Article
Environmental Sciences
Qingwen Yang, Yudong Fang, Chuanshi Zhang, Xuesong Liu, Youhua Wu, Yi Zhang, Junjie Yang, Kang Yong
Summary: Excess exposure to zinc can cause damage to host cells, including dysfunction of lysosomes and mitochondria, leading to apoptosis. The lysosomal-mitochondrial axis plays a crucial role in zinc-induced cytotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, Research & Experimental
Mengliang Luo, Zexin Su, Haotian Gao, Jianye Tan, Rongdong Liao, Jiancheng Yang, Lijun Lin
Summary: Cirsiliol inhibits the growth of osteosarcoma cells and induces cell apoptosis by reducing AKT phosphorylation and promoting FOXO1 expression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Arlet Hernandez, Manoj Sonavane, Kelly R. Smith, Jensyn Seiger, Marie E. Migaud, Natalie R. Gassman
Summary: Dihydroxyacetone (DHA), the active ingredient in sunless tanning products and a byproduct of e-cigarette combustion, has various effects on cells including cell cycle arrest, reactive oxygen species generation, and mitochondrial dysfunction. In this study, the toxic effects of millimolar doses of DHA on HepG3 cells were investigated, revealing suppression of glycolysis and oxidative phosphorylation pathways and altered mTOR signaling. Increased mitochondrial reactive oxygen species and mitochondrial-specific injury led to cell cycle arrest and cell death through a non-classical apoptotic mechanism.
Article
Food Science & Technology
Huan Liu, Linjing Xu, Lizi Zhou, Wenna Han, Zhongyi Li, Chunhong Liu
Summary: In this study, HepG2 cells were treated with different concentrations of Dibutyl phthalate (DBP) to investigate its mitochondrial toxicity. DBP caused mitochondrial damage, autophagy, apoptosis, and necroptosis in the cells. Transcriptomics analysis identified the MAPK and PI3K pathways as significant factors in the cytotoxic changes induced by DBP. Treatment with N-Acetyl-L-cysteine, SIRT1 activator, ERK inhibitor, p38 inhibitor, and ERK siRNA reversed the changes induced by DBP, while PI3K and Nrf2 inhibitors exacerbated the changes. In addition, the autophagy inhibitor 3-MA alleviated the increase in DBP-induced necroptosis proteins.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Yan Zhang, Ning He, Xuejian Zhou, Feifan Wang, Hairong Cai, Shih Han Huang, Xianwu Chen, Zhenghui Hu, Xiaodong Jin
Summary: Betulinic acid (BA) exhibits antitumor effects against human bladder cancer cells by triggering autophagy and apoptosis. The effects can be attenuated by inhibiting ROS production, inhibiting autophagy, or silencing ATG7. BA activates autophagy via the AMPK/mTOR/ULK1 pathway, with potential downregulation of Bmi-1 as a mechanism for autophagy-dependent apoptosis.
Article
Food Science & Technology
Pengcheng Pang, Xing Zhang, Jingping Yuan, Hong Yan, Dandan Yan
Summary: Acrylamide (ACR), a neurotoxicant found in starchy foods, can inhibit autophagy and induce apoptosis. This study aimed to investigate the role of Transcription Factor EB (TFEB) in ACR-induced lysosomal dysfunction and cellular apoptosis in Neuro-2a cells. The results showed that ACR exposure inhibited autophagic flux and caused lysosomal dysfunction and increased apoptosis. TFEB overexpression alleviated lysosomal dysfunction, while TFEB knockdown exacerbated it. These findings provide new insights into the mechanism of ACR neurotoxicity and potential targets for prevention and treatment.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wojciech Trybus, Teodora Krol, Ewa Trybus
Summary: This study evaluated the impact of rhein, an anthraquinone compound found in Chinese medicine, on the lysosomal compartment and its indirect influence on cell apoptosis. The results showed that high concentrations of rhein caused oxidative stress and changes in lysosomal membrane permeability, leading to cell apoptosis. In addition, the use of an autophagy inhibitor, chloroquine, enhanced the cytotoxicity of rhein.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Immunology
Chunxiao Mou, Yuxi Wang, Shuonan Pan, Kaichuang Shi, Zhenhai Chen
Summary: This research investigated the cell apoptosis induced by Porcine sapelovirus (PSV) infection and its underlying mechanisms. The results showed typical features of apoptosis, such as nuclear condensation and fragmentation, after infection. Cell apoptosis was confirmed by analyzing apoptotic rates, caspase activation, and PARP1 cleavage. The study found that 2A protein encoded by PSV was a crucial factor in inducing the mitochondrial apoptotic pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu
Summary: Cadmium-induced liver toxicity is associated with ferroptosis, which is involved in oxidative stress, autophagy, and endoplasmic reticulum stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Veterinary Sciences
Jiaxin Chen, Yalin Su, Renzhao Lin, Fei Lin, Peng Shang, Riaz Hussain, Dayou Shi
Summary: The study demonstrated that DQ has adverse effects on the liver of ducks, primarily affecting apoptosis and autophagy mechanisms. The research on pro-apoptotic and autophagy factors indicated that DQ induces both processes in duck cells, and the exposed organisms may resist the toxic effects by increasing anti-apoptotic factors.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Plant Sciences
Ying Chen, Hisao-Hsien Wang, Hsin-Han Chang, Yun-Hsuan Huang, Jeffrey R. Wang, Chih-Ying Changchien, Sheng-Tang Wu
Summary: The study demonstrated the anticancer effects of E-isomer GS in human bladder cancer cell lines of different grades through cell cycle regulation, apoptosis, autophagy, and other mechanisms. Additionally, GS reduced cell migration ability and inhibited tumor growth.
