Article
Agriculture, Multidisciplinary
Keer Ma, Zhigao Wang, Xingrong Ju, Jiankang Huang, Rong He
Summary: In this study, it was found that rapeseed peptide can inhibit the proliferation of HepG2 cells and induce cell apoptosis through the mitochondrial pathway. The rapeseed peptide activates the P53 signaling pathway and inhibits MDM2, a negative regulator of P53, promoting the activation of P53.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Medicinal
Shiting Hu, Yonghui Zhang, Baowen Dang, Yuejing Wang, Guodong Zheng, Tao Zhang, Hongli An
Summary: Immunologic contact urticaria (ICU) is a type I hypersensitivity reaction mediated by allergen-specific immunoglobulin E (sIgE). Myricetin (Myr), a flavonoid, has anti-inflammatory properties. Myr treatment alleviated ICU symptoms, reduced IgE levels and inflammatory markers in mice. Myr inhibited mast cell activation and reduced calcium influx and degranulation in human mast cells. Myr exerted its effects through the PI3K/Akt/NF-kappa B signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Article
Oncology
Qi Li, Qi Tan, Yangfei Ma, Zehui Gu, Suxian Chen
Summary: This study assessed the effects of myricetin on non-tumor cells and ovarian cancer cells, and found that myricetin can suppress the proliferation, migration, and invasion of ovarian cancer cells by activating the p38/Sapla signaling pathway to reduce oxidative stress and ROS levels.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Zeeshan Javed, Khushbukhat Khan, Jesus Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Qamar Raza, Haleema Sadia, Shahid Raza, Munir Bhinder, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Summary: Extensive research in molecular oncology has narrowed down the gaps between the complex nature of cancer and therapeutic approaches. However, therapy resistance and adverse side effects remain major challenges. Myricetin, a natural flavonoid, has gained attention due to its anti-cancer, anti-oxidant, and anti-inflammatory properties. Limited data is available regarding myricetin-based nano-delivery platforms for cancer treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Plant Sciences
Gil-Sun Park, Bokyung Park, Mi-Young Lee
Summary: The incidence of skin cancer, particularly melanoma, a highly malignant tumor, has been increasing. Plant-derived berberine has been found to induce cell death in melanoma cells through a mechanism involving inhibition of apoptosis and promotion of autophagy. Further investigation revealed that berberine induces autophagic cell death by inactivating the Akt/mTOR signaling pathway.
Article
Oncology
Xian Liu, Yanru Zhang, PengSheng Zheng, Nan Cui
Summary: Msi1 regulates cervical cancer cell apoptosis by inhibiting PTEN and activating AKT signaling, leading to the downregulation of BAK.
Article
Oncology
Yutao Guan, Qianlong Wu, Miaomiao Li, Danyang Chen, Jingyao Su, Liandong Zuo, Bing Zhu, Yinghua Li
Summary: This study evaluated the cytotoxic and anti-cancer mechanisms of Epigallocatechin-3-gallate (EGCG) in HepG2 cells. The results showed that EGCG induced apoptosis in HepG2 cells by activating the AKT, JNK, and p53 signaling pathways. Therefore, EGCG may be a suitable candidate for cancer chemotherapy.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Oncology
Huynh Diem Thi Ngoc, Yujin Jin, Chang-Seon Myung, Kyung-Sun Heo
Summary: Breast cancer is the most common cause of cancer-related deaths among women globally. Ginsenoside Rh1 exhibits potential anticancer effects on breast cancer cells by inducing cell cycle arrest, apoptosis, and autophagy via inhibition of the ROS-mediated PI3K/Akt pathway.
Article
Oncology
Mengmeng Wang, Mingjun Gao, Yong Chen, Jun Wu, Xiaolin Wang, Yusheng Shu
Summary: This study found that PLCD3 is highly expressed in ESCC tissues and cell lines, and its expression is correlated with pathological stage and lymphatic metastasis. PLCD3 knockdown inhibits cell proliferation, migration, and invasion, promotes apoptosis, and arrests the cell cycle in the G1 phase. PLCD3 overexpression, on the other hand, promotes cell proliferation, migration, and invasion. Xenograft models also suggest that PLCD3 promotes tumorigenesis in ESCC. Finally, overexpression of PLCD3 activates the PI3K/AKT/P21 signaling pathway.
Article
Pathology
Zhaohui Liu, Zheng Hu, Xingdong Cai, Shengming Liu
Summary: SLC39A5 is upregulated in lung adenocarcinoma (LUAD), correlated with poor patient survival, promotes LUAD cell proliferation by activating the PI3K/AKT signaling pathway, and may serve as a novel prognostic biomarker and therapeutic target for LUAD.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Tianyu Zhai, Xiaoyu Zhang, Zhenyu Hei, Longyang Jin, Chao Han, Audrey Tsznam Ko, Xiaofeng Yu, Jiandong Wang
Summary: Isorhamnetin was found to suppress cell proliferation and metastasis, trigger apoptosis, and arrest the G2/M phase in gallbladder cancer cells through inactivation of the PI3K/AKT signaling cascade, providing a novel treatment approach for GBC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nuray Uremis, Muhammed Mehdi Uremis, Yilmaz Cigremis, Emir Tosun, Ahmet Baysar, Yusuf Turkoz
Summary: This study investigated the anticancer effect and underlying mechanism of cucurbitacin I (CuI) in hepatocellular carcinoma cells. The results showed that CuI significantly inhibited cell growth, induced antiproliferation, and disrupted the G2/M phase of the cell cycle in HepG2 cells. CuI also downregulated the expression of proteins and genes involved in the JAK/STAT3, MAPK/ERK, and AKT/mTOR signaling pathways, leading to apoptosis. These findings suggest that CuI has potential as a chemotherapeutic agent for hepatocellular carcinoma.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Safaa M. Kishk, Enas E. Eltamany, Mohamed S. Nafie, Roaa M. Khinkar, Rawan H. Hareeri, Sameh S. Elhady, Asmaa S. A. Yassen
Summary: A series of coumarin derivatives were synthesized and evaluated for their cytotoxicity. Compound (4) showed significant cytotoxicity against HL60 cells, while compound (8b) exhibited noticeable activity against HepG2 cells. The cytotoxicity of compounds (4) and (8b) was mediated through PI3K/AKT pathway inhibition.
Article
Biochemistry & Molecular Biology
Yu Cai, Peiyong Chen, Hui Xu, Shanglai Li, Bingru Zhao, Yixuan Fan, Feng Wang, Yanli Zhang
Summary: In this study, it was found that EZH2 gene knockdown in sheep pituitary cells led to decreased cell proliferation, increased apoptosis, and reduced FSH secretion. These effects were mediated through the modulation of the AKT/ERK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Kelei Li, Xianfeng Shao, Huiying Li, Xiaotong Kuang, Xiaolei Song, Yan Wang, Suqin Zhu, Duo Li
Summary: This study found that a combination of folic acid and n-3 polyunsaturated fatty acids has a better preventive effect on neural tube defects induced by maternal diabetes compared to folic acid alone. The combination treatment reduced neuroepithelial cell apoptosis and regulated the expression of key genes involved in diabetes-induced defects. The combination therapy also attenuated diabetes-induced hypermethylation and overexpression of genes related to one-carbon metabolism and lowered levels of homocysteine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Xiaotong Kuang, Kelei Li, Yan Shi, Xianfeng Shao, Huiying Li, Duo Li
Summary: The effects of dietary fiber on obesity-related traits have shown inconsistent results in previous studies. This study aimed to investigate whether genetic variants related to satiety and appetite can modify the impact of dietary fiber on obesity-related traits. The findings revealed that defatted flaxseed flour biscuits significantly reduced body weight and BMI in A-allele carriers of the FTO gene, but not in non-carriers. The biscuits also had a greater impact on fasting serum glucose reduction in participants with the CC genotype of the NPY gene compared to those with the TC and TT genotypes. Additionally, the presence of the T allele of the PCSK1 gene and the A allele of the BDNF gene increased the effectiveness of defatted flaxseed flour in reducing body weight and BMI. These results suggest that genetic variants related to satiety and appetite can modulate the effects of dietary fiber on obesity-related traits.
Article
Biochemistry & Molecular Biology
Kelei Li, Huiying Li, Xiaolei Song, Xiaotong Kuang, Shiyi Liu, Suqing Zhu, Duo Li
Summary: The present study investigated the preventive effect of mussel oil (MO) on gestational diabetes mellitus (GDM) in mice fed a high-fat and high-sucrose (HFHS) diet. Results showed that the MO group had lower AUC for OGTT and ITT compared with the control group. In addition, the MO group exhibited lower insulin resistance and fasting serum insulin levels, as well as higher levels of SphK2, Akt, and P-Akt in the liver. Overall, mussel oil showed better effects in improving glucose intolerance and insulin resistance during pregnancy compared to fish oil.
Review
Nutrition & Dietetics
Andrew J. Sinclair, Yonghua Wang, Duo Li
Summary: DHA is crucial for neural and visual function, but there is limited evidence to support the claim that low DHA levels are associated with child development disorders and neurological conditions.
Article
Food Science & Technology
Zhiyuan Liu, Jihong Yuan, Ping Wen, Xiaofei Guo, Kelei Li, Yinpeng Wang, Ruirui Liu, Yanjun Guo, Duo Li
Summary: This study aimed to assess the effects of blend oil on liver function markers in healthy subjects. The results showed that blend oil was more effective in reducing liver function markers such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) compared with soybean oil or lard alone. This suggests that blend oil may be beneficial for preventing non-alcoholic fatty liver disease in the healthy population.
