Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets

The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

(2013) Eugenia Cifuentes-Pagano et al.   ANTIOXIDANTS & REDOX SIGNALING

Nox Family NADPH Oxidases in Mechano-Transduction: Mechanisms and Consequences

(2013) Ralf P. Brandes et al.   ANTIOXIDANTS & REDOX SIGNALING

A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular Cells

(2013) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Overcoming disease-induced growth factor resistance in therapeutic angiogenesis using recombinant co-receptors delivered by a liposomal system

(2013) Subhamoy Das et al.   BIOMATERIALS

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties

(2013) Françoise Bono et al.   CANCER CELL

Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization

(2013) Haibo Wang et al.   FASEB JOURNAL

Control of angiogenesis dictated by picomolar superoxide levels

(2013) Shyamal C. Bir et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of NADPH Oxidase by Apocynin Attenuates Progression of Atherosclerosis

(2013) Kara Kinkade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The involvement of Helicobacter pylori thioredoxin-1 in gastric carcinogenesis

(2013) Y. Shi et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Nox1 Oxidase Suppresses Influenza A Virus-Induced Lung Inflammation and Oxidative Stress

(2013) Stavros Selemidis et al.   PLoS One

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

(2013) Mads Daugaard et al.   Nature Communications

The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation

(2012) David E. Green et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Glutathione Peroxidase-1 Reduces Influenza A Virus–Induced Lung Inflammation

(2012) Selcuk Yatmaz et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

NADPH Oxidases as Regulators of Tumor Angiogenesis: Current and Emerging Concepts

(2012) Sanja Coso et al.   ANTIOXIDANTS & REDOX SIGNALING

Divergent Effects of p47 phox Phosphorylation at S303-4 or S379 on Tumor Necrosis Factor-α Signaling via TRAF4 and MAPK in Endothelial Cells

(2012) Lei Teng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Opportunity Nox: The Future of NADPH Oxidases as Therapeutic Targets in Cardiovascular Disease

(2012) Jennifer Streeter et al.   Cardiovascular Therapeutics

VAS2870 is a pan-NADPH oxidase inhibitor

(2012) Kirstin Wingler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NADPH oxidases as therapeutic targets in ischemic stroke

(2012) Timo Kahles et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

(2012) Sebastian Altenhöfer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ebselen and Congeners Inhibit NADPH Oxidase 2-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits

(2012) Susan M.E. Smith et al.   CHEMISTRY & BIOLOGY

Methods to monitor classical protein-tyrosine phosphatase oxidation

(2012) Robert Karisch et al.   FEBS Journal

TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers

(2012) Benjamin J. Shields et al.   MOLECULAR AND CELLULAR BIOLOGY

NOX2β: A Novel Splice Variant of NOX2 That Regulates NADPH Oxidase Activity in Macrophages

(2012) Craig B. Harrison et al.   PLoS One

NADPH Oxidase 4 Mediates Insulin-Stimulated HIF-1α and VEGF Expression, and Angiogenesis In Vitro

(2012) Dan Meng et al.   PLoS One

Targeting NADPH oxidases in vascular pharmacology

(2012) Agata Schramm et al.   VASCULAR PHARMACOLOGY

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells

(2011) Patricia Sancho et al.   BIOCHEMICAL PHARMACOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Insulin-Like Growth Factor Binding Protein-Related Protein 1 Mediates VEGF-Induced Proliferation, Migration and Tube Formation of Retinal Endothelial Cells

(2011) Tao Sun et al.   CURRENT EYE RESEARCH

Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2

(2011) Gábor Csányi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial reactive oxygen species promote p65 nuclear translocation mediating high-phosphate-induced vascular calcification in vitro and in vivo

(2011) Ming-Ming Zhao et al.   KIDNEY INTERNATIONAL

In search of new therapeutic targets and strategies for heart failure: recent advances in basic science

(2011) Ajay M Shah et al.   LANCET

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells

(2011) W.-C. Huang et al.   MOLECULAR CANCER RESEARCH

Right-side and left-side colon cancer follow different pathways to relapse

(2011) Kerry M. Bauer et al.   MOLECULAR CARCINOGENESIS

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells

(2011) Olga Efimova et al.   PLoS One

Correction: Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism

(2011) Sarah Garrido-Urbani et al.   PLoS One

Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells

(2011) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy

(2011) Ross Vlahos et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder

(2011) Keiji Shimada et al.   BMC Urology

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

A Novel and Specific NADPH Oxidase-1 (Nox1) Small-Molecule Inhibitor Blocks the Formation of Functional Invadopodia in Human Colon Cancer Cells

