM CELLS

Emerging Role of Neuronal Exosomes in the Central Nervous System

(2012) Mathilde Chivet et al.   Frontiers in Physiology

Emerging Roles of Exosomes in Neuron–Glia Communication

(2012) Carsten Frühbeis et al.   Frontiers in Physiology

Microglial microvesicle secretion and intercellular signaling

(2012) Elena Turola   Frontiers in Physiology

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

The changing phenotype of microglia from homeostasis to disease

(2012) Xiao-Guang Luo et al.   Translational Neurodegeneration

New ependymal cells are born postnatally in two discrete regions of the mouse brain and support ventricular enlargement in hydrocephalus

(2011) Luis Federico Bátiz et al.   ACTA NEUROPATHOLOGICA

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

Amphiregulin Exosomes Increase Cancer Cell Invasion

(2011) James N. Higginbotham et al.   CURRENT BIOLOGY

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Neurodegenerative disease and adult neurogenesis

(2011) Beate Winner et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes

(2011) S. Wang et al.   JOURNAL OF NEUROSCIENCE

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

MicroRNA Profiling in Subventricular Zone after Stroke: MiR-124a Regulates Proliferation of Neural Progenitor Cells through Notch Signaling Pathway

(2011) Xian Shuang Liu et al.   PLoS One

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

(2011) Christopher S. Von Bartheld et al.   PROGRESS IN NEUROBIOLOGY

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

(2011) Ruenn Chai Lai et al.   Regenerative Medicine

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Neurogenesis in the aged and neurodegenerative brain

(2010) Adi Shruster et al.   APOPTOSIS

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

(2010) H. Sheldon et al.   BLOOD

Neuroependymal Denudation is in Progress in Full-term Human Foetal Spina Bifida Aperta

(2010) Deborah A. Sival et al.   BRAIN PATHOLOGY

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Adult SVZ Lineage Cells Home to and Leave the Vascular Niche via Differential Responses to SDF1/CXCR4 Signaling

(2010) Erzsebet Kokovay et al.   Cell Stem Cell

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

(2010) Sebastian Lugert et al.   Cell Stem Cell

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Microenvironmental targeting of Wnt/β-catenin signals for hematopoietic stem cell regulation

(2010) Il-Hoan Oh   EXPERT OPINION ON BIOLOGICAL THERAPY

Thrombospondin 1—a key astrocyte-derived neurogenic factor

(2010) Zhenjie Lu et al.   FASEB JOURNAL

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

The ESCRT-Associated Protein Alix Recruits the Ubiquitin Ligase Nedd4-1 To Facilitate HIV-1 Release through the LYPXnL L Domain Motif

(2010) P. Sette et al.   JOURNAL OF VIROLOGY

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

(2010) Gaelle Lachenal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation

(2010) A.I. Pogue et al.   NEUROSCIENCE LETTERS

MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling

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Exosomes: immune properties and potential clinical implementations

(2010) Nathalie Chaput et al.   Seminars in Immunopathology

Circulating endothelial microparticles as a marker of cerebrovascular disease

(2009) Keun-Hwa Jung et al.   ANNALS OF NEUROLOGY

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Enhanced hippocampal neurogenesis in the absence of microglia T cell interaction and microglia activation in the murine running wheel model

(2009) Marta Olah et al.   GLIA

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Disruption of the Neurogenic Niche in the Subventricular Zone of Postnatal Hydrocephalic hyh Mice

(2009) Antonio Jesús Jiménez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Enhanced Adult Neurogenesis and Angiogenesis and Altered Affective Behaviors in Mice Overexpressing Vascular Endothelial Growth Factor 120

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Input-Specific GABAergic Signaling to Newborn Neurons in Adult Dentate Gyrus

(2009) S. J. Markwardt et al.   JOURNAL OF NEUROSCIENCE

Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

(2009) Suresh Mathivanan et al.   MOLECULAR & CELLULAR PROTEOMICS

Repeatability of published microarray gene expression analyses

(2009) John P A Ioannidis et al.   NATURE GENETICS

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

(2009) Marie Carlén et al.   NATURE NEUROSCIENCE

Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

(2009) Celia Andreu-Agulló et al.   NATURE NEUROSCIENCE

New roles for endosomes: from vesicular carriers to multi-purpose platforms

(2009) Gwyn W. Gould et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both?

(2009) Andrew K. Chojnacki et al.   NATURE REVIEWS NEUROSCIENCE

A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination

(2009) Chunnian Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease

(2009) Roberta Ghidoni et al.   NEUROBIOLOGY OF AGING

Immune Influence on Adult Neural Stem Cell Regulation and Function

(2009) Pamela A. Carpentier et al.   NEURON

Activity-Dependent Regulation of Synapses by Retrograde Messengers

(2009) Wade G. Regehr et al.   NEURON

Role and Therapeutic Potential of VEGF in the Nervous System

(2009) Carmen Ruiz de Almodovar et al.   PHYSIOLOGICAL REVIEWS

Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus

(2009) A. Kunze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCγ1 activation for self-renewal of adult neural stem cells

(2009) Dengke K Ma et al.   Molecular Brain

Exosomes – nanovesicles with possible roles in allergic inflammation

(2008) C. Admyre et al.   ALLERGY

The Comorbidity of Diabetes Mellitus and Depression

(2008) Wayne J. Katon   AMERICAN JOURNAL OF MEDICINE

Axon-Glial Signaling and the Glial Support of Axon Function

(2008) Klaus-Armin Nave et al.   Annual Review of Neuroscience

miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells

(2008) Thomas Würdinger et al.   CANCER CELL

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

A Specialized Vascular Niche for Adult Neural Stem Cells

(2008) Masoud Tavazoie et al.   Cell Stem Cell

Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions

(2008) Qin Shen et al.   Cell Stem Cell

Proteomic and immunologic analyses of brain tumor exosomes

(2008) Michael W. Graner et al.   FASEB JOURNAL

Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia

(2008) Russell J. Ferland et al.   HUMAN MOLECULAR GENETICS

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins

(2008) Ulrich Putz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depression and Diabetes: A Potentially Lethal Combination

(2008) Wayne Katon et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Subventricular Zone-Mediated Ependyma Repair in the Adult Mammalian Brain

(2008) J. Luo et al.   JOURNAL OF NEUROSCIENCE

Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?

(2008) A. J. Eisch et al.   JOURNAL OF NEUROSCIENCE

Ciliary Neurotrophic Factor Mediates Dopamine D2 Receptor-Induced CNS Neurogenesis in Adult Mice

(2008) P. Yang et al.   JOURNAL OF NEUROSCIENCE

Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells

(2008) D. Colak et al.   JOURNAL OF NEUROSCIENCE

Proteomic Analysis of Exosomes from Human Neural Stem Cells by Flow Field-Flow Fractionation and Nanoflow Liquid Chromatography−Tandem Mass Spectrometry

(2008) Dukjin Kang et al.   JOURNAL OF PROTEOME RESEARCH

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition

(2008) A. Wu et al.   NEUROSCIENCE

The stumpy gene is required for mammalian ciliogenesis

(2008) T. Town et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

New Interneurons in the Adult Neocortex: Small, Sparse, but Significant?

(2007) Heather A. Cameron et al.   BIOLOGICAL PSYCHIATRY

Brain micro-ecologies: neural stem cell niches in the adult mammalian brain

(2007) P. A Riquelme et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Stem Cell Marker Prominin-1/CD133 on Membrane Particles in Human Cerebrospinal Fluid Offers Novel Approaches for Studying Central Nervous System Disease

(2007) Hagen B. Huttner et al.   STEM CELLS