Article
Biochemistry & Molecular Biology
Zhiyuan Liu, Jihong Yuan, Ping Wen, Xiaofei Guo, Haichao Wen, Yanjun Guo, Duo Li
Summary: The study found that blend oil (lard plus soybean oil) is more beneficial for body weight and liver function compared to the individual use of lard and soybean oil. It also reduces cardiometabolic risk factors in healthy subjects.
Article
Biochemistry & Molecular Biology
Andong Ji, Wei Chen, Chang Liu, Tianyu Zhang, Runjia Shi, Xinqi Wang, Huina Xu, Duo Li
Summary: The aim of this study was to investigate the preventive effect of soy protein and whey protein on high-fat diet-induced insulin resistance and its potential molecular mechanisms. The results showed that compared with the whey protein group, the soy protein group had significantly lower insulin concentration, insulin resistance, and liver weight. Furthermore, the expression levels of lipid metabolism-related genes in the liver, as well as the expression levels of glucose transport proteins and insulin receptor signaling pathway proteins in the liver and muscle, were significantly altered in the soy protein group. Additionally, the composition of gut microbiota was also changed in the soy protein group.
Article
Biochemistry & Molecular Biology
Xiangyuan Meng, Chunyan Tian, Chenqi Xie, Hao Zhang, Haoyu Wang, Mai Zhang, Zhenquan Lu, Duo Li, Lei Chen, Tianlin Gao
Summary: Obesity can greatly impair skeletal muscle function, but punicalagin (PUN) can prevent obesity-induced skeletal muscle dysfunction by regulating TET2. PUN supplementation increases muscle weight, grip strength, and muscle fiber count in obese mice. Additionally, PUN enhances the stability of TET2 protein and increases its demethylation activity.
Review
Biochemistry & Molecular Biology
Yi Ren, Fuhuai Jia, Duo Li
Summary: Instant powder foods are widely used in various food sectors and have the potential to provide health benefits with functional or beneficial compounds. The design of instant powder foods can be challenging due to their complex structures and flexible formulations. This review proposes a new classification method based on ingredient solubility and reconstituted product structure. The structure of instant powder foods is significantly influenced by their ingredients.
Article
Biochemistry & Molecular Biology
Andong Ji, Wei Chen, Tianyu Zhang, Runjia Shi, Xinqi Wang, Yan Wang, Huina Xu, Duo Li
Summary: The study found that whey protein was more effective than soy protein in preventing obesity, possibly by suppressing lipogenesis, activating brown adipose tissue, and promoting browning of inguinal white adipose tissue. In addition, lowering the protein-to-carbohydrate ratio was beneficial for combating obesity.
Article
Biochemistry & Molecular Biology
Shan Li, Mengli Li, Ronghua Guo, Ting Zhao, Xiang Gao, Kelei Li, Xiaofei Guo, Junhui Li, Duo Li
Summary: The study found that fucoidans extracted from sea cucumber Pearsonothuria graeffei (fuc-Pg) can prevent obesity and systemic inflammation through multiple mechanisms. Adding fuc-Pg significantly reduces weight gain and fat accumulation caused by a high-fat diet, improves serum lipid profile, reverses intestinal and white adipose tissue abnormalities induced by a high-fat diet, and reduces systemic inflammation.
Article
Biochemistry & Molecular Biology
Ze-Kai Fan, Wen-Jun Ma, Wei Zhang, Hui Li, Jie Zhai, Ting Zhao, Xiao-Fei Guo, Andrew J. Sinclair, Duo Li
Summary: This study investigated the relationship between changes in serum lipid metabolites and risk factors of NAFLD after fish oil or fish oil plus vitamin D intervention. The results showed that serum levels of phosphatidylcholine (PC) (16:1/22:6) were increased after interventions. These levels were correlated with liver function, lipid metabolism, and inflammation markers in NAFLD subjects.
Article
Biochemistry & Molecular Biology
Zekai Fan, Chong Wang, Ting Yang, Tianlin Gao, Dan Wang, Xiaoyan Zhao, Xiaofei Guo, Duo Li
Summary: Coffee peel extracts containing caffeine and seven monomers of flavonoids can protect against NAFLD by regulating the FGF21-adiponectin signaling pathway.
Article
Biochemistry & Molecular Biology
Huijun Zhang, Xiang Gao, Kelei Li, Yandi Liu, Dhanushka S. Hettiarachichi, Bruce Sunderland, Duo Li
Summary: Our study found that sandalwood seed oil has an ameliorative effect on insulin resistance induced by a high-fat/high-sucrose diet in rats by regulating hepatic inflammation related blockage of the insulin signaling pathway.
Article
Biochemistry & Molecular Biology
Xiaomeng Lu, Qi Ce, Long Jin, Jie Zheng, Mei Sun, Xue Tang, Duo Li, Jin Sun
Summary: Deoiled sunflower seeds (SFS) were found to alleviate depression-like symptoms induced by chronic unpredictable mild stress (CUMS) in mice, possibly through increasing levels of aromatic amino acids and neurotransmitters, ameliorating oxidative stress and inflammation, and regulating abnormal metabolite levels to normal levels.