Exosome Biogenesis, Regulation, and Function in Viral Infection

Mechanisms of RNA loading into exosomes

(2015) Teresa Janas et al.   FEBS LETTERS

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate

(2015) Pehuén Pereyra Gerber et al.   JOURNAL OF CELL BIOLOGY

Exosomal Communication Goes Viral

(2015) David G. Meckes   JOURNAL OF VIROLOGY

Modulation of DNA Damage and Repair Pathways by Human Tumour Viruses

(2015) Robert Hollingworth et al.   Viruses-Basel

Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells

(2015) Anja Honegger et al.   PLoS Pathogens

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Exosomes as divine messengers: are they the Hermes of modern molecular oncology?

(2014) C Braicu et al.   CELL DEATH AND DIFFERENTIATION

Exosomes and other extracellular vesicles in host-pathogen interactions

(2014) J. S. Schorey et al.   EMBO REPORTS

The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release

(2014) C. A. Escudero et al.   JOURNAL OF CELL SCIENCE

Exosomes Derived from Burkitt's Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells

(2014) C. Gutzeit et al.   JOURNAL OF IMMUNOLOGY

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Transfer of Intracellular HIV Nef to Endothelium Causes Endothelial Dysfunction

(2014) Ting Wang et al.   PLoS One

Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs

(2014) Maria Kalamvoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNAs are biomarkers of oncogenic human papillomavirus infections

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endosomal vesicles as vehicles for viral genomes

(2014) Adel M. Nour et al.   TRENDS IN CELL BIOLOGY

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Exosomes

(2013) Huang-Ge Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

(2013) Alicia Llorente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

(2013) Arsen O Batagov et al.   Biology Direct

Exosomes released in vitro from Epstein–Barr virus (EBV)-infected cells contain EBV-encoded latent phase mRNAs

(2013) Andrea Canitano et al.   CANCER LETTERS

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Arf GTPase regulation through cascade mechanisms and positive feedback loops

(2013) Danièle Stalder et al.   FEBS LETTERS

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

(2013) Aarthi Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RabGEFs are a major determinant for specific Rab membrane targeting

(2013) Julia Blümer et al.   JOURNAL OF CELL BIOLOGY

Rab GTPases and membrane identity: Causal or inconsequential?

(2013) Francis A. Barr   JOURNAL OF CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells

(2013) M. A. Ansari et al.   JOURNAL OF VIROLOGY

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Human Papillomaviruses Modulate MicroRNA 145 Expression To Directly Control Genome Amplification

(2013) V. Gunasekharan et al.   JOURNAL OF VIROLOGY

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

(2013) Anuradha Kalani et al.   MOLECULAR NEUROBIOLOGY

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

(2013) Zongdi Feng et al.   NATURE

Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells

(2013) V. Ramakrishnaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of B-cell exosome proteins by gamma herpesvirus infection

(2013) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics, transcriptomics and lipidomics of exosomes and ectosomes

(2013) Dong-Sic Choi et al.   PROTEOMICS

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

How to get out: ssRNA enveloped viruses and membrane fission

(2013) Winfried Weissenhorn et al.   Current Opinion in Virology

Virus-Encoded microRNAs: An Overview and a Look to the Future

(2013) Rodney P. Kincaid et al.   PLoS Pathogens

Viral Membrane Fusion and Nucleocapsid Delivery into the Cytoplasm are Distinct Events in Some Flaviviruses

(2013) Adel M. Nour et al.   PLoS Pathogens

Rab11 proteins in health and disease

(2012) Eoin E. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Role of the small GTPase Rab27a during Herpes simplex virus infection of oligodendrocytic cells

(2012) Raquel Bello-Morales et al.   BMC MICROBIOLOGY

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

(2012) Marlène Dreux et al.   Cell Host & Microbe

BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor

(2012) Andreas Gerondopoulos et al.   CURRENT BIOLOGY

TGF- 1-Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

(2012) F. T. Borges et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Coordination between RAB GTPase and phosphoinositide regulation and functions

(2012) Steve Jean et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

(2012) Karen Beckett et al.   TRAFFIC

Extracellular miRNAs: the mystery of their origin and function

(2012) Andrey Turchinovich et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential expression of cellular microRNAs in HPV 11, -16, and -45 transfected cells

(2011) Anita Dreher et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of a Poliovirus Neutralization Test with Poliovirus Pseudovirus for Measurement of Neutralizing Antibody Titer in Human Serum

(2011) Minetaro Arita et al.   Clinical and Vaccine Immunology

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication

(2011) K. L. Berger et al.   JOURNAL OF VIROLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

Replication-Competent Influenza A Virus That Encodes a Split-Green Fluorescent Protein-Tagged PB2 Polymerase Subunit Allows Live-Cell Imaging of the Virus Life Cycle

(2011) S. V. Avilov et al.   JOURNAL OF VIROLOGY

RAB11A Is Essential for Transport of the Influenza Virus Genome to the Plasma Membrane

(2011) A. J. Eisfeld et al.   JOURNAL OF VIROLOGY

A Rab11- and Microtubule-Dependent Mechanism for Cytoplasmic Transport of Influenza A Virus Viral RNA

(2011) M. J. Amorim et al.   JOURNAL OF VIROLOGY

Apical Transport of Influenza A Virus Ribonucleoprotein Requires Rab11-positive Recycling Endosome

(2011) Fumitaka Momose et al.   PLoS One

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway

(2011) Keiichi Tamai et al.   VIROLOGY

The ESCRT complexes

(2010) James H. Hurley   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Rab GEFs and GAPs

(2010) Francis Barr et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

The Rab11 Pathway Is Required for Influenza A Virus Budding and Filament Formation

(2010) E. A. Bruce et al.   JOURNAL OF VIROLOGY

Membrane budding and scission by the ESCRT machinery: it's all in the neck

(2010) James H. Hurley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trafficking of Sendai Virus Nucleocapsids Is Mediated by Intracellular Vesicles

(2010) Raychel Chambers et al.   PLoS One

Rab27a Is Required for Human Cytomegalovirus Assembly

(2010) Alberto Fraile-Ramos et al.   PLoS One

Human tumor virus utilizes exosomes for intercellular communication

(2010) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes: immune properties and potential clinical implementations

(2010) Nathalie Chaput et al.   Seminars in Immunopathology

The dynamic Rab11-FIPs

(2009) Conor P. Horgan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

The Herpes Simplex Virus-1 Encoded Glycoprotein B Diverts HLA-DR into the Exosome Pathway

(2009) Sebastian Temme et al.   JOURNAL OF IMMUNOLOGY

Herpes Simplex Virus Type 1 Production Requires a Functional ESCRT-III Complex but Is Independent of TSG101 and ALIX Expression

(2009) T. Pawliczek et al.   JOURNAL OF VIROLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian phosphoinositide kinases and phosphatases

(2009) Takehiko Sasaki et al.   PROGRESS IN LIPID RESEARCH

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling

(2008) E. Schonteich et al.   JOURNAL OF CELL SCIENCE

Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2

(2008) T. J. Utley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Human Herpesvirus-6 Induces MVB Formation, and Virus Egress Occurs by an Exosomal Release Pathway

(2008) Yasuko Mori et al.   TRAFFIC

Roles for the recycling endosome, Rab8, and Rab11 in hantavirus release from epithelial cells

(2008) Regina K. Rowe et al.   VIROLOGY