Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

Autophagy activation by NFκB is essential for cell survival after heat shock

(2014) Mathieu Nivon et al.   Autophagy

CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF- B Activation and Up-Regulation of c-FLIP and Bcl-xL

(2014) M. Travert et al.   JOURNAL OF IMMUNOLOGY

NF-κB function in B lymphocytes

(2012) Mary Kaileh et al.   IMMUNOLOGICAL REVIEWS

IKK biology

(2012) Fei Liu et al.   IMMUNOLOGICAL REVIEWS

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

(2012) Kian-Huat Lim et al.   IMMUNOLOGICAL REVIEWS

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

NF-κB subunit specificity in hemopoiesis

(2012) Steve Gerondakis et al.   IMMUNOLOGICAL REVIEWS

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Protein kinase Cη activates NF-κB in response to camptothecin-induced DNA damage

(2011) Hadas Raveh-Amit et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Importance of PIKKs in NF-κB activation by genotoxic stress

(2011) Hélène Sabatel et al.   BIOCHEMICAL PHARMACOLOGY

p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF- B

(2011) R. F. Johnson et al.   CANCER RESEARCH

Akt-Dependent Glucose Metabolism Promotes Mcl-1 Synthesis to Maintain Cell Survival and Resistance to Bcl-2 Inhibition

(2011) J. L. Coloff et al.   CANCER RESEARCH

 Np63 Versatilely Regulates a Broad NF- B Gene Program and Promotes Squamous Epithelial Proliferation, Migration, and Inflammation

(2011) X. Yang et al.   CANCER RESEARCH

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

p53-mediated induction of Noxa and p53AIP1 requires NFκB

(2011) Jim O’Prey et al.   CELL CYCLE

Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis

(2011) G Shu et al.   CELL DEATH AND DIFFERENTIATION

F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway

(2011) R Ge et al.   CELL DEATH AND DIFFERENTIATION

Multiple Facets of NF-κB in the Heart

(2011) Joseph W. Gordon et al.   CIRCULATION RESEARCH

TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8

(2011) Aminah Ikner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Factor-κB (NF-κB) Mediates a Protective Response in Cancer Cells Treated with Inhibitors of Fatty Acid Synthase

(2011) Colleen R. M. Lemmon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of IκB Kinase (IKK)-mediated RelA Serine 536 Phosphorylation Sensitizes Human Multiple Myeloma Cells to Histone Deacetylase (HDAC) Inhibitors

(2011) Yun Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal IκBα Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-α-induced Nuclear Factor-κB (NF-κB) Activity

(2011) Amy Colleran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

(2011) Wei Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL)

(2011) Prashant Bavi et al.   JOURNAL OF PATHOLOGY

NF- B Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis

(2011) R. J. Thapa et al.   MOLECULAR AND CELLULAR BIOLOGY

Heat shock protein 90–mediated inactivation of nuclear factor-κB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells

(2011) Qian Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in Ras-Induced Malignant Transformation: Fatal or Vital?

(2011) Guillermo Mariño et al.   MOLECULAR CELL

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

(2011) Yi-Hung Ou et al.   MOLECULAR CELL

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR

(2011) Trever G. Bivona et al.   NATURE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB

(2011) Sudarshana Purkayastha et al.   NATURE MEDICINE

ChIP-on-Chip Analysis of In Vivo Mutant p53 Binding To Selected Gene Promoters

(2011) Stefania Dell'Orso et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

NF-κB suppresses ROS levels in BCR–ABL+ cells to prevent activation of JNK and cell death

(2011) S J Stein et al.   ONCOGENE

NF-κB Potentiates Caspase Independent Hydrogen Peroxide Induced Cell Death

(2011) Jessica Q. Ho et al.   PLoS One

I B kinase   and TANK-binding kinase 1 activate AKT by direct phosphorylation

(2011) X. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Response and Resistance to NF- B Inhibitors in Mouse Models of Lung Adenocarcinoma

(2011) W. Xue et al.   Cancer Discovery

Signalling to drug resistance in CLL

(2010) Erin Hertlein et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

I B kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia

(2010) N. Chapuis et al.   BLOOD

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Nuclear Factor-κB modulates cellular glutathione and prevents oxidative stress in cancer cells

(2010) Qinghang Meng et al.   CANCER LETTERS

Requirement of the NF-κB Subunit p65/RelA for K-Ras–Induced Lung Tumorigenesis

(2010) Daniela S. Bassères et al.   CANCER RESEARCH

Regulation of p53 Family Member Isoform  Np63  by the Nuclear Factor- B Targeting Kinase I B Kinase  

(2010) A. Chatterjee et al.   CANCER RESEARCH

Anti-apoptotic effect of hyperglycemia can allow survival of potentially autoreactive T cells

(2010) P Ramakrishnan et al.   CELL DEATH AND DIFFERENTIATION

Regulation of NF-κB signaling by caspases and MALT1 paracaspase

(2010) Jens Staal et al.   CELL RESEARCH

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

(2010) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Oncoprotein SF2/ASF Promotes Non-Small Cell Lung Cancer Survival by Enhancing Survivin Expression

