An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

HIV Protein Sequence Hotspots for Crosstalk with Host Hub Proteins

(2011) Mahdi Sarmady et al.   PLoS One

HIV-1 Nef Induces Proinflammatory State in Macrophages through Its Acidic Cluster Domain: Involvement of TNF Alpha Receptor Associated Factor 2

(2011) Giorgio Mangino et al.   PLoS One

Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly

(2011) Florian A. Horenkamp et al.   TRAFFIC

Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

(2010) Syed A. Ali et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

(2010) M. E. Harbour et al.   JOURNAL OF CELL SCIENCE

High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

(2010) T. C. Friedrich et al.   JOURNAL OF VIROLOGY

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action

(2010) Jimmy D. Dikeakos et al.   MOLECULAR BIOLOGY OF THE CELL

Achieving reliability and high accuracy in automated protein docking: Cluspro, PIPER, SDU, and stability analysis in CAPRI rounds 13-19

(2010) Dima Kozakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis

(2009) Robert T. Youker et al.   BIOCHEMICAL JOURNAL

HIV-1 Nef Dimerization Is Required for Nef-Mediated Receptor Downregulation and Viral Replication

(2009) Jerrod A. Poe et al.   JOURNAL OF MOLECULAR BIOLOGY

PACS-1 Mediates Phosphorylation-Dependent Ciliary Trafficking of the Cyclic-Nucleotide-Gated Channel in Olfactory Sensory Neurons

(2009) P. M. Jenkins et al.   JOURNAL OF NEUROSCIENCE

Akt and 14-3-3 Control a PACS-2 Homeostatic Switch that Integrates Membrane Traffic with TRAIL-Induced Apoptosis

(2009) Joseph E. Aslan et al.   MOLECULAR CELL

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence

(2009) Holger Gerlach et al.   Nature Chemical Biology

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

(2009) Weifeng Xu et al.   NATURE IMMUNOLOGY

An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat Complex

(2009) Rajendra Kumar Singh et al.   PLoS One

Transferrin-Directed Internalization and Cycling of Transferrin Receptor 2

(2009) Juxing Chen et al.   TRAFFIC

Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells

(2008) Tom K. Kerppola   Annual Review of Biophysics

HIV-1 Nef Binds PACS-2 to Assemble a Multikinase Cascade That Triggers Major Histocompatibility Complex Class I (MHC-I) Down-regulation

(2008) Katelyn M. Atkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking

(2008) K. Haberg et al.   JOURNAL OF CELL SCIENCE

The Subcellular Distribution of Calnexin Is Mediated by PACS-2

(2008) Nathan Myhill et al.   MOLECULAR BIOLOGY OF THE CELL

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens