p120 catenin is a key effector of a Ras-PKCɛ oncogenic signaling axis

Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities

(2012) D. W. Craig et al.   MOLECULAR CANCER THERAPEUTICS

Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma

(2011) B. B. Hafeez et al.   CANCER RESEARCH

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions

(2011) Fernando Benavides et al.   CELL CYCLE

EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

(2011) Michela Garofalo et al.   NATURE MEDICINE

C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCθ inhibitors: Part II

(2009) Amar S. Prashad et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase C 

(2009) P. Gandellini et al.   CANCER RESEARCH

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

(2009) B. T. Hennessy et al.   CANCER RESEARCH

An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth

(2009) Michael R. Dohn et al.   JOURNAL OF CELL BIOLOGY

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein kinase Cε: an oncogene and emerging tumor biomarker

(2009) Michael A Gorin et al.   Molecular Cancer

RSK Is a Principal Effector of the RAS-ERK Pathway for Eliciting a Coordinate Promotile/Invasive Gene Program and Phenotype in Epithelial Cells

(2009) Ulrik Doehn et al.   MOLECULAR CELL

Inhibitor hijacking of Akt activation

(2009) Tatsuya Okuzumi et al.   Nature Chemical Biology

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity

(2009) Angus J M Cameron et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PKC  Regulation of an  5 Integrin-ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells

(2009) S. Tuomi et al.   Science Signaling

PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCα-dependent pathway

(2008) Meredith V. Brown et al.   EXPERIMENTAL CELL RESEARCH

p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression

(2008) Edwin Soto et al.   JOURNAL OF CELL BIOLOGY

Loss of protein kinase C  results in impaired cutaneous wound closure and myofibroblast function

(2008) A. Leask et al.   JOURNAL OF CELL SCIENCE

Breast carcinomas that co-express E- and P-cadherin are associated with p120-catenin cytoplasmic localisation and poor patient survival

(2008) J Paredes et al.   JOURNAL OF CLINICAL PATHOLOGY

The regulated assembly of a PKCɛ complex controls the completion of cytokinesis

(2008) Adrian T. Saurin et al.   NATURE CELL BIOLOGY