Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease

Familial Alzheimer's Disease Mutations in Presenilins: Effects on Endoplasmic Reticulum Calcium Homeostasis and Correlation with Clinical Phenotypes

(2017) Omar Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

Upregulation of Presenilin 1 in Brains of Sporadic, Late-Onset Alzheimer's Disease

(2017) Roberta Borghi et al.   JOURNAL OF ALZHEIMERS DISEASE

Presenilin-1 Holoprotein is an Interacting Partner of Sarco Endoplasmic Reticulum Calcium-ATPase and Confers Resistance to Endoplasmic Reticulum Stress

(2017) Haifeng Jin et al.   JOURNAL OF ALZHEIMERS DISEASE

Presenilins: Role in calcium homeostasis

(2012) Kamran Honarnejad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

What the halted phase III γ-secretase inhibitor trial may (or may not) be telling us

(2011) Nina F. Schor   ANNALS OF NEUROLOGY

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo

(2011) Tong Li et al.   PLoS One

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer’s disease pathogenesis

(2011) Charlene Supnet et al.   Science China-Life Sciences

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease

(2010) Simonetta Camandola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The dysregulation of intracellular calcium in Alzheimer disease

(2010) Charlene Supnet et al.   CELL CALCIUM

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of  -Secretase-Mediated Intramembrane Proteolysis

(2010) A. Fukumori et al.   JOURNAL OF NEUROSCIENCE

Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics

(2010) Janet E. McCombs et al.   Molecular BioSystems

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

(2009) Lucia Brunello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Intracellular Calcium Deficits in Drosophila Cholinergic Neurons Expressing Wild Type or FAD-Mutant Presenilin

(2009) Kinga Michno et al.   PLoS One

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

(2008) Volodya Hayrapetyan et al.   CELL CALCIUM

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

(2007) Volodymyr Rybalchenko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY