A proteomics view on integrin-mediated adhesions

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

(2016) Adam Byron et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome

(2016) Edward R. Horton et al.   EXPERIMENTAL CELL RESEARCH

Kindlin-2 directly binds actin and regulates integrin outside-in signaling

(2016) Kamila Bledzka et al.   JOURNAL OF CELL BIOLOGY

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition

(2016) Edward R. Horton et al.   JOURNAL OF CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Epithelial polarity – Generating and integrating signals from the ECM with integrins

(2015) Aki Manninen   EXPERIMENTAL CELL RESEARCH

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Proteomic analysis of integrin-associated complexes from mesenchymal stem cells

(2015) Jila N. Ajeian et al.   Proteomics Clinical Applications

Emerging properties of adhesion complexes: what are they and what do they do?

(2015) Jonathan D. Humphries et al.   TRENDS IN CELL BIOLOGY

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

(2015) Joseph Robertson et al.   Nature Communications

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

(2015) Adam Byron et al.   Nature Communications

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

(2015) Elena Rainero et al.   Cell Reports

Microtubules Regulate Focal Adhesion Dynamics through MAP4K4

(2014) Jiping Yue et al.   DEVELOPMENTAL CELL

GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

(2014) I.-H. Huang et al.   JOURNAL OF CELL SCIENCE

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-Dependent Modulation of Adhesion Complex Composition

(2014) Daniel H. J. Ng et al.   PLoS One

Spatial proteomic and phospho-proteomic organization in three prototypical cell migration modes

(2014) Georgios Fengos et al.   Proteome Science

MS/MS-based strategies for proteomic profiling of invasive cell structures

(2014) Serhiy Havrylov et al.   PROTEOMICS

Mechanosensitivity and compositional dynamics of cell–matrix adhesions

(2013) Herbert B Schiller et al.   EMBO REPORTS

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

(2013) Markku Varjosalo et al.   NATURE METHODS

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells

(2013) Terhi P. Teräväinen et al.   PLoS One

Myosin II-Mediated Focal Adhesion Maturation Is Tension Insensitive

(2013) Jonathan Stricker et al.   PLoS One

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

Opening the floodgates: proteomics and the integrin adhesome

(2012) Tamar Geiger et al.   CURRENT OPINION IN CELL BIOLOGY

Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres

(2012) Pasquale Cervero et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

FAK and talin: Who is taking whom to the integrin engagement party?: Figure 1.

(2012) Bryan Serrels et al.   JOURNAL OF CELL BIOLOGY

Targeting and transport: How microtubules control focal adhesion dynamics

(2012) Samantha Stehbens et al.   JOURNAL OF CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions

(2012) Christopher D. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

An integrin–ILK–microtubule network orients cell polarity and lumen formation in glandular epithelium

(2012) Nasreen Akhtar et al.   NATURE CELL BIOLOGY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

The interactome of LIM domain proteins: The contributions of LIM domain proteins to heart failure and heart development

(2012) Amy Li et al.   PROTEOMICS

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

(2012) Adam Byron et al.   PROTEOMICS

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

The C terminus of talin links integrins to cell cycle progression

(2011) Pengbo Wang et al.   JOURNAL OF CELL BIOLOGY

Laminin 511 partners with laminin 332 to mediate directional migration of Madin–Darby canine kidney epithelial cells

(2011) Patricia G. Greciano et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

(2011) A. J. Ehrlicher et al.   NATURE

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two Distinct Integrin-Mediated Mechanisms Contribute to Apical Lumen Formation in Epithelial Cells

(2011) Satu Marja Myllymäki et al.   PLoS One

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Regulation of membrane traffic by integrin signaling

(2011) Sara A. Wickström et al.   TRENDS IN CELL BIOLOGY

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Determination of Protein Stoichiometry within Protein Complexes Using Absolute Quantification and Multiple Reaction Monitoring

(2010) Carla Schmidt et al.   ANALYTICAL CHEMISTRY

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Integrins during evolution: Evolutionary trees and model organisms

(2009) Mark S. Johnson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Combined Integrin Phosphoproteomic Analyses and Small Interfering RNA-Based Functional Screening Identify Key Regulators for Cancer Cell Adhesion and Migration

(2009) Y. Chen et al.   CANCER RESEARCH

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

(2009) Timo Glatter et al.   Molecular Systems Biology

Quantitative interaction proteomics using mass spectrometry

(2009) Alexander Wepf et al.   NATURE METHODS

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Cell Signaling in Space and Time: Where Proteins Come Together and When They're Apart

(2009) J. D. Scott et al.   SCIENCE

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner

(2008) H. Hirata et al.   JOURNAL OF CELL SCIENCE

Mapping the Integrin-Linked Kinase Interactome Using SILAC

(2008) Iveta Dobreva et al.   JOURNAL OF PROTEOME RESEARCH

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow

(2008) Antonina Y. Alexandrova et al.   PLoS One