Article
Cell Biology
Yongqi Zhen, Zhaoxin Yuan, Jiahui Zhang, Yao Chen, Yuning Fu, Yi Liu, Leilei Fu, Lan Zhang, Xian-Li Zhou
Summary: This study found that flubendazole could inhibit the proliferation and migration of breast cancer cells by impairing mitochondrial function. Moreover, excessive DRP1-mediated mitophagy plays a critical role in the anticancer effects of EVA1A.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Jiangnan Yi, Jianzhao Liao, Tian Bai, Bole Wang, Chamba Yangzom, Zulfiqar Ahmed, Khalid Mehmood, Rao Zahid Abbas, Ying Li, Zhaoxin Tang, Hui Zhang
Summary: Battery waste has toxic effects on kidney function, leading to changes in mitochondria division-related genes and proteins, increased expression of autophagy and apoptosis-related genes and proteins, and decreased expression of certain genes and proteins.
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Jung Park, Sun-Young Yoon, Jung-Nam Park, Jae-Hee Suh, Hye-Seon Choi
Summary: This study found that doxorubicin-induced bone loss is partly caused by the upregulation of autophagy in osteoclasts (OCs). Doxorubicin induces autophagy in OCs through the mitochondrial reactive oxygen species (mROS)/transient receptor potential mucolipin 1 (TRPML1)/transcription factor EB (TFEB) axis pathway. The results show that doxorubicin-induced autophagy increases the area of OCs and bone resorption activity, while decreasing the number of OCs through apoptosis, resulting in bone loss. The autophagy inhibitor 3-methyladenine (3-MA) reverses the effects of doxorubicin by reducing the area of OCs, thus reversing doxorubicin-induced bone loss.
Article
Engineering, Environmental
Sen Wei, Tianming Qiu, Xiaofeng Yao, Ningning Wang, Liping Jiang, Xue Jia, Ye Tao, Zhidong Wang, Pei Pei, Jingyuan Zhang, Yuhan Zhu, Guang Yang, Xiaofang Liu, Shuang Liu, Xiance Sun
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Cell Biology
Ye Tao, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Ningning Wang, Jintong Jiang, Xue Jia, Sen Wei, Jingyuan Zhang, Yuhan Zhu, Wenyue Tian, Guang Yang, Xiaofang Liu, Shuang Liu, Yang Ding, Xiance Sun
Summary: Liver fibrosis is a significant global health issue characterized by HSCs activation and collagen deposition, which can be induced by arsenic exposure leading to ROS generation and IRE1α/NOX4 pathway activation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Toxicology
Xuan Wang, Zhiguo Li, Zeyun Gao, Qiujuan Li, Liping Jiang, Chengyan Geng, Xiaofeng Yao, Xiaoxia Shi, Yong Liu, Jun Cao
TOXICOLOGY IN VITRO
(2020)
Article
Environmental Sciences
Sen Wei, Tianming Qiu, Ningning Wang, Xiaofeng Yao, Liping Jiang, Xue Jia, Ye Tao, Jingyuan Zhang, Yuhan Zhu, Guang Yang, Xiaofang Liu, Shuang Liu, Xiance Sun
ENVIRONMENTAL RESEARCH
(2020)
Review
Cell Biology
Dan Liu, Zhanchen Dong, Jinling Wang, Ye Tao, Xiance Sun, Xiaofeng Yao
Article
Food Science & Technology
Qian Chu, Shaopeng Wang, Liping Jiang, Yuhang Jiao, Xiance Sun, Jing Li, Ling Yang, Yunfeng Hou, Ningning Wang, Xiaofeng Yao, Xiaofang Liu, Cong Zhang, Guang Yang
Summary: The study characterized the role of the autophagic-inflammasomal pathway in pyroptosis induced by Patulin (PAT). It was found that PAT induced pyroptosis through activation of the NLRP3 inflammasome and release of cathepsin B, providing new mechanistic insights into PAT-induced hepatotoxicity. These findings suggest that PAT-induced pyroptosis may be mediated through the autophagy-cathepsin B-inflammasomal pathway in the liver.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Endocrinology & Metabolism
Tong Chen, Dan Liu, Xiaofeng Yao
Summary: Gestational diabetes mellitus is a common and severe complication of pregnancy, with treatment focusing on controlling maternal blood glucose. Current methods are unable to completely avoid adverse pregnancy outcomes, highlighting the urgent need for prevention and treatment to improve pregnancy outcomes.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Agriculture, Multidisciplinary
Xueyan Wu, Jing Li, Shaopeng Wang, Liping Jiang, Xiance Sun, Xiaofang Liu, Xiaofeng Yao, Cong Zhang, Ningning Wang, Guang Yang
Summary: Exposure to PM2.5 can induce kidney inflammation, but supplementation of 2-undecanone can alleviate this inflammatory injury by potentially involving mitophagy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Jingyuan Zhang, Tianming Qiu, Liping Jiang, Ningning Wang, Yuhan Zhu, Rushan Yan, Shengyu Wang, Jie Bai, Xiaoxia Shi, Guang Yang, Xiaofang Liu, Xiaofeng Yao, Xiance Sun
Summary: Arsenic exposure causes hepatic insulin resistance by activating NLRP3 inflammasome and inhibiting glycolysis pathway. NLRP3 inflammasome binds to PKLR, leading to the development of insulin resistance in the liver.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Zhanchen Dong, Tianming Qiu, Jingyuan Zhang, Shanshan Sha, Xiuyan Han, Jian Kang, Xiaoxia Shi, Xiance Sun, Liping Jiang, Guang Yang, Xiaofeng Yao, Yufang Ma
Summary: The study revealed the association and mechanism of action of SPNS1 in the interplay between autophagy and LMP induced by PFOS, emphasizing the importance of SPNS1-tyrosinated alpha-tubulin interaction. Stable overexpression of SPNS1 can accelerate lysosomal acidification, thereby worsening PFOS-induced LMP.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Cell Biology
Zhanchen Dong, Xiaofeng Yao
Summary: The occurrence and development of IR are primarily caused by excessive energy intake and reduced energy consumption, with the liver playing an important role in systemic IR. Decreased capacity of oxidative metabolism and mitochondrial dysfunction are being blamed as the direct reasons for the development of IR.
Article
Biochemistry & Molecular Biology
Zhanchen Dong, Xuejun Yang, Tianming Qiu, Yu An, Genghua Zhang, Qiujuan Li, Liping Jiang, Guang Yang, Jun Cao, Xiance Sun, Xiaofang Liu, Dan Liu, Xiaofeng Yao
Summary: This study found that exosomes derived from CIT-treated hepatocytes induce mitochondrial calcium accumulation and activate HSC through miR-181a-2-3p-mediated inhibition of MICU1 expression, shedding new light on the mechanism of liver fibrosis and CIT hepatotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Zhanchen Dong, Jianyu Wang, Tianming Qiu, Jialu Wu, Yu An, Xiaoxia Shi, Xiance Sun, Liping Jiang, Xiaofang Liu, Guang Yang, Jun Cao, Xiaofeng Yao
Summary: This study found that PFOS causes insulin resistance by promoting autophagy and mitochondrial calcium accumulation. The study also identified detyrosinated alpha-tubulin as a key component connecting autophagy and mitochondrial calcium response.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Jianyu Wang, Jinling Wang, Tianming Qiu, Jialu Wu, Xiance Sun, Liping Jiang, Xiaofang Liu, Guang Yang, Jun Cao, Xiaofeng Yao
Summary: This study found that perfluorooctane sulfonate (PFOS) can induce mitochondrial iron accumulation in the liver, leading to insulin resistance. The inhibition of mitochondrial iron can relieve PFOS-induced insulin resistance. The translocation of transferrin receptor 2 (TFR2) and ATP synthase beta subunit (ATP5B) from the plasma membrane to mitochondria plays a crucial role in PFOS-induced mitochondrial iron overload and insulin resistance.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Xue Jia, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Ningning Wang, Sen Wei, Ye Tao, Pei Pei, Zhidong Wang, Jingyuan Zhang, Yuhan Zhu, Guang Yang, Xiaofang Liu, Shuang Liu, Xiance Sun
JOURNAL OF HAZARDOUS MATERIALS
(2020)