Perfluorooctane Sulfonate Induces Autophagy-Dependent Apoptosis through Spinster 1-Mediated lysosomal-Mitochondrial Axis and Impaired Mitophagy

Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish

(2016) Jiangfei Cheng et al.   AQUATIC TOXICOLOGY

Hepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS)

(2016) Hongyan Dong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?

(2015) Huali Wu et al.   ENVIRONMENT INTERNATIONAL

Associations of perfluorinated chemical serum concentrations and biomarkers of liver function and uric acid in the US population (NHANES), 2007–2010

(2015) Jessie A. Gleason et al.   ENVIRONMENTAL RESEARCH

Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system

(2015) Yoshiyuki Ikeda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The effects of perfluorinated chemicals on adipocyte differentiation in vitro

(2015) Andrew M. Watkins et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Citreoviridin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis in Human Liver HepG2 Cells

(2015) Yuexia Wang et al.   Toxins

Characterisation of perfluorooctane sulfonate (PFOS) in a terrestrial ecosystem near a fluorochemical plant in Flanders, Belgium

(2014) Wendy D’Hollander et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Perfluorooctane sulfonate blocked autophagy flux and induced lysosome membrane permeabilization in HepG2 cells

(2014) Xiao-Feng Yao et al.   FOOD AND CHEMICAL TOXICOLOGY

Autophagic Cell Death and Cancer

(2014) Shigeomi Shimizu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)

(2014) Kamini Singh et al.   Molecular Cancer

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

(2014) Tomoyuki Sasaki et al.   PLoS Genetics

Myricetin Induces Apoptosis in HepG2 Cells Through Akt/p70S6K/Bad Signaling and Mitochondrial Apoptotic Pathway

(2013) Xiao-Hong Zhang et al.   Anti-Cancer Agents in Medicinal Chemistry

Ardipusilloside I induces apoptosis by regulating Bcl-2 family proteins in human mucoepidermoid carcinoma Mc3 cells

(2013) Xiao-Fang Xu et al.   BMC Complementary and Alternative Medicine

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

(2013) G C Higgins et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

(2013) Gilles Gouspillou et al.   FASEB JOURNAL

Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation

(2013) Fei Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Consumption of Seafood, Serum Liver Enzymes, and Blood Levels of PFOS and PFOA in the Japanese Population

(2013) Miwa Yamaguchi et al.   JOURNAL OF OCCUPATIONAL HEALTH

Impairment of Autophagic Flux Promotes Glucose Reperfusion-Induced Neuro2A Cell Death after Glucose Deprivation

(2013) Bong Geom Jang et al.   PLoS One

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

(2013) W Wang et al.   Cell Death & Disease

COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production

(2013) Yuanyuan Zhao et al.   PLoS Pathogens

DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4+ T Cells Infected with HIV

(2013) Mireille Laforge et al.   PLoS Pathogens

ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage

(2012) David H. Kessel et al.   Autophagy

Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

(2012) P Gonzalez et al.   CELL DEATH AND DIFFERENTIATION

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Concentrations of perfluoroalkyl compounds in maternal and umbilical cord sera and birth outcomes in Korea

(2012) Youn Ju Lee et al.   CHEMOSPHERE

Serum Perfluorooctanoate (PFOA) and Perfluorooctane Sulfonate (PFOS) Concentrations and Liver Function Biomarkers in a Population with Elevated PFOA Exposure

(2012) Valentina Gallo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dung-shen (Codonopsis pilosula) attenuated the cardiac-impaired insulin-like growth factor II receptor pathway on myocardial cells

(2012) Kun-Hsi Tsai et al.   FOOD CHEMISTRY

Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases

(2012) Raquel de Pablo-Latorre et al.   HUMAN MOLECULAR GENETICS

Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

(2012) Ying-Hua Zhang et al.   Journal of Immunotoxicology

Perfluorooctane sulfonate induces apoptosis of cerebellar granule cells via a ROS-dependent protein kinase C signaling pathway

(2012) Hyun-Gyo Lee et al.   NEUROTOXICOLOGY

6-Gingerol Induces Apoptosis through Lysosomal-Mitochondrial Axis in Human Hepatoma G2 Cells

(2012) Guang Yang et al.   PHYTOTHERAPY RESEARCH

Mesenchymal Stem Cells Secrete Multiple Cytokines That Promote Angiogenesis and Have Contrasting Effects on Chemotaxis and Apoptosis

(2012) Robert A. Boomsma et al.   PLoS One

Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR

(2012) Clifford R. Elcombe et al.   TOXICOLOGY

Induction of p53-mediated apoptosis in splenocytes and thymocytes of C57BL/6 mice exposed to perfluorooctane sulfonate (PFOS)

(2012) Guang-Hui Dong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autophagy and Neuronal Cell Death in Neurological Disorders

(2012) R. A. Nixon et al.   Cold Spring Harbor Perspectives in Biology

Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model

(2012) H-Y Lopilly Park et al.   Cell Death & Disease

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission

(2011) Thomas Landes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells

(2011) Qinwen Wang et al.   CANCER LETTERS

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease

(2011) Madeleine Diedrich et al.   Proteome Science

Tissue distribution of 35S-labelled perfluorooctane sulfonate in adult mice after oral exposure to a low environmentally relevant dose or a high experimental dose

(2011) Jasna Bogdanska et al.   TOXICOLOGY

Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion

(2010) Nirmala Hariharan et al.   ANTIOXIDANTS & REDOX SIGNALING

Phenotypic interactions of spinster with the genes encoding proteins for cell death control in Drosophila melanogaster

(2010) Akira Sakurai et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994–2008 and Vietnam in 2007–2008

(2010) Kouji H. Harada et al.   CHEMOSPHERE

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

Cell Death Mechanisms and Their Implications in Toxicology

(2010) Sten Orrenius et al.   TOXICOLOGICAL SCIENCES

Effects of perfluorooctanoate and perfluorooctane sulfonate exposure on hepatoma Hep G2 cells

(2009) Xiao-Zhong Hu et al.   ARCHIVES OF TOXICOLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Lysosome-targeted stress reveals increased stability of lipofuscin-containing lysosomes

(2008) Yuri Stroikin et al.   AGE

Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth

(2008) Noriaki Washino et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Perfluorinated compounds – Exposure assessment for the general population in western countries

(2008) Hermann Fromme et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

Giant mitochondria do not fuse and exchange their contents with normal mitochondria

(2007) Marian Navratil et al.   EXPERIMENTAL CELL RESEARCH