Postnatal Loss of Hap1 Reduces Hippocampal Neurogenesis and Causes Adult Depressive-Like Behavior in Mice

The Genetics of Major Depression

(2014) Jonathan Flint et al.   NEURON

Prolactin administration during early postnatal life decreases hippocampal and olfactory bulb neurogenesis and results in depressive-like behavior in adulthood

(2013) Naima Lajud et al.   HORMONES AND BEHAVIOR

Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting

(2013) Jianxing Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites

(2013) G. Liot et al.   JOURNAL OF NEUROSCIENCE

Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus

(2013) Juan Song et al.   NATURE NEUROSCIENCE

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

BDNF Promotes Differentiation and Maturation of Adult-born Neurons through GABAergic Transmission

(2012) E. G. Waterhouse et al.   JOURNAL OF NEUROSCIENCE

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Characterization of the “sporadically lurking HAP1-immunoreactive (SLH) cells” in the hippocampus, with special reference to the expression of steroid receptors, GABA, and progenitor cell markers

(2012) Md.N. Islam et al.   NEUROSCIENCE

The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse

(2012) J. P. R. Jacobsen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Depression and Hippocampal Neurogenesis: A Road to Remission?

(2012) A. J. Eisch et al.   SCIENCE

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing

(2011) Miao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

(2011) David J Kupfer et al.   LANCET

The Interesting Interplay Between Interneurons and Adult Hippocampal Neurogenesis

(2011) Irene Masiulis et al.   MOLECULAR NEUROBIOLOGY

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood

(2011) Naima Lajud et al.   PSYCHONEUROENDOCRINOLOGY

The neurobiology of anhedonia and other reward-related deficits

(2011) Andre Der-Avakian et al.   TRENDS IN NEUROSCIENCES

Huntingtin-associated Protein-1 Deficiency in Orexin-producing Neurons Impairs Neuronal Process Extension and Leads to Abnormal Behavior in Mice

(2010) Yung-Feng Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

(2010) Alison E. Twelvetrees et al.   NEURON

Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype

(2010) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

(2010) Raúl Pardo et al.   Molecular Brain

Effects of Acute and Chronic Stressors and CRF in Rat and Mouse Tests for Depression

(2009) Adrian J. Dunn et al.   Annals of the New York Academy of Sciences

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

Huntingtin-associated Protein-1 Interacts with Pro-brain-derived Neurotrophic Factor and Mediates Its Transport and Release

(2009) Linda Lin-yan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antidepressants increase neural progenitor cells in the human hippocampus

(2009) Maura Boldrini et al.   NEUROPSYCHOPHARMACOLOGY

Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response

(2009) Robert J. Schloesser et al.   NEUROREPORT

A reduced number of hippocampal granule cells does not associate with an anhedonia-like phenotype in a rat chronic mild stress model of depression

(2009) Magdalena Niepsuj Jayatissa et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   BIOLOGICAL PSYCHIATRY

Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice

(2008) Guoqing Sheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells

(2008) J.-W. Wang et al.   JOURNAL OF NEUROSCIENCE

Major Depressive Disorder

(2008) R.H. Belmaker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The HPA axis in major depression: classical theories and new developments

(2008) Carmine M. Pariante et al.   TRENDS IN NEUROSCIENCES

Decreased postnatal neurogenesis in the hippocampus combined with stress experience during adolescence is accompanied by an enhanced incidence of behavioral pathologies in adult mice

(2008) Fumihiko Hayashi et al.   Molecular Brain