Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition

The many faces of cell adhesion during Drosophila muscle development

(2015) Aidan P. Maartens et al.   DEVELOPMENTAL BIOLOGY

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Proteomic analysis of integrin-associated complexes from mesenchymal stem cells

(2015) Jila N. Ajeian et al.   Proteomics Clinical Applications

Emerging properties of adhesion complexes: what are they and what do they do?

(2015) Jonathan D. Humphries et al.   TRENDS IN CELL BIOLOGY

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

(2015) Joseph Robertson et al.   Nature Communications

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

(2015) Adam Byron et al.   Nature Communications

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions

(2014) Alexia I. Bachir et al.   CURRENT BIOLOGY

Microtubules Regulate Focal Adhesion Dynamics through MAP4K4

(2014) Jiping Yue et al.   DEVELOPMENTAL CELL

FAK dimerization controls its kinase-dependent functions at focal adhesions

(2014) K. Brami-Cherrier et al.   EMBO JOURNAL

GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

(2014) I.-H. Huang et al.   JOURNAL OF CELL SCIENCE

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The InterPro protein families database: the classification resource after 15 years

(2014) Alex Mitchell et al.   NUCLEIC ACIDS RESEARCH

The Inhibition of Src Family Kinase Suppresses Pancreatic Cancer Cell Proliferation, Migration, and Invasion

(2014) Dong Wook Je et al.   PANCREAS

Microtubule-Dependent Modulation of Adhesion Complex Composition

(2014) Daniel H. J. Ng et al.   PLoS One

Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol

(2014) Jan-Erik Hoffmann et al.   eLife

Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics

(2013) M. Luo et al.   CANCER RESEARCH

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells

(2012) María Pilar Sánchez-Bailón et al.   CELLULAR SIGNALLING

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Integrin bi-directional signaling across the plasma membrane

(2012) Ping Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

(2012) Adam Byron et al.   PROTEOMICS

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

(2011) Alan Serrels et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

(2010) Isabelle Tanjoni et al.   CANCER BIOLOGY & THERAPY

Adhesion signalling complexes

(2010) Adam Byron et al.   CURRENT BIOLOGY

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)

(2010) Keefe T. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

MatrixDB, a database focused on extracellular protein–protein and protein–carbohydrate interactions

(2009) Emilie Chautard et al.   BIOINFORMATICS

Focal adhesion kinase-dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions

(2009) David W. Dumbauld et al.   BIOLOGY OF THE CELL

Combined Integrin Phosphoproteomic Analyses and Small Interfering RNA-Based Functional Screening Identify Key Regulators for Cancer Cell Adhesion and Migration

(2009) Y. Chen et al.   CANCER RESEARCH

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

Src and focal adhesion kinase as therapeutic targets in cancer

(2008) Valerie G Brunton et al.   CURRENT OPINION IN PHARMACOLOGY

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Integrated network analysis platform for protein-protein interactions

(2008) Jianmin Wu et al.   NATURE METHODS