Lymphotoxin, NF-?B, and Cancer: The Dark Side of Cytokines

Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-κB Pathway in Adult T Cell Leukemia and Other Cancers

(2012) Makoto Yamagishi et al.   CANCER CELL

Human papillomavirus 16E6 suppresses major histocompatibility complex class I by upregulating lymphotoxin expression in human cervical cancer cells

(2011) Dong-Hern Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs

(2011) A. Rehm et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Lymphotoxin Controls the IL-22 Protection Pathway in Gut Innate Lymphoid Cells during Mucosal Pathogen Challenge

(2011) Alexei V. Tumanov et al.   Cell Host & Microbe

Biology and signal transduction pathways of the Lymphotoxin-αβ/LTβR system

(2011) Caroline Remouchamps et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling

(2011) Mingzhao Zhu et al.   IMMUNOLOGICAL REVIEWS

Induction of the Alternative NF- B Pathway by Lymphotoxin    (LT  ) Relies on Internalization of LT  Receptor

(2011) C. Ganeff et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

(2011) Wei Tan et al.   NATURE

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

(2010) Hiroyuki Takahashi et al.   CANCER CELL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis

(2010) Judy Young et al.   CYTOKINE

Lymphotoxin Beta Receptor Signaling in Intestinal Epithelial Cells Orchestrates Innate Immune Responses against Mucosal Bacterial Infection

(2010) Yugang Wang et al.   IMMUNITY

Lymphotoxin-β receptor activation by lymphotoxin-α1β2 and LIGHT promotes tumor growth in an NFκB-dependent manner

(2010) Barbara Daller et al.   INTERNATIONAL JOURNAL OF CANCER

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?

(2010) Y. K. Lee et al.   SCIENCE

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP

(2009) Yee Soo Chae et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

(2009) Julia Bollrath et al.   EMBO REPORTS

Neutralization of LIGHT ameliorates acute dextran sodium sulphate-induced intestinal inflammation

(2009) Michaela Jungbeck et al.   IMMUNOLOGY

The CD4+ T Cell-Mediated IFN-  Response to Helicobacter Infection Is Essential for Clearance and Determines Gastric Cancer Risk

(2009) A. Sayi et al.   JOURNAL OF IMMUNOLOGY

Identification of a novel 12p13.3 amplicon in nasopharyngeal carcinoma

(2009) Yvonne Y-Y Or et al.   JOURNAL OF PATHOLOGY

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

(2009) Eugene Y Chiang et al.   NATURE MEDICINE

Prostaglandins and sickness behavior: Old story, new insights

(2009) Emilie Pecchi et al.   PHYSIOLOGY & BEHAVIOR

Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition

(2009) P. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases

(2008) Kako Takei et al.   BMC CANCER

Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice

(2008) Dmitry V. Kuprash et al.   CANCER LETTERS

T Cell-Derived Lymphotoxin Regulates Liver Regeneration

(2008) Alexei V. Tumanov et al.   GASTROENTEROLOGY

Lymphotoxin-β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury

(2008) Richard G. Ruddell et al.   HEPATOLOGY

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation—Opposite functions for surface lymphotoxin expressed by T and B lymphocytes

(2007) Michaela Jungbeck et al.   MOLECULAR IMMUNOLOGY