(2010) Davide Gianni et al.   ACS Chemical Biology

Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma

(2010) Muzaffer Sanci et al.   ACTA HISTOCHEMICA

The NADPH Oxidase Subunit p22phox Inhibits the Function of the Tumor Suppressor Protein Tuberin

(2010) Karen Block et al.   AMERICAN JOURNAL OF PATHOLOGY

NADPH Oxidase 2 Mediates Intermittent Hypoxia-Induced Mitochondrial Complex I Inhibition: Relevance to Blood Pressure Changes in Rats

(2010) Shakil A. Khan et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects

(2010) John J. Tanner et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel antiangiogenic agents in dermatology

(2010) Ricardo L. Berrios et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Autophagy, reactive oxygen species and the fate of mammalian cells

(2010) Irena Szumiel   FREE RADICAL RESEARCH

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

PET imaging of tumor angiogenesis in mice with VEGF-A-targeted 86Y-CHX-A″-DTPA-bevacizumab

(2010) Tapan K. Nayak et al.   INTERNATIONAL JOURNAL OF CANCER

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Directed in vivo angiogenesis assay and the study of systemic neoangiogenesis in cancer

(2010) Claudio Napoli et al.   INTERNATIONAL JOURNAL OF CANCER

Pro-inflammatory angiogenesis is mediated by p38 MAP kinase

(2010) Gangaraju Rajashekhar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanisms Contributing to Cerebral Infarct Size after Stroke: Gender, Reperfusion, T Lymphocytes, and Nox2-Derived Superoxide

(2010) Vanessa H Brait et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Peroxynitrite-Dependent Killing of Cancer Cells and Presentation of Released Tumor Antigens by Activated Dendritic Cells

(2010) Jennifer Fraszczak et al.   JOURNAL OF IMMUNOLOGY

Human endothelial stem/progenitor cells, angiogenic factors and vascular repair

(2010) S. M. Watt et al.   Journal of the Royal Society Interface

Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony

(2010) Pasquale Laise et al.   JOURNAL OF THEORETICAL BIOLOGY

Antioxidants: Benefits and risks for long-term health

(2010) Daisaku Yoshihara et al.   MATURITAS

Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib

(2010) J C Welti et al.   ONCOGENE

Redox regulation of Nox proteins

(2010) Srikanth Pendyala et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Synergistic Angiogenic Effect of Codelivering Fibroblast Growth Factor 2 and Granulocyte-Colony Stimulating Factor from Fibrin Scaffolds and Bone Marrow Transplantation in Critical Limb Ischemia

(2010) Hans Layman et al.   TISSUE ENGINEERING PART A

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice

(2009) Courtney P. Judkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

(2009) K. Shimada et al.   CANCER RESEARCH

The global burden of cancer: priorities for prevention

(2009) M. J. Thun et al.   CARCINOGENESIS

Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues

(2009) Urbain Weyemi et al.   ENDOCRINE-RELATED CANCER

Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues

(2009) Agnes Juhasz et al.   FREE RADICAL RESEARCH

NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival

(2009) Hitesh Peshavariya et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

NADPH Oxidase-Dependent Signaling in Endothelial Cells: Role in Physiology and Pathophysiology

(2008) Randall S. Frey et al.   ANTIOXIDANTS & REDOX SIGNALING

Vascular Endothelial Growth Factor Mediated Decrease in Plasma Soluble Vascular Endothelial Growth Factor Receptor-2 Levels as a Surrogate Biomarker for Tumor Growth

(2008) J. M.L. Ebos et al.   CANCER RESEARCH

Oxidative Stress Is Inherent in Prostate Cancer Cells and Is Required for Aggressive Phenotype

(2008) B. Kumar et al.   CANCER RESEARCH

ISCHEMIC AND PEROXYNITRITE PRECONDITIONING EFFECTS IN CHRONIC HYPOXIC RAT LUNG

(2008) Nilüfer N. Turan et al.   EXPERIMENTAL LUNG RESEARCH

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE

NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition

(2008) Stavros Selemidis et al.   PHARMACOLOGY & THERAPEUTICS

Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase

(2008) Michela G. Schäppi et al.   Seminars in Immunopathology