(2010) T. Ezponda et al.   CLINICAL CANCER RESEARCH

To fight or die—inhibitor of apoptosis proteins at the crossroad of innate immunity and death

(2010) Juanita Lopez et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of NF-κB induces a switch from CD95L-dependent to CD95L-independent and JNK-mediated apoptosis in T cells

(2010) Michael K. Kießling et al.   FEBS LETTERS

Understanding rituximab function and resistance: implications for tailored therapy

(2010) Alfredo Amoroso   Frontiers in Bioscience-Landmark

Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function

(2010) Aymone Gurtner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB

(2010) Hongyu Guan et al.   JOURNAL OF PATHOLOGY

SUMOylation-Dependent Localization of IKKɛ in PML Nuclear Bodies Is Essential for Protection against DNA-Damage-Triggered Cell Death

(2010) Florian Renner et al.   MOLECULAR CELL

RETRACTED: The Skp2 Promoter Integrates Signaling through the NF-κB, p53, and Akt/GSK3β Pathways to Regulate Autophagy and Apoptosis

(2010) Benjamin Barré et al.   MOLECULAR CELL

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

(2010) Zhao-Hui Wu et al.   MOLECULAR CELL

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

IKK antagonizes activation-induced cell death of CD4+ T cells in aged mice via inhibition of JNK activation

(2010) Hongbin Deng et al.   MOLECULAR IMMUNOLOGY

IKK-dependent, NF-κB-independent control of autophagic gene expression

(2010) W C Comb et al.   ONCOGENE

Cross talk between stimulated NF-κB and the tumor suppressor p53

(2010) G Schneider et al.   ONCOGENE

Emerging roles for the non-canonical IKKs in cancer

(2010) R R Shen et al.   ONCOGENE

NF- B inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2

(2010) V. Busuttil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic Activation of NF- B

(2010) L. M. Staudt   Cold Spring Harbor Perspectives in Biology

Deregulation of IKBKE Is Associated with Tumor Progression, Poor Prognosis, and Cisplatin Resistance in Ovarian Cancer

(2009) Jian-Ping Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Is There a Role for Nuclear Factor κB in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?

(2009) Amandine Plantivaux et al.   Annals of the New York Academy of Sciences

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

A critical role of TAK1 in B-cell receptor–mediated nuclear factor κB activation

(2009) James Schuman et al.   BLOOD

The Receptor Interacting Protein 1 Inhibits p53 Induction through NF- B Activation and Confers a Worse Prognosis in Glioblastoma

(2009) S. Park et al.   CANCER RESEARCH

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis

(2009) P Wang et al.   CELL DEATH AND DIFFERENTIATION

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma

(2009) Lia E. Perez et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

IKKϵ Phosphorylation of Estrogen Receptor α Ser-167 and Contribution to Tamoxifen Resistance in Breast Cancer

(2009) Jian-Ping Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2-Dependent Inhibition of p53 Is Required for Epstein-Barr Virus B-Cell Growth Transformation and Infected-Cell Survival

(2009) E. Forte et al.   JOURNAL OF VIROLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

(2009) Etienne Meylan et al.   NATURE

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

(2009) Sung-Gyoo Park et al.   NATURE IMMUNOLOGY

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

Addressing Reported Pro-Apoptotic Functions of NF-κB: Targeted Inhibition of Canonical NF-κB Enhances the Apoptotic Effects of Doxorubicin

(2009) Brian K. Bednarski et al.   PLoS One

Loss of p53 enhances catalytic activity of IKK  through O-linked  -N-acetyl glucosamine modification

(2009) K. Kawauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP

(2009) Yifeng Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NF-κB-independent functions of IKK subunits in immunity and cancer

(2009) Alain Chariot   TRENDS IN CELL BIOLOGY

Activated p53 induces NF-κB DNA binding but suppresses its transcriptional activation

(2008) Keiko Kawauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The NF- B subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target

(2008) S. Hewamana et al.   BLOOD

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

(2008) N Ueffing et al.   CELL DEATH AND DIFFERENTIATION

Concepts of activated T cell death

(2008) Dirk Brenner et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined Inhibition of MAPK and mTOR Signaling Inhibits Growth, Induces Cell Death, and Abrogates Invasive Growth of Melanoma Cells

(2008) Konstantinos G. Lasithiotakis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis

(2008) Sharmila Shankar et al.   Molecular Cancer

I B kinase   inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells

(2008) E. A. Duncan et al.   MOLECULAR CANCER THERAPEUTICS

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

Cancers take their Toll—the function and regulation of Toll-like receptors in cancer cells

(2008) R Chen et al.   ONCOGENE

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

NF B activation is associated with its O-GlcNAcylation state under hyperglycemic conditions

(2008) W. H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonism of E2F-1 regulated Bnip3 transcription by NF- B is essential for basal cell survival

(2008) J. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA